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公开(公告)号：US20050167370A1
公开(公告)日：2005-08-04
申请号：US10814177
申请日：2004-04-01
申请人： Mitsutoshi Nakajima , Yuji Kikuchi , Taiji Nishi , Takenori Kitani , Yukihiro Yanagawa , Motohiro Fukuda
发明人： Mitsutoshi Nakajima , Yuji Kikuchi , Taiji Nishi , Takenori Kitani , Yukihiro Yanagawa , Motohiro Fukuda
IPC分类号： B81B1/00 , B01D29/00 , B01D29/46 , B01F3/08 , B01F5/04 , B01F13/00 , B01J13/00 , B01J19/00 , B01D37/00 , H01L21/302 , H01L21/461
CPC分类号： B01F13/0059 , B01D29/00 , B01F3/0807 , B01F5/0475 , B01F5/0483 , B01F2215/0431
摘要： The resin microchannel substrate has a surface where a recess leading to a fluid supply port and a bank adjacent to the recess and having many micro grooves on a surface are formed. The grooves form microchannels connecting the inside of the recess and the outside of the recess when the surface of the substrate is firmly attached to a flat plate serving as a cover. The width and height of the microchannel are within a range of 1 to 300 μm, and the width/height ratio of the channel is within a range of 1:20 to 20:1.
摘要翻译： 树脂微通道基板具有表面，其中形成有通向流体供给口的凹部和与凹部相邻的堤，并且在表面上具有许多微槽。 当基板的表面牢固地附接到用作盖的平板时，凹槽形成连接凹部的内部和凹部的外部的微通道。 微通道的宽度和高度在1至300μm的范围内，并且通道的宽/高比在1:20至20:1的范围内。
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2.发明申请Process for Producing Microsphere with Use of Metal Substrate having Through-Hole 有权使用具有通孔的金属基板生产微球的方法公开(公告)号：US20080061459A1
公开(公告)日：2008-03-13
申请号：US11577474
申请日：2005-10-11
CPC分类号： B01J13/04 , A23P10/25 , A61K9/1682 , B01F3/0807 , B01F5/0475 , B01F13/0059 , B01F2215/0014 , B01F2215/0016 , B01F2215/0019 , B01F2215/0031 , B01F2215/0034 , B01J13/02 , C25D1/08 , Y10T428/24273
摘要： An object of the present invention is to provide a process for producing microspheres that are solid microparticles or liquid microparticles for use as an emulsion employed in the food industry, production of medicine and cosmetic etc. or an emulsion for DDS (drug delivery system). The object is attained by a process for producing a microsphere including: separating a disperse phase from a continuous phase by a substrate 1 having a through-hole 7; and extruding the disperse phase into the continuous phase through the through-hole 7, in which the substrate having the through-hole 7 with a width of 0.5 to 500 μm, a depth of 10 μm to 6000 μm and a ratio of the width to the depth of the through-hole 7 of 1 to 1/30 is a metal substrate.
摘要翻译： 本发明的目的是提供一种制备用作食品工业中使用的乳液的固体微粒或液体微粒的微球的制造方法，药物和化妆品的制造等，或用于DDS（药物输送系统）的乳液。 该目的通过一种制备微球体的方法来实现，包括：通过具有通孔7的基底1将分散相与连续相分离; 并通过通孔7将分散相挤出到连续相中，其中具有宽度为0.5-500μm的通孔7的基底，深度为10μm至6000μm，宽度与 通孔7的深度为1〜1/30是金属基板。
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3.发明授权Process for producing microsphere with use of metal substrate having through-hole 有权使用具有通孔的金属基材制造微球的方法公开(公告)号：US07972543B2
公开(公告)日：2011-07-05
申请号：US11577474
申请日：2005-10-11
IPC分类号： B29B9/00
CPC分类号： B01J13/04 , A23P10/25 , A61K9/1682 , B01F3/0807 , B01F5/0475 , B01F13/0059 , B01F2215/0014 , B01F2215/0016 , B01F2215/0019 , B01F2215/0031 , B01F2215/0034 , B01J13/02 , C25D1/08 , Y10T428/24273
摘要： An object of the present invention is to provide a process for producing microspheres that are solid microparticles or liquid microparticles for use as an emulsion employed in the food industry, production of medicine and cosmetic etc. or an emulsion for DDS (drug delivery system). The object is attained by a process for producing a microsphere including: separating a disperse phase from a continuous phase by a substrate 1 having a through-hole 7; and extruding the disperse phase into the continuous phase through the through-hole 7, in which the substrate having the through-hole 7 with a width of 0.5 to 500 μm, a depth of 10 μm to 6000 μm and a ratio of the width to the depth of the through-hole 7 of 1 to 1/30 is a metal substrate.
