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16 条记录 (耗时 0.049 秒)

    Novel 2-pyridinecarboxamide derivatives
    3.
    发明申请
    Novel 2-pyridinecarboxamide derivatives 有权
    新型2-吡啶甲酰胺衍生物

    公开(公告)号：US20060258701A1

    公开(公告)日：2006-11-16

    申请号：US10545424

    申请日：2004-02-13

    申请人： Morihiro Mitsuya ,  Makoto Bamba ,  Fumio Sakai ,  Hitomi Watanabe ,  Yasuhiro Sasaki ,  Teruyuki Nishimura ,  Jun-ichi Eiki

    发明人： Morihiro Mitsuya ,  Makoto Bamba ,  Fumio Sakai ,  Hitomi Watanabe ,  Yasuhiro Sasaki ,  Teruyuki Nishimura ,  Jun-ichi Eiki

    IPC分类号： A61K31/4745 ,  A61K31/444 ,  A61K31/4439 ,  C07D498/02 ,  C07D417/14

    CPC分类号： C07D471/04 ,  C07D417/14

    摘要： The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X1 represents a nitrogen atom, sulfur atom, oxygen atom or the like; R1 represents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; R and R3 are the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明涉及具有葡糖激酶活化作用并可用作糖尿病治疗剂的化合物，其由式（I）表示：其中X 1表示氮原子， 硫原子，氧原子等; R 1表示6至10元芳基，5至7元杂芳基等; D表示氧原子或硫原子; R和R 3相同或不同，各自表示氢原子，低级烷基等; 式（II）表示任选取代的5〜7元杂芳基等; 式（III）表示单环或双环杂芳基]或其药学上可接受的盐。

    2-pyridinecarboxamide derivatives
    4.
    发明授权
    2-pyridinecarboxamide derivatives 有权
    2-吡啶甲酰胺衍生物

    公开(公告)号：US08344003B2

    公开(公告)日：2013-01-01

    申请号：US12604835

    申请日：2009-10-23

    申请人： Morihiro Mitsuya ,  Makoto Bamba ,  Fumiko Sakai ,  Hitomi Watanabe ,  Yasuhiro Sasaki ,  Teruyuki Nishimura ,  Jun-ichi Eiki

    发明人： Morihiro Mitsuya ,  Makoto Bamba ,  Fumiko Sakai ,  Hitomi Watanabe ,  Yasuhiro Sasaki ,  Teruyuki Nishimura ,  Jun-ichi Eiki

    IPC分类号： A61K31/4436 ,  C07D417/14 ,  C07D401/14

    CPC分类号： C07D471/04 ,  C07D417/14

    摘要： The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X1 represents a nitrogen atom, sulfur atom, oxygen atom or the like; R1 represents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; R2 and R3 are the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明涉及具有葡糖激酶活化作用并可用作糖尿病治疗剂的化合物，其由式（I）表示：[其中X1表示氮原子，硫原子，氧原子等 ; R1表示6-至10-元芳基，5-至7-元杂芳基等; D表示氧原子或硫原子; R2和R3相同或不同，各自表示氢原子，低级烷基等; 式（II）表示任选取代的5〜7元杂芳基等; 式（III）表示单环或双环杂芳基]或其药学上可接受的盐。

    2-pyridine carboxamide derivatives
    5.
    发明授权
    2-pyridine carboxamide derivatives 有权
    2-吡啶甲酰胺衍生物

    公开(公告)号：US07629362B2

    公开(公告)日：2009-12-08

    申请号：US10545424

    申请日：2004-02-13

    申请人： Morihiro Mitsuya ,  Makoto Bamba ,  Fumiko Sakai ,  Hitomi Watanabe ,  Yasuhiro Sasaki ,  Teruyuki Nishimura ,  Jun-ichi Eiki

    发明人： Morihiro Mitsuya ,  Makoto Bamba ,  Fumiko Sakai ,  Hitomi Watanabe ,  Yasuhiro Sasaki ,  Teruyuki Nishimura ,  Jun-ichi Eiki

