-
1.发明申请PRODUCTS COMPRISING AN EXTRACELLULAR MATRIX MATERIAL AND OSTEOGENIC PROTEIN 审中-公开包含细胞外基质材料和蛋白质蛋白质的产品公开(公告)号：US20150065425A1
公开(公告)日：2015-03-05
申请号：US14474722
申请日：2014-09-02
申请人： Muffin Incorporated
发明人： Shelley L. Wallace , Amanda F. Taylor , Steven Charlebois , Christine M. Steinhart , Neal E. Fearnot
CPC分类号： A61L27/3633 , A61L27/12 , A61L27/54 , A61L2300/414 , A61L2400/06 , A61L2430/02
摘要： Osteogenic compositions include a decellularized extracellular matrix tissue and bone morphogenic protein, preferably BMP-2. The compositions make beneficial use of the BMP, which can be used at relatively low doses and can bind to native components (e.g., native sulfated glycosaminoglycans such as heparin and/or heparan sulfate) remaining in the decellularized extracellular matrix tissue. Methods for preparation and use of such compositions are also described. The compositions and related methods can be used in the treatment of diseased or damaged bone tissue.
摘要翻译： 成骨组合物包括脱细胞的细胞外基质组织和骨形态发生蛋白，优选BMP-2。 所述组合物有利地使用BMP，其可以以相对低的剂量使用并且可以结合残留在脱细胞的细胞外基质组织中的天然组分（例如天然硫酸化糖胺聚糖如肝素和/或硫酸乙酰肝素）。 还描述了制备和使用这些组合物的方法。 组合物和相关方法可用于治疗患病或受损的骨组织。
-
2.发明申请PRODUCTS COMPRISING AN EXTRACELLULAR MATRIX TISSUE MATERIAL AND OSTEOGENIC PROTEIN 有权包含细胞基质组织材料和蛋白质蛋白质的产品公开(公告)号：US20160263282A1
公开(公告)日：2016-09-15
申请号：US15058329
申请日：2016-03-02
申请人： Muffin Incorporated
发明人： Shelly L. Wallace , Amanda F. Taylor , Steven Charlebois , Christine M. Steinhart , Neal E. Fearnot
CPC分类号： A61L27/3633 , A61L27/12 , A61L27/54 , A61L2300/414 , A61L2400/06 , A61L2430/02
摘要： Osteogenic compositions include a decellularized extracellular matrix tissue and bone morphogenic protein, preferably BMP-2. The compositions make beneficial use of the BMP, which can be used at relatively low doses and can bind to native components (e.g., native sulfated glycosaminoglycans such as heparin and/or heparan sulfate) remaining in the decellularized extracellular matrix tissue. Methods for preparation and use of such compositions are also described. The compositions and related methods can be used in the treatment of diseased or damaged bone tissue.
摘要翻译： 成骨组合物包括脱细胞的细胞外基质组织和骨形态发生蛋白，优选BMP-2。 所述组合物有利地使用BMP，其可以以相对低的剂量使用并且可以结合残留在脱细胞的细胞外基质组织中的天然组分（例如天然硫酸化糖胺聚糖如肝素和/或硫酸乙酰肝素）。 还描述了制备和使用这些组合物的方法。 组合物和相关方法可用于治疗患病或受损的骨组织。
-
3.发明申请公开(公告)号：US20150065947A1
公开(公告)日：2015-03-05
申请号：US14473265
申请日：2014-08-29
申请人： Muffin Incorporated
发明人： Shelley L. Wallace , Amanda F. Taylor , Steven Charlebois , Christine M. Steinhart , Neal E. Fearnot
CPC分类号： A61B17/1662 , A61B17/8805 , A61K35/28 , A61K35/44 , A61L27/3633 , A61L27/365 , A61L27/3808 , A61L27/3834 , A61L27/3886 , A61L2430/02
摘要： Compositions and methods for treating diseased or damaged bone, preferably ischemic and/or necrotic bone, include the use of a combination of endothelial progenitor cells and mesenchymal stem cells, desirably also in conjunction with a collagenous extracellular matrix tissue. Methods for preparation of such compositions are also described.
摘要翻译： 用于治疗患病或受损的骨，优选缺血性和/或坏死性骨的组合物和方法包括使用内皮祖细胞和间充质干细胞的组合，期望还与胶原细胞外基质组织结合。 还描述了制备这种组合物的方法。
-
公开(公告)号：US09993580B2
公开(公告)日：2018-06-12
申请号：US15058329
申请日：2016-03-02
申请人： Muffin Incorporated
发明人： Shelley Lynn Scoville , Amanda F. Taylor , Steven Charlebois , Christine M. Steinhart , Neal E. Fearnot
CPC分类号： A61L27/3633 , A61L27/12 , A61L27/54 , A61L2300/414 , A61L2400/06 , A61L2430/02
摘要： Osteogenic compositions include a decellularized extracellular matrix tissue and bone morphogenic protein, preferably BMP-2. The compositions make beneficial use of the BMP, which can be used at relatively low doses and can bind to native components (e.g., native sulfated glycosaminoglycans such as heparin and/or heparan sulfate) remaining in the decellularized extracellular matrix tissue. Methods for preparation and use of such compositions are also described. The compositions and related methods can be used in the treatment of diseased or damaged bone tissue.
-
-
-
搜索结果
4 条记录 (耗时 0.01 秒)
