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公开(公告)号：US11975073B2
公开(公告)日：2024-05-07
申请号：US18341519
申请日：2023-06-26
发明人： Daniel Kenneth Bonner , Rishab R. Shyam , Jamie Simpson , Christopher John Porter , Natalie Trevaskis , Tim Quach , Sifei Han , Luojuan Hu
IPC分类号： A61K47/55 , A61K9/00 , A61K31/573 , A61K47/54
CPC分类号： A61K47/55 , A61K9/0053 , A61K31/573 , A61K47/542
摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
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公开(公告)号：US20220395513A1
公开(公告)日：2022-12-15
申请号：US17881458
申请日：2022-08-04
发明人： Daniel Kenneth Bonner , Rishab R. Shyam , Jamie Simpson , Christopher John Porter , Natalie Trevaskis , Tim Quach , Sifei Han , Luojuan Hu
IPC分类号： A61K31/573 , A61K47/54
摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
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公开(公告)号：US20240245788A1
公开(公告)日：2024-07-25
申请号：US18409546
申请日：2024-01-10
发明人： Daniel Kenneth Bonner , Rishab R. Shyam , Jamie Simpson , Christopher John Porter , Natalie Trevaskis , Tim Quach , Sifei Han , Luojuan Hu
IPC分类号： A61K47/55 , A61K9/00 , A61K31/573 , A61K47/54
CPC分类号： A61K47/55 , A61K9/0053 , A61K31/573 , A61K47/542
摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
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公开(公告)号：US20240050573A1
公开(公告)日：2024-02-15
申请号：US18343554
申请日：2023-06-28
申请人： Monash University
发明人： Christopher John Porter , Jamie Simpson , Natalie Trevaskis , Tim Quach , Sifei Han , Luojuan Hu
IPC分类号： A61K47/54 , A61K31/568 , A61K31/27 , A61K31/365 , A61K31/485 , C07C219/06 , C07C235/36 , C07D307/88 , A61K31/222 , C07C271/24 , C07D489/12 , C07J1/00 , A61K31/165 , A61K9/00 , A61K31/138 , A61K31/167 , A61K45/06
CPC分类号： A61K47/542 , A61K31/568 , A61K31/27 , A61K31/365 , A61K31/485 , C07C219/06 , C07C235/36 , C07D307/88 , A61K31/222 , C07C271/24 , C07D489/12 , C07J1/0029 , A61K31/165 , C07J1/0025 , A61K9/0053 , A61K31/138 , A61K31/167 , A61K45/06 , C07C2602/26
摘要： The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.
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公开(公告)号：US20230338552A1
公开(公告)日：2023-10-26
申请号：US18341519
申请日：2023-06-26
发明人： Daniel Kenneth Bonner , Rishab R. Shyam , Jamie Simpson , Christopher John Porter , Natalie Trevaskis , Tim Quach , Sifei Han , Luojuan Hu
IPC分类号： A61K47/55 , A61K31/573 , A61K9/00 , A61K47/54
CPC分类号： A61K47/55 , A61K31/573 , A61K9/0053 , A61K47/542
摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
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公开(公告)号：US11608345B1
公开(公告)日：2023-03-21
申请号：US16955084
申请日：2018-12-19
发明人： Daniel Kenneth Bonner , Sifei Han , Luojuan Hu , Ketki Karanam , Christopher John Porter , Tim Quach , Rishab R. Shyam , Jamie Simpson , Natalie Trevaskis
IPC分类号： C07D498/18 , A61P37/06
摘要： The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
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