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公开(公告)号：US20090143290A1
公开(公告)日：2009-06-04
申请号：US12171112
申请日：2008-07-10
申请人： Mujun Zhao , Zhenhua Xu , Liang Liang , Zaiping Li
发明人： Mujun Zhao , Zhenhua Xu , Liang Liang , Zaiping Li
IPC分类号： A61K38/17 , A61K31/711 , C12Q1/68 , G01N33/567
CPC分类号： C07K14/4703 , A61K38/00
摘要： The invention has disclosed a new tumor suppressor protein HCRP1, the polynucleotide sequences encoding this polypeptides, and methods for production of the polypeptide using the recombinant technology. The tumor suppression protein, HCRP1, is obtained through the positional candidate cloning strategy. It locates in 8p22 region of human chromosome. The full length cDNA for HCRP1 is 1917bp, which encodes a protein of 397 amino acids. When introduced into liver cancer cells, HCRP1 can inhibit the malignant transformation of liver cancer cells.
摘要翻译： 本发明公开了一种新的肿瘤抑制蛋白HCRP1，编码该多肽的多核苷酸序列，以及使用重组技术产生多肽的方法。 通过位置候选克隆策略获得肿瘤抑制蛋白HCRP1。 它位于人类染色体的8p22区域。 HCRP1的全长cDNA为1917bp，编码397个氨基酸的蛋白质。 当引入肝癌细胞时，HCRP1可以抑制肝癌细胞的恶性转化。
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公开(公告)号：US20060116323A1
公开(公告)日：2006-06-01
申请号：US11273593
申请日：2005-11-14
申请人： Mujun Zhao , Zhenhua Xu , Liang Liang , Zaiping Li
发明人： Mujun Zhao , Zhenhua Xu , Liang Liang , Zaiping Li
CPC分类号： C07K14/4703 , A61K38/00
摘要： The invention has disclosed a new tumor suppressor protein HCRP1, the polynucleotide sequences encoding this polypeptides, and methods for production of the polypeptide using the recombinant technology. The tumor suppression protein, HCRP1, is obtained through the positional candidate cloning strategy. It locates in 8p22 region of human chromosome. The full length cDNA for HCRP1 is 1917bp, which encodes a protein of 397 amino acids. When introduced into liver cancer cells, HCRP1 can inhibit the malignant transformation of liver cancer cells.
摘要翻译： 本发明公开了一种新的肿瘤抑制蛋白HCRP1，编码该多肽的多核苷酸序列，以及使用重组技术产生多肽的方法。 通过位置候选克隆策略获得肿瘤抑制蛋白HCRP1。 它位于人类染色体的8p22区域。 HCRP1的全长cDNA为1917bp，编码397个氨基酸的蛋白质。 当引入肝癌细胞时，HCRP1可以抑制肝癌细胞的恶性转化。
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公开(公告)号：US08030015B2
公开(公告)日：2011-10-04
申请号：US12171112
申请日：2008-07-10
申请人： Mujun Zhao , Zhenhua Xu , Liang Liang , Zaiping Li
发明人： Mujun Zhao , Zhenhua Xu , Liang Liang , Zaiping Li
IPC分类号： G01N33/574
CPC分类号： C07K14/4703 , A61K38/00
摘要： The invention has disclosed a new tumor suppressor protein HCRP1, the polynucleotide sequences encoding this polypeptides, and methods for production of the polypeptide using the recombinant technology. The tumor suppression protein, HCRP1, is obtained through the positional candidate cloning strategy. It locates in 8p22 region of human chromosome. The full length cDNA for HCRP1 is 1916 bp, which encodes a protein of 397 amino acids. When introduced into liver cancer cells, HCRP1 can inhibit the malignant transformation of liver cancer cells.
