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1.发明授权1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists 失效1-取代-3-吡咯烷衍生物作为毒蕈碱受体拮抗剂公开(公告)号：US07465751B2
公开(公告)日：2008-12-16
申请号：US10540245
申请日：2002-12-23
IPC分类号： A61K31/4015 , A61K31/4025 , C07D207/48 , C07D207/12
CPC分类号： C07D405/12 , C07D207/12 , C07D207/14
摘要： This invention generally relates to the derivatives of 1-substituted-3-pyrroli dines having the structure of Formula (I): The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention. pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.
摘要翻译： 本发明一般涉及具有式（I）结构的1-取代-3-吡咯烷二醇衍生物：本发明化合物可用作毒蕈碱受体拮抗剂，可用于治疗各种呼吸疾病 ，通过毒蕈碱受体介导的尿路和胃肠道系统。 本发明还涉及制备本发明化合物的方法。 含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。
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![3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonists](/abs-image/US/2008/07/15/US07399779B2/abs.jpg.150x150.jpg)
2.发明授权3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonists 失效用作毒蕈碱受体拮抗剂的3,6-二取代的氮杂双环[3.1.0]己烷衍生物公开(公告)号：US07399779B2
公开(公告)日：2008-07-15
申请号：US10520573
申请日：2002-07-08
IPC分类号： A61K31/403 , C07D209/52
CPC分类号： C07D401/12 , C07D209/52 , C07D403/12 , C07D413/12 , C07D417/12
摘要： This invention generally relates to the derivatives of novel 3,6 disubstituted azabicyclo[3.1.0]hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.
摘要翻译： 本发明一般涉及新的3,6-二取代的氮杂双环[3.1.0]己烷的衍生物。 本发明的化合物是毒蕈碱受体拮抗剂，其特别用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。 本发明还涉及含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。
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3.发明授权Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists 失效取代的氮杂双环己烷衍生物作为毒蕈碱受体拮抗剂公开(公告)号：US07592359B2
公开(公告)日：2009-09-22
申请号：US10552617
申请日：2003-04-10
IPC分类号： A61K31/445 , A61P11/00 , A61P13/00 , C07D211/22
CPC分类号： C07D209/52 , C07D405/06
摘要： This invention generally relates to derivatives of substituted azabicyclo hexanes. The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.
摘要翻译： 本发明一般涉及取代的氮杂双环己烷的衍生物。 本发明化合物可用作毒蕈碱受体拮抗剂，可用于治疗通过毒蕈碱受体介导的呼吸道，尿路和胃肠道系统的各种疾病。 本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。
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![3,6-disubstituted azabicyclo [3.1.0] hexane deriviatives useful as muscarinic receptor antagonists](/abs-image/US/2008/08/12/US07410993B2/abs.jpg.150x150.jpg)
4.发明授权3,6-disubstituted azabicyclo [3.1.0] hexane deriviatives useful as muscarinic receptor antagonists 失效可用作毒蕈碱受体拮抗剂的3,6-二取代的氮杂双环[3.1.0]己烷衍生物公开(公告)号：US07410993B2
公开(公告)日：2008-08-12
申请号：US10524081
申请日：2002-08-09
IPC分类号： A61K31/403 , C07D209/52
CPC分类号： C07D209/02 , C07D209/52
摘要： This invention generally relates to the derivatives of 3,6 disubstituted azabicyclo[3.1.0] hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.
摘要翻译： 本发明一般涉及3,6-二取代的氮杂双环[3.1.0]己烷的衍生物。 本发明的化合物是毒蕈碱受体拮抗剂，其特别用于治疗通过毒蕈碱受体介导的呼吸，尿和胃肠道系统的各种疾病。 本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。
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5.发明授权3,6-Disubstituted azabicyclo derivatives as muscarinic receptor antagonists 失效3,6-二取代的氮杂双环衍生物作为毒蕈碱受体拮抗剂公开(公告)号：US07232835B2
公开(公告)日：2007-06-19
申请号：US10537851
申请日：2002-12-10
申请人： Anita Mehta , Arundutt Viswanatham Silamkoti , Bruhaspathy Miriyala , Sudershan Kumar Arora , Boju Srinivasulu , Bireshwar Mukherjee , Jang Bahadur Gupta
发明人： Anita Mehta , Arundutt Viswanatham Silamkoti , Bruhaspathy Miriyala , Sudershan Kumar Arora , Boju Srinivasulu , Bireshwar Mukherjee , Jang Bahadur Gupta
IPC分类号： A01N43/40 , A01N43/00 , A61K31/445 , A61K31/55 , C07D221/02
CPC分类号： C07D401/06 , C07D209/52 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/14
摘要： This invention relates to derivatives of 3,6-disubstituted azabicyclo compounds. The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.
