Chlorin e6-folic acid conjugate, preparation method thereof, and a pharmaceutical composition for the treatment of cancer comprising the same
    3.
    发明授权
    Chlorin e6-folic acid conjugate, preparation method thereof, and a pharmaceutical composition for the treatment of cancer comprising the same 有权
    二氢卟吩e6-叶酸结合物,其制备方法和用于治疗癌症的药物组合物

    公开(公告)号:US08735439B2

    公开(公告)日:2014-05-27

    申请号:US12594186

    申请日:2009-04-29

    IPC分类号: C07D487/22

    摘要: The present invention relates to a novel chlorin e6-folic acid conjugate, a preparation method thereof, and a pharmaceutical composition for the treatment of cancer comprising the same, and more particularly, to a novel compound prepared by linking chlorin e6 to folic acid, which effectively produces singlet oxygen in various media and has much better tumor selectivity than the known porphyrin-based photosensitizers, thereby being used effectively in photodynamic therapy for malignant tumors, a preparation method thereof, and a pharmaceutical composition for photodynamic treatment of solid tumors comprising the compound as an active ingredient.

    摘要翻译: 本发明涉及一种新的二氢卟吩e6-叶酸结合物,其制备方法和用于治疗癌症的药物组合物,特别涉及通过将二氢卟酚e6连接到叶酸而制备的新型化合物,其中 有效地在各种培养基中产生单线态氧,并且具有比已知的基于卟啉的光敏剂更好的肿瘤选择性,从而有效地用于恶性肿瘤的光动力学治疗,其制备方法和用于光动力治疗实体瘤的药物组合物,包括化合物 作为活性成分。

    SUPPORTING APPARATUS FOR DISPLAY DEVICE
    4.
    发明申请
    SUPPORTING APPARATUS FOR DISPLAY DEVICE 审中-公开
    支持显示设备的设备

    公开(公告)号:US20100207006A1

    公开(公告)日:2010-08-19

    申请号:US12738922

    申请日:2008-10-15

    申请人: Hyo Jun Kim

    发明人: Hyo Jun Kim

    IPC分类号: F16M13/00

    摘要: Provided is a supporting apparatus for a display device. The supporting apparatus includes a fixing bracket, a set bracket, and a connecting assembly. The set bracket is connected to the display device and is capable of tilting with respect to the fixing bracket. The connecting assembly is connecting the set bracket and the fixing bracket. The connecting assembly includes a tension member generating biasing force over a portion of a tilting range of the display device.

    摘要翻译: 提供了一种用于显示装置的支撑装置。 支撑装置包括固定支架,固定支架和连接组件。 固定支架连接到显示装置,并且能够相对于固定支架倾斜。 连接组件正在连接固定支架和固定支架。 连接组件包括在显示装置的倾斜范围的一部分上产生偏压力的张力构件。

    NOVEL CHLORIN E6-FOLIC ACID CONJUGATE, PREPARATION METHOD THEREOF, AND A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER COMPRISING THE SAME
    5.
    发明申请
    NOVEL CHLORIN E6-FOLIC ACID CONJUGATE, PREPARATION METHOD THEREOF, AND A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER COMPRISING THE SAME 有权
    新氯酸E6-羧酸共聚物,其制备方法和用于治疗包含其的癌症的药物组合物

    公开(公告)号:US20120059018A1

    公开(公告)日:2012-03-08

    申请号:US12594186

    申请日:2009-04-29

    摘要: The present invention relates to a novel chlorin e6-folic acid conjugate, a preparation method thereof, and a pharmaceutical composition for the treatment of cancer comprising the same, and more particularly, to a novel compound prepared by linking chlorin e6 to folic acid, which effectively produces singlet oxygen in various media and has much better tumor selectivity than the known porphyrin-based photosensitizers, thereby being used effectively in photodynamic therapy for malignant tumors, a preparation method thereof, and a pharmaceutical composition for photodynamic treatment of solid tumors comprising the compound.

