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1.发明授权公开(公告)号：US09925284B2
公开(公告)日：2018-03-27
申请号：US13982712
申请日：2012-01-31
IPC分类号： A61K51/12 , A61K49/00 , G01N33/543
CPC分类号： A61K51/1244 , A61K49/0067 , A61K49/0089 , G01N33/54346 , G01N33/54353 , G01N33/54393
摘要： The present invention relates to a nanoparticle having a linker connected to a long alkane or alkene chain, and a method for preparing the nanoparticle. The alkyl chain of C10-30 introduced with a ligand of the present invention can be coated on a hydrophobic nanoparticle through a noncovalent bond, enabling easy introduction of various ligands to the nanoparticle, and the nanoparticle having various functional groups prepared using the method can be applied to fluorescent detection, MRI, raman spectroscopy, optical detection, PET, SPECT, or gamma image device, and the ligand of the visualization agents can be modified to be used for new vessels detection, cancer cell detection, immunocyte detection, hepatocyte detection, cell death detection, and gene detection.
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2.发明申请NANOPARTICLE COATED WITH LIGAND INTRODUCED WITH LONG HYDROPHOBIC CHAIN AND METHOD FOR PREPARING SAME 有权用长链疏水链引导的纳米复合材料及其制备方法公开(公告)号：US20140199235A1
公开(公告)日：2014-07-17
申请号：US13982712
申请日：2012-01-31
CPC分类号： A61K51/1244 , A61K49/0067 , A61K49/0089 , G01N33/54346 , G01N33/54353 , G01N33/54393
摘要： The present invention relates to a nanoparticle having a linker connected to a long alkane or alkene chain, and a method for preparing the nanoparticle. The alkyl chain of C10-30 introduced with a ligand of the present invention can be coated on a hydrophobic nanoparticle through a noncovalent bond, enabling easy introduction of various ligands to the nanoparticle, and the nanoparticle having various functional groups prepared using the method can be applied to fluorescent detection, MRI, raman spectroscopy, optical detection, PET, SPECT, or gamma image device, and the ligand of the visualization agents can be modified to be used for new vessels detection, cancer cell detection, immunocyte detection, hepatocyte detection, cell death detection, and gene detection.
摘要翻译： 本发明涉及具有连接到长链烷烃或链烯链上的连接体的纳米粒子，以及制备纳米粒子的方法。 用本发明的配体引入的C10-30的烷基链可以通过非共价键包被在疏水性纳米颗粒上，使得能够容易地将各种配体引入纳米颗粒，并且具有使用该方法制备的各种官能团的纳米颗粒可以是 应用于荧光检测，MRI，拉曼光谱，光学检测，PET，SPECT或γ图像装置，可视化试剂的配体可用于新血管检测，癌细胞检测，免疫细胞检测，肝细胞检测， 细胞死亡检测和基因检测。
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3.发明授权Triazanonane derivatives or pharmaceutically acceptable salt thereof for enhanced fluorine-18 labeling 有权三唑烷衍生物或其药学上可接受的盐，用于增强氟-18标记公开(公告)号：US09012604B2
公开(公告)日：2015-04-21
申请号：US13983053
申请日：2012-02-01
申请人： Jae Min Jeong , Dinesh Shetty , Dong Soo Lee , June-Key Chung , Myung Chul Lee
发明人： Jae Min Jeong , Dinesh Shetty , Dong Soo Lee , June-Key Chung , Myung Chul Lee
CPC分类号： C07D255/02 , A61K51/044 , C07K7/64
摘要： The present invention relates to a triazanonane derivative indicated by the chemical formula 1 below, or a pharmaceutically acceptable salt thereof, and a method for preparing same, and the triazanonane derivative according to the present invention forms a complex with a metal-fluoride and displays an effect of increasing the labeling efficiency up to 78-90% when labeling F-18, thus enabling use in various radioactive medicine labeling (In the chemical formula 1, R1, R2, A. E. X, n and m are as defined in the present description.)
摘要翻译： 本发明涉及由下述化学式1表示的三氮代壬烷衍生物或其药学上可接受的盐及其制备方法，本发明的三氮代烷衍生物与金属氟化物形成络合物，并显示出 当标记F-18时，将标记效率提高至78-90％，从而可用于各种放射性药物标记（化学式1，R1，R2，AE X，n和m如本说明书中所定义） 。）
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4.发明申请TRIAZANONANE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF FOR ENHANCED FLUORINE-18 LABELING 有权三氯苯胺衍生物或药物可接受的盐，用于增强荧光素-18标记公开(公告)号：US20130317196A1
公开(公告)日：2013-11-28
申请号：US13983053
申请日：2012-02-01
申请人： Jae Min Jeong , Dinesh Shetty , Dong Soo Lee , June-Key Chung , Myung Chul Lee
发明人： Jae Min Jeong , Dinesh Shetty , Dong Soo Lee , June-Key Chung , Myung Chul Lee
IPC分类号： C07D255/02 , A61K51/04 , C07K7/64
CPC分类号： C07D255/02 , A61K51/044 , C07K7/64
摘要： The present invention relates to a triazanonane derivative indicated by the chemical formula 1 below, or a pharmaceutically acceptable salt thereof, and a method for preparing same, and the triazanonane derivative according to the present invention forms a complex with a metal-fluoride and displays an effect of increasing the labeling efficiency up to 78-90% when labeling F-18, thus enabling use in various radioactive medicine labeling (In the chemical formula 1, R1, R2, A. E. X, n and m are as defined in the present description.)
