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    Protein-protein interactions
    1.
    发明申请
    Protein-protein interactions 审中-公开

    公开(公告)号：US20030068630A1

    公开(公告)日：2003-04-10

    申请号：US10105959

    申请日：2002-03-21

    Applicant: Myriad Genetics, Inc.

    Inventor： Daniel M. Cimbora ,  Karen Heichman ,  Paul L. Bartel

    IPC: C12Q001/68 ,  G01N033/53 ,  C12N009/00 ,  C07K016/40

    CPC classification number: C07K14/721 ,  A01K2217/05 ,  C07K14/4705 ,  C07K2319/00

    Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

    Protein-protein interactions
    2.
    发明申请
    Protein-protein interactions 审中-公开

    公开(公告)号：US20030055219A1

    公开(公告)日：2003-03-20

    申请号：US10014799

    申请日：2001-12-14

    Applicant: MYRIAD GENETICS, INC.

    Inventor： Daniel M. Cimbora ,  Karen Heichman ,  Paul L. Bartel

    IPC: C07K014/435 ,  G01N033/53

    CPC classification number: G01N33/6893 ,  G01N2500/00

    Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

    Protein-protein interactions
    5.
    发明申请
    Protein-protein interactions 审中-公开

    公开(公告)号：US20030064408A1

    公开(公告)日：2003-04-03

    申请号：US10035343

    申请日：2002-01-04

    Applicant: MYRIAD GENETICS, INC.

    Inventor： Daniel M. Cimbora ,  Karen Heichman ,  Paul L. Bartel

    IPC: G01N033/53 ,  G01N033/537 ,  G01N033/543 ,  C12N009/12 ,  C07K016/40

    CPC classification number: C12N9/1205 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47

    Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

    MMSC1 - an MMAC1 interacting protein
    6.
    发明申请
    MMSC1 - an MMAC1 interacting protein 审中-公开
    MMSC1 - 一种MMAC1相互作用蛋白

    公开(公告)号：US20030008346A1

    公开(公告)日：2003-01-09

    申请号：US09998425

    申请日：2001-12-03

    Applicant: Myriad Genetics, Inc.

    Inventor： Paul L. Bartel ,  Sean V. Tavtigian

    IPC: C12Q001/68 ,  G01N033/574 ,  C07H021/04 ,  C12N009/16 ,  C12P021/02 ,  C12N005/06

    CPC classification number: C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00

    Abstract: The present invention is directed to the MMSC1 gene, its protein product and the use of the protein to (i) detect mutant MMAC1 proteins, (ii) screen for drugs which can be used for suppressing tumor growth and (iii) identify proteins which interact with the MMAC1 gene or are involved in the tumor suppression pathway of the MMAC1 gene.

    Abstract translation: 本发明涉及MMSC1基因，其蛋白质产物和蛋白质的使用（i）检测突变体MMAC1蛋白，（ii）筛选可用于抑制肿瘤生长的药物，以及（iii）鉴定相互作用的蛋白质 与MMAC1基因或参与MMAC1基因的肿瘤抑制途径。

    Protein-protein interactions
    7.
    发明申请
    Protein-protein interactions 审中-公开

    公开(公告)号：US20020164647A1

    公开(公告)日：2002-11-07

    申请号：US10035344

    申请日：2002-01-04

    Applicant: MYRIAD GENETICS, INC.

    Inventor： Daniel M. Cimbora ,  Karen Heichman ,  Paul L. Bartel

    IPC: G01N033/53

    CPC classification number: C12N9/1085 ,  C07K2319/00 ,  C12N9/1205 ,  C12N15/1055 ,  C12Y205/01029 ,  C12Y207/01037

    Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

    Protein-protein interactions in neurodegenerative diseases
    9.
    发明申请
    Protein-protein interactions in neurodegenerative diseases 审中-公开
    蛋白质 - 蛋白质在神经退行性疾病中的相互作用

    公开(公告)号：US20020115119A1

    公开(公告)日：2002-08-22

    申请号：US09973063

    申请日：2001-10-10

    Applicant: Myriad Genetics, Inc.

    Inventor： Jean-Mark Roch ,  Paul L. Bartel ,  Karen Heichman

    IPC: G01N033/567

    CPC classification number: G01N33/6896 ,  A61K38/1709 ,  C07K14/47 ,  C07K14/4711 ,  C07K16/18 ,  C07K16/2833 ,  C07K2317/32 ,  C12Q1/6883 ,  C12Q1/6897 ,  C12Q2600/156 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/28 ,  C12Q2565/201

    Abstract: The present invention relates to the discovery of protein-protein interactions that are involved in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD). Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of neurodegenerative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

    Abstract translation: 本发明涉及发现包括阿尔茨海默氏病（AD）在内的神经变性疾病的发病机理中的蛋白质 - 蛋白质相互作用。 因此，本发明涉及这些蛋白质和/或其片段的复合物，复合物的抗体，神经变性疾病的诊断（包括诊断病因的倾向和诊断），药物筛选调节剂 本文所述的蛋白质的相互作用以及在本文所述的蛋白质共有的途径中鉴定另外的蛋白质。

    Protein-protein interactions in neurodegenerative disorders
    10.
    发明申请
    Protein-protein interactions in neurodegenerative disorders 审中-公开

    公开(公告)号：US20020059653A1

    公开(公告)日：2002-05-16

    申请号：US09970666

    申请日：2001-10-05

    Applicant: MYRIAD GENETICS, INC.

    Inventor： Jean-Marc Roch ,  Paul L. Bartel

    IPC: A01K067/00 ,  A61K039/395 ,  A61K038/17

    CPC classification number: C07K14/4711 ,  A01K2217/05 ,  C07K2319/00 ,  G01N2333/4719

    Abstract: The present invention relates to the discovery of protein-protein interactions that are involved in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD). Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of neurodegenerative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

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