    IPC分类号： A61K31/4436 ,  C07D417/14 ,  C07D401/14

    CPC分类号： C07D471/04 ,  C07D417/14

    摘要： The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X1 represents a nitrogen atom, sulfur atom, oxygen atom or the like; R1 represents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; R2 and R3 are the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明涉及具有葡糖激酶活化作用并可用作糖尿病治疗剂的化合物，其由式（I）表示：[其中X1表示氮原子，硫原子，氧原子等 ; R1表示6-至10-元芳基，5-至7-元杂芳基等; D表示氧原子或硫原子; R2和R3相同或不同，各自表示氢原子，低级烷基等; 式（II）表示任选取代的5〜7元杂芳基等; 式（III）表示单环或双环杂芳基]或其药学上可接受的盐。

    Aryloxy-Substituted Benzimidazole Derivatives
    8.
    发明申请
    Aryloxy-Substituted Benzimidazole Derivatives 有权
    芳氧基取代的苯并咪唑衍生物

    公开(公告)号：US20080125429A1

    公开(公告)日：2008-05-29

    申请号：US11666555

    申请日：2005-11-01

    申请人： Noriaki Hashimoto ,  Keiji Takahashi ,  Chisato Nakama ,  Yoshio Ogino ,  Fumiko Sakai ,  Teruyuki Nishimura ,  Jun-ichi Eiki

    发明人： Noriaki Hashimoto ,  Keiji Takahashi ,  Chisato Nakama ,  Yoshio Ogino ,  Fumiko Sakai ,  Teruyuki Nishimura ,  Jun-ichi Eiki

    IPC分类号： A61K31/5377 ,  C07D213/02 ,  C07D221/00 ,  C07D239/06 ,  C07D241/10 ,  C07D295/00 ,  A61P3/10 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/444 ,  A61K31/506 ,  A61K31/497

    CPC分类号： A61K38/31 ,  A61K31/155 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/506 ,  A61K38/28 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D413/06 ,  C07D413/14 ,  A61K2300/00

    摘要： A glucokinase activator is provided; and a treatment and/or a preventive for diabetes, or a treatment and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a treatment and/or a preventive for obesity are provided.The invention relates to a compound of a formula (I): [wherein R1 and R2 represent a hydrogen, etc.; R3 represents a hydrogen atom, a halogen atom, etc.; R4 each independently represents a hydrogen atom, a lower alkyl group, etc.; Q represents a carbon atom, a nitrogen atom or a sulfur atom (the sulfur atom may be mono- or di-substituted with an oxo group); R5 and R6 each represent a hydrogen atom, a lower alkyl group, etc.; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; Z represents an oxygen atom, a sulfur atom or a nitrogen atom; Ar represents an aryl or heteroaryl group optionally mono to tri-substituted with a group selected from the substituent group β; ring A represents a 5- or 6-membered nitrogen-containing heteroaromatic group; m indicates an integer of from 1 to 6; n indicates an integer of from 0 to 3; p indicates an integer of from 0 to 2 (provided that at least two of X1 to X4 are carbon atoms); q indicates 0 or 1] or its pharmaceutically-acceptable salt, which has an effect of glucokinase activation and is useful as a treatment for diabetes.

    摘要翻译： 提供葡糖激酶活化剂; 提供糖尿病的治疗和/或预防，或治疗和/或预防糖尿病如视网膜病，肾病，神经症，缺血性心脏病，动脉硬化，以及进一步的治疗和/或预防肥胖症。 本发明涉及式（I）的化合物：其中R 1和R 2代表氢等; R 3表示氢原子，卤素原子等; R 4各自独立地表示氢原子，低级烷基等; Q表示碳原子，氮原子或硫原子（硫原子可以被氧代基单取代或二取代）。 R 5和R 6各自表示氢原子，低级烷基等; X 1，X 2，X 3和X 4各自独立地表示碳原子或氮原子; Z表示氧原子，硫原子或氮原子; Ar表示任选被选自取代基组β的基团单取代至三取代的芳基或杂芳基; 环A表示5-或6-元含氮杂芳基; m表示1〜6的整数， n表示0〜3的整数， p表示0〜2的整数（条件是X 1〜X 4中的至少2个为碳原子）; q表示0或1]或其药学上可接受的盐，其具有葡糖激酶活化的作用，并且可用作糖尿病的治疗。

