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    Azabicyclo derivatives as muscarinic receptor antagonists
    6.
    发明申请
    Azabicyclo derivatives as muscarinic receptor antagonists 审中-公开
    偶氮二环衍生物作为毒蕈碱受体拮抗剂

    公开(公告)号：US20070021487A1

    公开(公告)日：2007-01-25

    申请号：US10552503

    申请日：2004-01-06

    申请人： Mohammad Salman ,  Naresh Kumar ,  Pakala Sarma ,  Sankaranarayanan Dharmarajan ,  Anita Chugh

    发明人： Mohammad Salman ,  Naresh Kumar ,  Pakala Sarma ,  Sankaranarayanan Dharmarajan ,  Anita Chugh

    IPC分类号： A61K31/403 ,  C07D209/02

    CPC分类号： C07D209/52 ,  C07D403/06

    摘要： This invention generally relates to muscarinic receptor antagonists of formula (I) which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0]hexanes, as well as pharmaceutical compositions containing such compounds and methods of treating diseases mediated through muscarinic receptors.

    摘要翻译： 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，尿和胃肠道系统的各种疾病。 具体地，本发明涉及氮杂二环化合物的衍生物，包括例如6-取代的氮杂双环[3.1.0]己烷，以及含有这些化合物的药物组合物和治疗通过毒蕈碱受体介导的疾病的方法。

    MONOSACCHARIDE DERIVATIVES
    9.
    发明申请
    MONOSACCHARIDE DERIVATIVES 失效
    单糖衍生物

    公开(公告)号：US20070287673A1

    公开(公告)日：2007-12-13

    申请号：US11755164

    申请日：2007-05-30

    申请人： Ashwani Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Rajkumar Shirumalla

    发明人： Ashwani Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Rajkumar Shirumalla

    IPC分类号： A61K31/7008

    CPC分类号： C07H13/12 ,  C07H9/04

    摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

    摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文公开的化合物可用于抑制和预防炎症和相关病理学，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植物排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮， 动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。 含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性 还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

    Monosaccharide derivatives
    10.
    发明授权
    Monosaccharide derivatives 失效
    单糖衍生物

    公开(公告)号：US07790689B2

    公开(公告)日：2010-09-07

    申请号：US11755164

    申请日：2007-05-30

    申请人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Rajkumar Shirumalla

    发明人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Rajkumar Shirumalla

    IPC分类号： A61K31/7008 ,  A61K31/7012 ,  A61K31/34 ,  C07H5/04 ,  C07H5/06 ,  C07D323/02 ,  C07D317/00

    CPC分类号： C07H13/12 ,  C07H9/04

    摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

    摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文公开的化合物可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮， 动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。 含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性 还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。