摘要翻译： 本发明公开了一种新的肿瘤抑制蛋白HCRP1，编码该多肽的多核苷酸序列，以及使用重组技术产生多肽的方法。 通过位置候选克隆策略获得肿瘤抑制蛋白HCRP1。 它位于人类染色体的8p22区域。 HCRP1的全长cDNA为1916bp，编码397个氨基酸的蛋白质。 当引入肝癌细胞时，HCRP1可以抑制肝癌细胞的恶性转化。
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公开(公告)号：US20060188973A1
公开(公告)日：2006-08-24
申请号：US11416116
申请日：2006-05-02
申请人： Zhenhua Xu , Eric Wieben , Richard Weinshilboum
发明人： Zhenhua Xu , Eric Wieben , Richard Weinshilboum
CPC分类号： C12N9/12
摘要： Isolated PAPSS1 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PAPSS1 allozymes. Methods for determining if a mammal is predisposed to joint disease or cancer also are described.
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5.发明申请Method for Expanding a Single Chassis Network or Computing Platform Using Soft Interconnects 审中-公开使用软件互连扩展单个机箱网络或计算平台的方法公开(公告)号：US20120257618A1
公开(公告)日：2012-10-11
申请号：US13440805
申请日：2012-04-05
摘要： A system and method for expanding a chassis network using soft interconnects, including a hybrid chassis comprising a first fabric card comprising a first switching fabric, a second fabric card comprising a second switching fabric, a first set of line cards coupled to the first switching fabric via a first set of hard connections, and coupled to an interface associated with the second switching fabric via a soft connection, and a second set of line cards coupled to the second fabric card.
摘要翻译： 一种用于使用软互连来扩展机箱网络的系统和方法，包括混合机架，其包括包括第一交换结构的第一组织卡，包括第二交换结构的第二组织卡，耦合到所述第一交换结构的第一组线卡 经由第一组硬连接，并且经由软连接耦合到与所述第二交换结构相关联的接口，以及耦合到所述第二结构卡的第二组线卡。
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6.发明授权3′-phosphoadenosine-5′-phosphosulfate synthetase 1 (PAPSS1) sequence variants 失效3'-磷酸腺苷-5'-磷酸硫酸合成酶1（PAPSS1）序列变体公开(公告)号：US07288399B2
公开(公告)日：2007-10-30
申请号：US11416116
申请日：2006-05-02
IPC分类号： C12N9/12
CPC分类号： C12N9/12
摘要： Isolated PAPSS1 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PAPSS1 allozymes. Methods for determining if a mammal is predisposed to joint disease or cancer also are described.
摘要翻译： 描述了包含核苷酸序列变体和序列变体侧翼核苷酸的分离的PAPSS1核酸分子，以及PAPSS1同工酶。 还描述了确定哺乳动物是否易患关节疾病或癌症的方法。
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7.发明授权3′-phosphoadenosine -5′-phosphosulfate synthetase 2 (PAPSS2) sequence variants 失效3'-磷酸腺苷-5'-磷酸硫酸合成酶2（PAPSS2）序列变体公开(公告)号：US07186551B1
公开(公告)日：2007-03-06
申请号：US10294397
申请日：2002-11-14
CPC分类号： C12N9/1241
摘要： Isolated PAPSS2 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PAPSS2 allozymes. Methods for determining if a mammal is predisposed to joint disease or cancer also are described.
摘要翻译： 描述包括核苷酸序列变体和序列变体侧翼核苷酸的分离的PAPSS2核酸分子，以及PAPSS2同工酶。 还描述了确定哺乳动物是否易患关节疾病或癌症的方法。
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8.发明授权3′-phosphoadenosine-5′-phosphosulfate synthetase 1 (PAPSS1) sequence variants 失效3'-磷酸腺苷-5'-磷酸硫酸合成酶1（PAPSS1）序列变体公开(公告)号：US07067311B1
公开(公告)日：2006-06-27
申请号：US10294229
申请日：2002-11-14
IPC分类号： C12N15/12
CPC分类号： C12N9/12
摘要： Isolated PAPSS1 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PAPSS1 allozymes. Methods for determining if a mammal is predisposed to joint disease or cancer also are described.
摘要翻译： 描述了包含核苷酸序列变体和序列变体侧翼核苷酸的分离的PAPSS1核酸分子，以及PAPSS1同工酶。 还描述了确定哺乳动物是否易患关节疾病或癌症的方法。
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