公开(公告)号：US20080280883A1

公开(公告)日：2008-11-13

申请号：US11575825

申请日：2005-09-23

申请人： Mohammad Salman ,  Pakala Kumara Savithru Sarma ,  Sankaranarayanan Dharmarajan ,  Anita Chugh ,  Suman Gupta

发明人： Mohammad Salman ,  Pakala Kumara Savithru Sarma ,  Sankaranarayanan Dharmarajan ,  Anita Chugh ,  Suman Gupta

IPC分类号： A61K31/551 ,  A61K31/439 ,  C07D221/22 ,  C07D265/30 ,  A61P11/00 ,  A61K31/5375 ,  C07D405/08

CPC分类号： C07D295/088 ,  C07D207/14 ,  C07D211/14 ,  C07D211/42 ,  C07D211/44 ,  C07D211/58 ,  C07D223/04 ,  C07D243/08 ,  C07D295/108 ,  C07D307/81 ,  C07D317/58 ,  C07D401/04 ,  C07D471/08 ,  C07D487/08

摘要： This present invention generally relates to muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US07544708B2

公开(公告)日：2009-06-09

申请号：US10520572

申请日：2003-04-11

申请人： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Shankar Jayram Shetty ,  Sankaranarayanan Dharmarajan ,  Naresh Kumar ,  Arundutt Vishwanatham Silamkoti ,  Anita Chugh

发明人： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Shankar Jayram Shetty ,  Sankaranarayanan Dharmarajan ,  Naresh Kumar ,  Arundutt Vishwanatham Silamkoti ,  Anita Chugh

IPC分类号： A61K31/40 ,  C07D209/44

CPC分类号： C07D401/12 ,  C07D209/52 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

摘要： This invention generally relates to muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0] hexanes, and 2,4,6-trisubstituted derivatives. The invention also relates to pharmaceutical compositions containing the compounds and the methods of treating the diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 具体地，本发明涉及氮杂双环化合物的衍生物，包括例如6-取代的氮杂双环[3.1.0]己烷和2,4,6-三取代的衍生物。 本发明还涉及含有化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

公开(公告)号：US20080319043A1

公开(公告)日：2008-12-25

申请号：US11913599

申请日：2006-05-01

申请人： Mohammad Salman ,  Naresh Kumar ,  Kirandeep Kaur ,  Shelly Aeron ,  Pakala Kumara Savithru Sarma ,  Sankaranarayanan Dharmarajan ,  Anita Mehta ,  Anita Chugh

发明人： Mohammad Salman ,  Naresh Kumar ,  Kirandeep Kaur ,  Shelly Aeron ,  Pakala Kumara Savithru Sarma ,  Sankaranarayanan Dharmarajan ,  Anita Mehta ,  Anita Chugh

IPC分类号： A61K31/4035 ,  C07D209/44

CPC分类号： C07D209/52

摘要： The present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US07446123B2

公开(公告)日：2008-11-04

申请号：US10552455

申请日：2004-01-07

申请人： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Naresh Kumar ,  Sankaranarayanan Dharmarajan ,  Kirandeep Kaur ,  Anita Chugh

发明人： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Naresh Kumar ,  Sankaranarayanan Dharmarajan ,  Kirandeep Kaur ,  Anita Chugh

IPC分类号： A61K31/40 ,  A61K31/4035 ,  C07D209/52

CPC分类号： C07D209/52 ,  C07D403/06

摘要： This invention generally relates to muscarinic receptor antagonists of formula (I) which are useful, among other uses for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病的其它用途。 本发明还涉及含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

公开(公告)号：US20080319002A1

公开(公告)日：2008-12-25

申请号：US11570749

申请日：2004-06-16

申请人： Anita Mehta ,  Mohammad Salman ,  Pakala Kumara Savithru Sarma ,  Anita Chugh ,  Suman Gupta

发明人： Anita Mehta ,  Mohammad Salman ,  Pakala Kumara Savithru Sarma ,  Anita Chugh ,  Suman Gupta

IPC分类号： A61K31/4353 ,  C07D221/04 ,  A61P1/00 ,  A61P13/02 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00