摘要翻译： 本发明的目的是提供一种制备用作食品工业中使用的乳液的固体微粒或液体微粒的微球的制造方法，药物和化妆品的制造等，或用于DDS（药物输送系统）的乳液。 该目的通过一种制备微球体的方法来实现，包括：通过具有通孔7的基底1将分散相与连续相分离; 并且通过通孔7将分散相挤出到连续相中，其中具有宽度为0.5至500μm的通孔7的基底，深度为10μm至6000μm，宽度与 通孔7的深度为1〜1/30是金属基板。
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公开(公告)号：US07432110B2
公开(公告)日：2008-10-07
申请号：US11659952
申请日：2005-08-04
IPC分类号： G01N1/18
CPC分类号： B01L3/502761 , B01F3/0807 , B01F5/0453 , B01F5/0456 , B01F13/0059 , B01L3/502707 , B01L2200/0668 , B01L2300/0816 , C12M23/16 , Y10T436/25375
摘要： A microchannel array according to the present invention includes a first substrate 1, and a second substrate 11 bonded to the first substrate 1. Two sets, that is, a set of a first through-hole 9, a first recess 7, and a first groove 8 and a set of a second through-hole 4, a second recess 2, and a second groove 3 are formed on the first substrate 1. The different sets are separated by a partition 5. A cell differentation/proliferation speed after micro-injection can be increased by using such microchannel array.
摘要翻译： 根据本发明的微通道阵列包括第一基板1和结合到第一基板1的第二基板11。 两组，即一组第一通孔9，第一凹槽7和第一凹槽8以及一组第二通孔4，第二凹槽2和第二凹槽3形成在 第一基板1。 不同的集合由分区5分隔。 通过使用这种微通道阵列可以增加微注射后的细胞分化/增殖速度。
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公开(公告)号：US20070276972A1
公开(公告)日：2007-11-29
申请号：US11659952
申请日：2005-08-04
IPC分类号： G06F13/00
CPC分类号： B01L3/502761 , B01F3/0807 , B01F5/0453 , B01F5/0456 , B01F13/0059 , B01L3/502707 , B01L2200/0668 , B01L2300/0816 , C12M23/16 , Y10T436/25375
摘要： A microchannel array according to the present invention includes a first substrate 1, and a second substrate 11 bonded to the first substrate 1. Two sets, that is, a set of a first through-hole 9, a first recess 7, and a first groove 8 and a set of a second through-hole 4, a second recess 2, and a second groove 3 are formed on the first substrate 1. The different sets are separated by a partition 5. A cell differentation/proliferation speed after micro-injection can be increased by using such microchannel array.
摘要翻译： 根据本发明的微通道阵列包括第一基板1和接合到第一基板1的第二基板11.两组，即一组第一通孔9，第一凹槽7和第一基板11。 凹槽8和一组第二通孔4，第二凹槽2和第二凹槽3形成在第一基底1上。不同的组由分隔体5分隔开。微孔之后的细胞分化/ 可以通过使用这种微通道阵列来增加注射。
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公开(公告)号：US06576023B2
公开(公告)日：2003-06-10
申请号：US09791085
申请日：2001-02-22
IPC分类号： B01J1302
CPC分类号： B01F13/0059 , B01F3/0807 , B01F5/0475 , B01F5/0485 , B01J13/04
摘要： A method and an apparatus are provided for efficiently manufacturing microspheres having a uniform particle diameter. The apparatus comprises: case 1 having a lower body 1a and an upper body 1b. A seal ring 3, a first plate 4 which is comprised of a transparent plate such as a glass plate or a plastic plate, an annular spacer 5, an intermediate plate 6 which is comprised of a silicon substrate or the like, an annular spacer 7, a second plate 8 and a seal ring 9 are inserted in this order into a concave portion 2 formed in the lower body 1a. The upper body 1b is superposed thereon. Further, the upper body 1b is attached to the lower body 1a with bolts or the like.
