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    Quinolizinone compound and use thereof as HIV integrase inhibitor
    1.
    发明授权
    Quinolizinone compound and use thereof as HIV integrase inhibitor 有权
    喹诺酮酮化合物及其作为HIV整合酶抑制剂的用途

    公开(公告)号：US07745459B2

    公开(公告)日：2010-06-29

    申请号：US11230330

    申请日：2005-09-20

    申请人： Motohide Satoh ,  Hisateru Aramaki ,  Hiroshi Nakamura ,  Masafumi Inoue ,  Hiroshi Kawakami ,  Hisashi Shinkai ,  Yuji Matsuzaki ,  Kazunobu Yamataka

    发明人： Motohide Satoh ,  Hisateru Aramaki ,  Hiroshi Nakamura ,  Masafumi Inoue ,  Hiroshi Kawakami ,  Hisashi Shinkai ,  Yuji Matsuzaki ,  Kazunobu Yamataka

    IPC分类号： A01N43/90 ,  A61K31/44 ,  C07D455/02

    CPC分类号： C07D471/04 ,  A61K31/4745 ,  A61K31/519 ,  C07D455/02

    摘要： A pharmaceutical agent having an anti-HIV action, particularly, a pharmaceutical agent having an integrase inhibitory action, is provided.The present invention relates to a quinolizinone compound represented by the following formula [I] wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and an anti-HIV agent containing same as an active ingredient. The compound of the present invention has an HIV integrase inhibitory action and is useful as an anti-HIV agent for the prophylaxis or therapy of AIDS. Moreover, by a combined use with other anti-HIV agents such as protease inhibitors, reverse transcriptase inhibitors and the like, the compounds can become a more effective anti-HIV agent. Since the compound has a high inhibitory activity specific for integrases, the compound can provide a safe pharmaceutical agent for human with a fewer side effects.

    摘要翻译： 提供具有抗HIV作用的药剂，特别是具有整合酶抑制作用的药剂。 本发明涉及由下式[I]表示的喹嗪酮化合物，其中各符号如说明书中所定义，其药学上可接受的盐和含有作为活性成分的抗HIV剂。 本发明的化合物具有HIV整合酶抑制作用，可用作预防或治疗AIDS的抗HIV剂。 此外，通过与其它抗HIV剂如蛋白酶抑制剂，逆转录酶抑制剂等的组合使用，化合物可以成为更有效的抗HIV剂。 由于化合物对整合酶具有高的抑制活性，所以化合物可以为人体提供安全的药剂，副作用较少。

    Quinolizinone compound and use thereof as HIV integrase inhibitor
    2.
    发明申请
    Quinolizinone compound and use thereof as HIV integrase inhibitor 有权
    喹诺酮酮化合物及其作为HIV整合酶抑制剂的用途

    公开(公告)号：US20060084665A1

    公开(公告)日：2006-04-20

    申请号：US11230330

    申请日：2005-09-20

    申请人： Motohide Satoh ,  Hisateru Aramaki ,  Hiroshi Nakamura ,  Masafumi Inoue ,  Hiroshi Kawakami ,  Hisashi Shinkai ,  Yuji Matsuzaki ,  Kazunobu Yamataka

    发明人： Motohide Satoh ,  Hisateru Aramaki ,  Hiroshi Nakamura ,  Masafumi Inoue ,  Hiroshi Kawakami ,  Hisashi Shinkai ,  Yuji Matsuzaki ,  Kazunobu Yamataka

    IPC分类号： A61K31/519 ,  C07D455/02 ,  A61K31/4745

    CPC分类号： C07D471/04 ,  A61K31/4745 ,  A61K31/519 ,  C07D455/02

    摘要： A pharmaceutical agent having an anti-HIV action, particularly, a pharmaceutical agent having an integrase inhibitory action, is provided. The present invention relates to a quinolizinone compound represented by the following formula [I] wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and an anti-HIV agent containing same as an active ingredient. The compound of the present invention has an HIV integrase inhibitory action and is useful as an anti-HIV agent for the prophylaxis or therapy of AIDS. Moreover, by a combined use with other anti-HIV agents such as protease inhibitors, reverse transcriptase inhibitors and the like, the compounds can become a more effective anti-HIV agent. Since the compound has a high inhibitory activity specific for integrases, the compound can provide a safe pharmaceutical agent for human with a fewer side effects.

    摘要翻译： 提供具有抗HIV作用的药剂，特别是具有整合酶抑制作用的药剂。 本发明涉及由下式[I]表示的喹嗪酮化合物，其中各符号如说明书中所定义，其药学上可接受的盐和含有作为活性成分的抗HIV剂。 本发明的化合物具有HIV整合酶抑制作用，可用作预防或治疗AIDS的抗HIV剂。 此外，通过与其它抗HIV剂如蛋白酶抑制剂，逆转录酶抑制剂等的组合使用，化合物可以成为更有效的抗HIV剂。 由于化合物对整合酶具有高的抑制活性，所以化合物可以为人体提供安全的药剂，副作用较少。