摘要翻译： 本发明涉及由下述化学式1表示的三氮代壬烷衍生物或其药学上可接受的盐及其制备方法，本发明的三氮代烷衍生物与金属氟化物形成络合物，并显示出 当标记F-18时，将标记效率提高至78-90％，从而可用于各种放射性药物标记（化学式1，R1，R2，AE X，n和m如本说明书中所定义） 。）
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5.发明申请Benzylideneaniline derivatives and their radioisotope labeled compounds for binding and imaging of beta-amyloid plaques 审中-公开苯亚甲基苯胺衍生物及其放射性同位素标记化合物，用于结合和成像β-淀粉样蛋白斑公开(公告)号：US20070122341A1
公开(公告)日：2007-05-31
申请号：US11424741
申请日：2006-06-16
申请人： Jae Min Jeong , Dong Soo Lee , June-Key Chung , Myung Chul Lee
发明人： Jae Min Jeong , Dong Soo Lee , June-Key Chung , Myung Chul Lee
IPC分类号： A61K51/00 , C07D249/02
CPC分类号： A61K51/04 , C07C251/24
摘要： Benzylideneaniline derivatives of formula 1 wherein R1-R5 are independently selected from hydrogen, C1-C4 alkyl and F (at least one of them is F) and each R6-R10 are independently selected from hydrogen, C1-C4 alkyl, OH, OCH3, NH2, NHCH3 and N(CH3)2 (at least one of them is OH, OCH3, NH2, NHCH3 or N(CH3)2) are disclosed. Benzylideneaniline derivatives according to the present invention have high affinity to β-amyloid plaques. Thus, they can cross the blood-brain-barrier (BBB) and bind to β-amyloid plaques after administration into the body, making them useful for treatment, prevention, or imaging of Alzheimer's disease.
摘要翻译： 式1的亚苄基苯胺衍生物，其中R 1 -R 5独立地选自氢，C 1 -C 4烷基和F（其中至少一个为F） 取代基，其中R 1，R 2，R 2，R 3，R 4，R 6， 3，NH 2，NHCH 3和N（CH 3）2）（至少一个 它们是OH，OCH 3，NH 2，NHCH 3或N（CH 3 3） 2 ）。 根据本发明的亚苄基苯胺衍生物对β-淀粉样蛋白斑具有高亲和力。 因此，它们可以穿过血脑屏障（BBB）并且在施用于体内后与β-淀粉样蛋白斑结合，使其可用于治疗，预防或成像阿尔茨海默氏病。
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6.发明授权Diaminedithiol derivatives and radiorhenium or radiotechnetium complex thereof; a liver cancer-treating composition comprising the radiorhenium complex and lipiodol; and a kit for preparation of the liver cancer-treating composition 有权二硫代二醇衍生物及其镭或镭鎓络合物; 包含镭配合物和碘油的肝癌治疗组合物; 以及用于制备肝癌治疗组合物的试剂盒公开(公告)号：US07067508B2
公开(公告)日：2006-06-27
申请号：US10469198
申请日：2002-03-08
申请人： Jae Min Jeong , Young Ju Kim , Yun-Sang Lee , Dong Soo Lee , June-Key Chung , Myung Chul Lee
发明人： Jae Min Jeong , Young Ju Kim , Yun-Sang Lee , Dong Soo Lee , June-Key Chung , Myung Chul Lee
CPC分类号： C07D285/00 , C07C323/41 , C07F13/005 , Y02P20/55
摘要： The present invention relates to a novel diaminedithiol derivative or a pharmaceutically acceptable salt thereof; radiorhenium or radiotechneticum complex thereof; a composition for treating liver cancer comprising the radiorhenium complex and lipiodol; and, a preparative kit of the composition for treating liver cancer.In the composition according to the invention, the diaminedithiol derivative is a novel compound in which long chain alkyl groups were introduced to diaminedithiol, capable of forming a radiorhenium or radiotechnetium complex thereof with an ease and leading to stronger van der Waals bonds with lipiodol. As a result, the complex becomes more stable in a medium, lipiodol, whereby the composition of the invention exhibits a high accumulation rate in liver cancer tissue when injected via hepatic artery, thereby capable of achieving an efficient treatment of liver cancer.