CPC分类号： C07D405/12 ,  C07D405/14

摘要： This present invention generally relates to xanthine derivatives as muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及作为毒蕈碱受体拮抗剂的黄嘌呤衍生物，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US20090176856A1

公开(公告)日：2009-07-09

申请号：US11576066

申请日：2005-09-26

申请人： Anita Mehta ,  Mohammad Salman ,  Pakala Kumara Savithru Sarma ,  Shelly Aeron ,  Anita Chugh ,  Suman Gupta

发明人： Anita Mehta ,  Mohammad Salman ,  Pakala Kumara Savithru Sarma ,  Shelly Aeron ,  Anita Chugh ,  Suman Gupta

IPC分类号： A61K31/403 ,  C07D209/52 ,  A61P13/00 ,  A61P11/00 ,  A61P11/06 ,  A61P3/04 ,  A61P3/10 ,  C07D405/08

CPC分类号： C07D471/08

摘要： This present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US20090105221A1

公开(公告)日：2009-04-23

申请号：US11576096

申请日：2005-09-28

申请人： Mohammad Salman ,  Pakala Kumara Savithru Sarma ,  Arani Pal ,  Anita Chugh ,  Suman Gupta ,  Venkata P. Palle ,  Naresh Kumar ,  Kirandeep Kaur

发明人： Mohammad Salman ,  Pakala Kumara Savithru Sarma ,  Arani Pal ,  Anita Chugh ,  Suman Gupta ,  Venkata P. Palle ,  Naresh Kumar ,  Kirandeep Kaur

IPC分类号： A61K31/55 ,  C07D223/14 ,  C07D405/12 ,  A61P11/00 ,  A61P1/00

CPC分类号： C07D401/12 ,  C07D221/24 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12

摘要： This present invention generally relates to muscarinic receptor antagonists of Formula (I), which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the prepration of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。 本发明还涉及所述化合物的制备方法，包含所公开的化合物的药物组合物，以及通过毒蕈碱受体介导的疾病的治疗方法。

公开(公告)号：US20080262075A1

公开(公告)日：2008-10-23

申请号：US11573804

申请日：2005-08-18

申请人： Mohammad Salman ,  Pakala Kumara Savithru Sarma ,  Sandeep Y. Shelke ,  Anita Chugh ,  Suman Gupta

发明人： Mohammad Salman ,  Pakala Kumara Savithru Sarma ,  Sandeep Y. Shelke ,  Anita Chugh ,  Suman Gupta

IPC分类号： A61K31/40 ,  C07D207/04 ,  A61P11/00 ,  A61P13/00 ,  A61P1/00

CPC分类号： C07D405/06 ,  C07D207/12

摘要： This invention relates to pyrrolidine derivatives, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Processes for the preparation of described compounds, pharmaceutical compositions containing the described compounds and the methods for treating the diseases mediated through muscarinic receptors are also provided.

摘要翻译： 本发明涉及吡咯烷衍生物，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 还提供了制备所述化合物的方法，含有所述化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

公开(公告)号：US07465751B2

公开(公告)日：2008-12-16

申请号：US10540245

申请日：2002-12-23

申请人： Anita Mehta ,  Jang Bahadur Gupta ,  Pakala Kumara Savithru Sarma

发明人： Anita Mehta ,  Jang Bahadur Gupta ,  Pakala Kumara Savithru Sarma

IPC分类号： A61K31/4015 ,  A61K31/4025 ,  C07D207/48 ,  C07D207/12

CPC分类号： C07D405/12 ,  C07D207/12 ,  C07D207/14

摘要： This invention generally relates to the derivatives of 1-substituted-3-pyrroli dines having the structure of Formula (I): The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention. pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及具有式（I）结构的1-取代-3-吡咯烷二醇衍生物：本发明化合物可用作毒蕈碱受体拮抗剂，可用于治疗各种呼吸疾病 ，通过毒蕈碱受体介导的尿路和胃肠道系统。 本发明还涉及制备本发明化合物的方法。 含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。