    Isoindole derivatives
    9.
    发明授权
    Isoindole derivatives 失效
    异吲哚衍生物

    公开(公告)号：US06777410B2

    公开(公告)日：2004-08-17

    申请号：US10408220

    申请日：2003-04-08

    申请人： Toshio Nagase ,  Tomoharu Iino ,  Yoshiyuki Sato ,  Teruyuki Nishimura ,  Jun-ichi Eiki

    发明人： Toshio Nagase ,  Tomoharu Iino ,  Yoshiyuki Sato ,  Teruyuki Nishimura ,  Jun-ichi Eiki

    IPC分类号： A61K31423

    CPC分类号： C07D498/04

    摘要： This invention relates to compounds represented by the general formula [I] wherein, R represents an azido group, etc., R1 and R2 are the same or different and represent hydrogen atoms, etc., R3 and R4 are the same or different and represent hydrogen atoms, etc., X1 represents an oxygen atom, etc., X2 represents an oxygen atom, etc., Y represents an oxygen atom, etc., and Z represents a condensed aryl group, etc., or a pharmaceutically acceptable salt thereof, preparation processes thereof, and an agent for treating diabetes, a prophylactic agent for chronic complications of diabetes or a drug against obesity, containing, as an effective ingredient, the compound or the pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明涉及由通式[I]表示的化合物，其中R表示叠氮基等，R 1和R 2相同或不同，表示氢原子等，R 3， 和R 4相同或不同，表示氢原子等，X 1表示氧原子等，X 2表示氧原子等，Y表示氧原子等，Z表示缩合 芳基等，或其药学上可接受的盐，其制备方法和用于治疗糖尿病的药物，用于糖尿病慢性并发症的预防剂或抗肥胖药物，其含有作为有效成分的化合物或药学上可接受的盐 其可接受的盐。

    Heterocycle-substituted benzimidazole derivative
    10.
    发明授权
    Heterocycle-substituted benzimidazole derivative 有权
    杂环取代的苯并咪唑衍生物

    公开(公告)号：US07994331B2

    公开(公告)日：2011-08-09

    申请号：US11988592

    申请日：2006-07-12

    申请人： Yoshio Ogino ,  Katsumasa Nonoshita ,  Teruyuki Nishimura ,  Jun-ichi Eiki

    发明人： Yoshio Ogino ,  Katsumasa Nonoshita ,  Teruyuki Nishimura ,  Jun-ichi Eiki

    IPC分类号： C07D413/14 ,  A61K31/44

    CPC分类号： C07D409/14 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14

    摘要： A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein X1 to X4 independently represent a carbon atom or the like; the ring A represents a 5- to 6-membered heteroaryl having 1 to 4 heteroatoms independently selected from the group consisting of a nitrogen atom, a sulfur atom and an oxygen atom; X5 represents an oxygen atom or the like; X represents a carbon atom or the like; Het represents a 5- or 6-membered aliphatic heterocycle; R1 represents an aryl or the like; R2 represents a formyl group or the like; and R3 represents a —C1-6 alkyl or the like. The compound or salt has a glucokinase activation effect and is useful as a therapeutic agent for diabetes.

    摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐：（I）其中X 1至X 4独立地表示碳原子等; 环A表示具有1至4个独立地选自氮原子，硫原子和氧原子的杂原子的5-至6-元杂芳基; X 5表示氧原子等; X表示碳原子等; Het代表5-或6-元脂族杂环; R1表示芳基等; R2表示甲酰基等; 并且R 3表示-C 1-6烷基等。 化合物或盐具有葡糖激酶活化作用，可用作糖尿病的治疗剂。