摘要翻译： 提供了一种有效制造具有均匀粒径的微球的方法和装置。 该装置包括：具有下主体1a和上主体1b的壳体1。 密封环3，由透明板如玻璃板或塑料板构成的第一板4，环形间隔件5，由硅衬底等构成的中间板6，环形间隔件7 ，第二板8和密封环9依次插入形成在下体1a中的凹部2中。 上身1b叠置在其上。 此外，上身1b通过螺栓等附接到下身1a。
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7.发明授权Cross-flow microchannel apparatus and method of producing or separating emulsions making use thereof 失效交叉流动微通道装置及其制造或分离乳液的方法公开(公告)号：US06258858B1
公开(公告)日：2001-07-10
申请号：US09260416
申请日：1999-03-01
IPC分类号： B01D1704
CPC分类号： B01F5/0401 , B01D17/041 , B01D17/044 , B01D17/10 , B01D61/18 , B01F3/0807 , B01F3/0865 , B01F5/0206 , B01F5/0475 , B01F13/0059 , B01F2003/0834 , B01F2005/0011 , Y10S366/03 , Y10S516/924 , Y10T137/0329 , Y10T137/87652
摘要： Cross-flow microchannel apparatus for producing emulsions includes a pump 9 and a pump 11 which are driven to respectively supply a continuous phase to a concave portion 4 via a supply pipe 10, a supply hole 6 and a supply port 18 and a dispersed phase to a space between the outside of a base 3 and the inside of a concave portion 2 formed in a case 1 via a supply pipe 12 and a supply hole 7. Then, by applying a predetermined pressure to the dispersed phase, the dispersed phase is formed into fine particles via a microchannels 21 and mixed with the continuous phase, thereby forming emulsions. The emulsions are withdrawn to a tank and so on via a withdrawal port 19, a withdrawal hole 8, and a withdrawal pipe 13 for emulsions. The apparatus can alternatively be used to separate an emulsion by pumping the emulsion within the concave portion 4 via pipe 10, hole 6 and port 18, such that the emulsion is separated via the microchannels 21 into a continuous phase that is withdrawn from the hole 7, and a dispersed phase that is withdrawn from the hole 8.
摘要翻译： 用于制造乳液的横流微通道装置包括泵9和泵11，其被驱动以经由供给管10，供应孔6和供给口18以及分散相分别向凹部4提供连续相， 经由供给管12和供给孔7形成在基体3的外部和形成在壳体1中的凹部2的内部之间的空间。然后，通过对分散相施加规定的压力，形成分散相 通过微通道21成为细颗粒并与连续相混合，从而形成乳液。 乳液经由抽出口19，抽出孔8和用于乳液的抽出管13而被抽出到罐等中。 该装置可以替代地用于通过管道10，孔6和端口18在凹部4内泵送乳液来分离乳液，使得乳液通过微通道21分离成从孔7中取出的连续相 ，以及从孔8中取出的分散相。
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公开(公告)号：US6155710A
公开(公告)日：2000-12-05
申请号：US125403
申请日：1998-08-18
CPC分类号： B01J13/00 , B01F13/0059 , B01F3/08 , B01F3/0807 , B01F3/0865 , B01F5/0206 , B01F5/0401 , B01F5/0475 , B01F2003/0834 , B01F2005/0011
摘要： A dispersed phase (O) supplied inside a bulkhead member (17) through a supply port (14) enters a gap (20) between a plate (16) and a base (18) through a supply port (19) of the base (18) and the dispersed phase (O) having entered the gap (20) then enters a continuous phase (W) through a boundary section (21) by virtue of pressure applied by a pressurizing means such as a pump. Then, the dispersed phase is made into a particle having a predetermined diameter by a microchannel (24) in passing through this boundary section (21), thereby forming an emulsion (E) in which the dispersed phase (O) of the predetermined diameter is dispersed in the continuous phase (W).