    摘要翻译: 本发明涉及一种新的二氢卟吩e6-叶酸结合物,其制备方法和用于治疗癌症的药物组合物,特别涉及通过将二氢卟酚e6连接到叶酸而制备的新型化合物,其中 有效地在各种培养基中产生单线态氧,并且具有比已知的基于卟啉的光敏剂更好的肿瘤选择性,从而有效地用于恶性肿瘤的光动力学治疗,其制备方法和用于光动力治疗实体瘤的药物组合物,其包含化合物 。

    PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING CHLORIN E6-FOLIC ACID CONJUGATE COMPOUND AND CHITOSAN
    6.
    发明申请
    PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING CHLORIN E6-FOLIC ACID CONJUGATE COMPOUND AND CHITOSAN 审中-公开
    用于治疗包含氯林E6-乳酸联合化合物和壳多糖的癌症的药物组合物

    公开(公告)号:US20120035180A1

    公开(公告)日:2012-02-09

    申请号:US12594180

    申请日:2009-04-29

    IPC分类号: A61K31/519 A61P35/00

    摘要: The present invention relates to a pharmaceutical composition for the treatment of cancer comprising a chlorin e6-folic acid conjugate compound and chitosan, and more particularly, to a pharmaceutical composition for photodynamic therapy of solid tumors comprising the novel chlorin e6-folic acid conjugate compound or a pharmaceutically acceptable salt thereof and chitosan, in which the novel compound is prepared by linking chlorin e6 to folic acid, and effectively produces singlet oxygen in various media and has much better tumor selectivity than the known porphyrin-based photosensitizers, thereby being used effectively in photodynamic treatment for malignant tumors.

    摘要翻译: 本发明涉及用于治疗癌症的药物组合物,其包含二氢卟吩e6-叶酸结合化合物和壳聚糖,更具体地,涉及一种用于实体瘤的光动力疗法的药物组合物,其包含新的二氢卟吩e6-叶酸结合物或 其药学上可接受的盐和壳聚糖,其中通过将二氢卟酚e6连接到叶酸来制备新化合物,并且在各种培养基中有效产生单线态氧并且具有比已知的基于卟啉的光敏剂更好的肿瘤选择性,从而有效地用于 恶性肿瘤的光动力治疗。

    Methods for Preparing Chlorophyll a and Chlorin e6
    7.
    发明申请
    Methods for Preparing Chlorophyll a and Chlorin e6 有权
    叶绿素a和氯in e6的制备方法

    公开(公告)号:US20100113766A1

    公开(公告)日:2010-05-06

    申请号:US12513225

    申请日:2007-05-03

    IPC分类号: C09B47/00

    CPC分类号: C12P17/182

    摘要: The present invention relates to a method for preparing chlorophyll-a and chlorin e6. This invention extracts chlorophyll-a by use of undisrupted chlorella cells themselves, thereby preparing chlorin e6 from the chlorophyll-a extract. The high contents of chlorophyll-a may be obtained by the pretreatment procedure of chlorella cells themselves selected in this invention. The present method is performed according to relatively simple procedures, and is suitable in the mass production of chlorin e6.

    摘要翻译: 本发明涉及一种叶绿素a和二氢卟酚e6的制备方法。 本发明通过使用未破坏的小球藻细胞本身提取叶绿素a,从而从叶绿素a提取物中制备二氢卟酚e6。 通过本发明中选择的小球藻细胞的预处理程序可以获得高含量的叶绿素-α。 本方法按照相对简单的程序进行,适用于大量生产二氢卟酚e6。

    Methods for preparing chlorophyll a and chlorin e6
    8.
    发明授权
    Methods for preparing chlorophyll a and chlorin e6 有权
    叶绿素a和二氢卟酚e6的制备方法

    公开(公告)号:US08349335B2

    公开(公告)日:2013-01-08

    申请号:US12513225

    申请日:2007-05-03

    CPC分类号: C12P17/182

    摘要: The present invention relates to a method for preparing chlorophyll-a and chlorin e6. This invention extracts chlorophyll-a by use of undisrupted chlorella cells themselves, thereby preparing chlorin e6 from the chlorophyll-a extract. The high contents of chlorophyll-a may be obtained by the pretreatment procedure of chlorella cells themselves selected in this invention. The present method is performed according to relatively simple procedures, and is suitable in the mass production of chlorin e6.

    摘要翻译: 本发明涉及一种叶绿素a和二氢卟酚e6的制备方法。 本发明通过使用未破坏的小球藻细胞本身提取叶绿素-α,从而从叶绿素a提取物中制备二氢卟酚e6。 通过本发明中选择的小球藻细胞的预处理程序可以获得高含量的叶绿素-α。 本方法按照相对简单的程序进行,适用于大量生产二氢卟酚e6。