公开(公告)号：US20020115119A1

公开(公告)日：2002-08-22

申请号：US09973063

申请日：2001-10-10

Applicant: Myriad Genetics, Inc.

Inventor： Jean-Mark Roch ,  Paul L. Bartel ,  Karen Heichman

IPC: G01N033/567

CPC classification number: G01N33/6896 ,  A61K38/1709 ,  C07K14/47 ,  C07K14/4711 ,  C07K16/18 ,  C07K16/2833 ,  C07K2317/32 ,  C12Q1/6883 ,  C12Q1/6897 ,  C12Q2600/156 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/28 ,  C12Q2565/201

Abstract: The present invention relates to the discovery of protein-protein interactions that are involved in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD). Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of neurodegenerative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

Abstract translation: 本发明涉及发现包括阿尔茨海默氏病（AD）在内的神经变性疾病的发病机理中的蛋白质 - 蛋白质相互作用。 因此，本发明涉及这些蛋白质和/或其片段的复合物，复合物的抗体，神经变性疾病的诊断（包括诊断病因的倾向和诊断），药物筛选调节剂 本文所述的蛋白质的相互作用以及在本文所述的蛋白质共有的途径中鉴定另外的蛋白质。