摘要翻译： PCT No.PCT / JP96 / 03492 Sec。 371日期1998年8月18日 102（e）1998年8月18日PCT PCT 1996年11月28日PCT公布。 公开号WO97 / 30783 日期1997年8月28日通过供给口（14）在隔板部件（17）内供给的分散相（O）通过供给口（19）进入板（16）和基部（18）之间的间隙（20） ）和已经进入间隙（20）的分散相（O）之后，通过借助诸如泵等加压装置施加的压力，通过边界部分（21）进入连续相（W）。 然后，分散相通过微通道（24）通过该边界部分（21）制成具有预定直径的颗粒，从而形成乳液（E），其中预定直径的分散相（O）为 分散在连续相（W）中。
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公开(公告)号：US06387301B1
公开(公告)日：2002-05-14
申请号：US09460905
申请日：1999-12-14
申请人： Mitsutoshi Nakajima , Yuji Kikuchi , Hiroshi Nabetani , Jihong Tong , Minoru Seki , Shinji Sugiura
发明人： Mitsutoshi Nakajima , Yuji Kikuchi , Hiroshi Nabetani , Jihong Tong , Minoru Seki , Shinji Sugiura
IPC分类号： B01J1302
CPC分类号： B01F13/0059 , B01F3/0807 , B01F17/0021 , B01F17/0028 , B01F17/0057 , B01F17/0064 , B01F2003/0834 , B01F2215/0427 , B01F2215/0431 , B01F2215/0468 , B01F2215/0472
摘要： A method to efficiently and continuously produce microspheres of natural oils and fats having a high melting point, the average particle diameter of which is in dozens of &mgr;m and is uniform, comprising the steps of heating oils and fats having a high melting point to a temperature greater than the melting point thereof to liquify same holding the oils and fats in a liquid state, forming a dispersed phase of the liquid oils and fats, pressurizing the dispersed phase and forming emulsions by dispersing the dispersed phase into a continuous phase via a plurality of microchannels, and isolating microspheres of the oils and fats having a high melting point by removing the continuous phase from the emulsions.
摘要翻译： 一种有效且连续地生产具有高熔点的天然油脂的微球的方法，其平均粒径为数十个，均匀，包括以下步骤：将具有高熔点的油和脂肪加热至温度 大于其熔点以使液体状态下的油和脂肪液化，形成液体油和脂肪的分散相，对分散相加压并通过将分散相分散到连续相中形成乳液，经由多个 微通道，并通过从乳液中除去连续相来分离具有高熔点的油和脂肪的微球。
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公开(公告)号：US06281254B1
公开(公告)日：2001-08-28
申请号：US09260417
申请日：1999-03-01
IPC分类号： B01F308
CPC分类号： B01F13/0059 , B01F3/0807 , B01F5/0475 , B01F2215/0014 , B01F2215/0031 , B01F2215/0032 , Y10S366/03 , Y10S516/924 , Y10T137/0329 , Y10T137/87652
摘要： A microchannel apparatus includes a plural partition walls 4 formed as extensions of plural microchannels 1 toward a continuous phase, and a flow path 5 is formed between adjacent ones of the partition walls 4. A dispersed phase pumped into a continuous phase via each microchannel 1 generates nearly perfect spheres in the course of passing through the microchannel and the flow path 5 in between the partition walls 4, thereby producing emulsions comprising fine and homogenous microspheres.
摘要翻译： 微通道装置包括形成为连续相的多个微通道1的延伸部的多个分隔壁4，并且在相邻的间隔壁4之间形成流路5.经由每个微通道1泵入连续相的分散相产生 在通过微通道和分隔壁4之间的流路5的过程中几乎完美的球体，从而产生包含精细和均匀的微球体的乳液。
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