摘要翻译： 本发明涉及3,6-二取代的氮杂二环化合物的衍生物。 本发明化合物可用作毒蕈碱受体拮抗剂，可用于治疗通过毒蕈碱受体介导的呼吸道，尿路和胃肠道系统的各种疾病。 本发明还涉及含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。
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![1-(4-arylpiperazin-1-yl)-&ohgr;-[N-(&agr;&ohgr;-dicarboximido)]-alkanes useful as uro-selective &agr;1-adrenoceptor blockers](/abs-image/US/2002/07/16/US06420366B1/abs.jpg.150x150.jpg)
6.发明授权1-(4-arylpiperazin-1-yl)-&ohgr;-[N-(&agr;&ohgr;-dicarboximido)]-alkanes useful as uro-selective &agr;1-adrenoceptor blockers 失效可用作尿选择性α1-肾上腺素受体阻断剂的1-（4-芳基哌嗪-1-基）-ω-[N-（α-甲基 - 二羧酰亚氨基）] - 烷烃公开(公告)号：US06420366B1
公开(公告)日：2002-07-16
申请号：US09577788
申请日：2000-05-24
申请人： Nitya Anand , Neelima Sinha , Sanjay Jain , Anita Mehta , Jang Bahadur Gupta
发明人： Nitya Anand , Neelima Sinha , Sanjay Jain , Anita Mehta , Jang Bahadur Gupta
IPC分类号： A61K31495
CPC分类号： C07D207/404 , A61K31/496 , C07D207/408 , C07D211/88 , C07D401/06
摘要： Novel piperzine derivatives substituted on one nitrogen by an aromatic system and on the other nitrogen by (2,5-dioxopyrrolidin)-1-yl) alkanes or (2,6-dioxopiperidin-1-yl) alkanes have been found to exhibit selective &agr;1A adrenergic activity. The compounds are useful for treatment of disease conditions, such as peripheral vascular disease, congestive heart failure, hypertension and especially benign prostatic hypertrophy.
摘要翻译： 已经发现，通过芳族系统在一个氮上取代的新颖的哌嗪衍生物，另一个氮被（2,5-二氧代吡咯烷-1-基）烷烃或（2,6-二氧代哌啶-1-基）烷烃取代，表现出选择性的α1A 肾上腺素能活动 该化合物可用于治疗疾病状况，例如外周血管疾病，充血性心力衰竭，高血压，特别是良性前列腺肥大。
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7.发明授权Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists 失效取代的氮杂双环己烷衍生物作为毒蕈碱受体拮抗剂公开(公告)号：US07517905B2
公开(公告)日：2009-04-14
申请号：US10552456
申请日：2003-04-09
IPC分类号： A61K31/403 , C07D209/52
CPC分类号： C07D209/52
摘要： This invention relates to the derivatives of substituted azabicyclo hexanes. The compounds of this invention can function as muscarinic receptor antagonists and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.
摘要翻译： 本发明涉及取代的氮杂双环己烷的衍生物。 本发明的化合物可用作毒蕈碱受体拮抗剂，可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。 本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。
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8.发明授权Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists 失效含有3,6-二取代的氮杂二环（3.1.0）己烷衍生物的氟磺酰氨基作为毒蕈碱受体拮抗剂公开(公告)号：US07288562B2
公开(公告)日：2007-10-30
申请号：US10525439
申请日：2002-08-23
申请人： Anita Mehta , Jang Bahadur Gupta
发明人： Anita Mehta , Jang Bahadur Gupta
IPC分类号： A61K31/403 , C07D209/52
CPC分类号： C07D209/94 , C07D209/52
摘要： This invention generally relates to the derivatives of novel 3,6 disubstituted azabicyclo[3.1.0] hexane's. The compounds of this invention are MUSCARINIC receptor antagonists which are useful, inter-ail for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through MUSCARINIC receptors. The invention also relates to processes for the preparation of the compounds of the invention, pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through MUSCARINIC receptors.
摘要翻译： 本发明一般涉及新的3,6-二取代的氮杂双环[3.1.0]己烷的衍生物。 本发明的化合物是毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，尿和胃肠道系统的各种疾病。 本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和通过MUSCARINIC受体介导的疾病的治疗方法。
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公开(公告)号：US07501443B2
公开(公告)日：2009-03-10
申请号：US10540062
申请日：2002-12-23
IPC分类号： A61K31/46 , C07D211/18
CPC分类号： C07D209/52 , A61K31/352 , C07D405/12
摘要： This invention generally relates to the derivatives of 3.6-disubstituted azabicyclo [3.1.0] hexanes of the following formula [IA]. The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the :h1ethods for treating the diseases mediated through muscarinic receptors.
摘要翻译： 本发明一般涉及下式[IA]的3.6-二取代的氮杂二环[3.1.0]己烷的衍生物。 本发明化合物可用作毒蕈碱受体拮抗剂，可用于治疗通过毒蕈碱受体介导的呼吸道，尿路和胃肠道系统的各种疾病。 本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和：用于治疗通过毒蕈碱受体介导的疾病的方法。
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10.发明授权3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists 失效3,6-二取代的氮杂双环己烷衍生物作为毒蕈碱受体拮抗剂公开(公告)号：US07488748B2
公开(公告)日：2009-02-10
申请号：US10543585
申请日：2003-01-23
IPC分类号： A61K31/403 , C07D209/52
CPC分类号： C07D401/04 , C07D209/52 , C07D401/06 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/04
摘要： This invention generally relates to derivatives of 3,6 disubstituted azabicyclo hexanes. The compounds of this invention can function as muscarinic receptor antagonists and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.
摘要翻译： 本发明一般涉及3,6-二取代的氮杂双环己烷的衍生物。 本发明的化合物可用作毒蕈碱受体拮抗剂，可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。 本发明还涉及含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。
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