摘要翻译： 本发明涉及一种新的二硫二硫醇衍生物或其药学上可接受的盐; 镭或其无机技术复合物; 用于治疗肝癌的组合物，其包含铑络合物和碘油; 和用于治疗肝癌的组合物的制备试剂盒。 在本发明的组合物中，二硫二硫醇衍生物是一种新的化合物，其中长链烷基被引入到二硫代二醇中，能够容易地形成其镭或镭鎓络合物，并导致与碘碘醇更强的范德华力键。 结果，复合物在培养基，碘油中变得更稳定，由此本发明的组合物通过肝动脉注射时在肝癌组织中表现出高的积累速率，从而能够实现肝癌的有效治疗。
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7.发明授权公开(公告)号：US08911706B2
公开(公告)日：2014-12-16
申请号：US13146280
申请日：2010-01-27
申请人： Jae Min Jeong , Myung Chul Lee , June Key Chung , Dong Soo Lee
发明人： Jae Min Jeong , Myung Chul Lee , June Key Chung , Dong Soo Lee
CPC分类号： A61K51/081 , A61K51/0482
摘要： The present invention is about bifunctional chelating agents (BCA) conjugated mannosyl human serum albumin (MSA) and its radioisotope labeled compounds for imaging immune system such as macrophages, Kupffer cells, reticuloendothelial system (RES), and lymphatic system. The present invention comprises BCA-MSA conjugates, their radiolabeled compounds, and kits for radiolabeing. The present invention improved radiolabeling procedure, showed higher lymphatic system uptake, and enabled image by positron emission tomography (PET).
摘要翻译： 本发明涉及双功能螯合剂（BCA）共轭甘露糖基人血清白蛋白（MSA）及其放射性同位素标记化合物，用于成像免疫系统如巨噬细胞，枯否细胞，网状内皮系统（RES）和淋巴系统。 本发明包括BCA-MSA缀合物，它们的放射性标记化合物和放射性试剂盒。 本发明改善放射性标记程序，显示较高的淋巴系统摄取，并通过正电子发射断层扫描（PET）实现图像。
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8.发明申请HETEROCYCLE-AMINO ACID DERIVATIVES FOR TARGETING CANCER TISSUE AND RADIOACTIVE OR NON-RADIOACTIVE LABELED COMPOUNDS THEREOF 审中-公开用于靶向癌组织和放射性或非放射性标记化合物的杂合氨基酸衍生物公开(公告)号：US20120029177A1
公开(公告)日：2012-02-02
申请号：US13262043
申请日：2010-03-31
申请人： Jae Min Jeong , Dinesh Shetty , Dong Soo Lee , June Key Chung , Myung Chul Lee
发明人： Jae Min Jeong , Dinesh Shetty , Dong Soo Lee , June Key Chung , Myung Chul Lee
IPC分类号： C07D255/02 , C07F1/08 , C07F5/00 , C07F13/00 , C07F15/04 , C07F15/06 , C07F17/00 , C07F11/00 , C07D257/02 , C07F15/02
CPC分类号： C07F13/005 , C07D255/02 , C07D257/02
摘要： The present invention relates to novel amino acid derivatives containing heterocyclic chelating residues thereof; radioactive or nonradioactive metal complexes thereof; methods for preparation thereof; and apyrogenic and sterile preparative kits of the composition for targeting cancer cells.The compounds of the present invention can easily be taken up to cancer cells as they contain amino acid residues thereof; radioactive or nonradioactive metals can be labeled easily as they contain heterocyclic chelating residues thereof; cancer lesion can be imaged easily by targeting using the present invention.
摘要翻译： 本发明涉及含有杂环螯合残基的新型氨基酸衍生物; 放射性或非放射性的金属络合物; 制备方法; 以及用于靶向癌细胞的组合物的致神经和无菌制备试剂盒。 本发明的化合物可容易地被摄入癌细胞，因为它们含有氨基酸残基; 放射性或非放射性金属可以容易地标记，因为它们含有杂环螯合残基; 可以通过使用本发明的靶向容易地成像癌症病变。
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9.发明申请公开(公告)号：US20110286920A1
公开(公告)日：2011-11-24
申请号：US13146280
申请日：2010-01-27
申请人： Jae Min Jeong , Myung Chul Lee , June Key Chung , Dong Soo Lee
发明人： Jae Min Jeong , Myung Chul Lee , June Key Chung , Dong Soo Lee
IPC分类号： A61K51/08 , C07K14/765
CPC分类号： A61K51/081 , A61K51/0482
摘要： The present invention is about bifunctional chelating agents (BCA) conjugated mannosyl human serum albumin (MSA) and its radioisotope labeled compounds for imaging immune system such as macrophages, Kupffer cells, reticuloendothelial system (RES), and lymphatic system. The present invention comprises BCA-MSA conjugates, their radiolabeled compounds, and kits for radiolabeing. The present invention improved radiolabeling procedure, showed higher lymphatic system uptake, and enabled image by positron emission tomography (PET).
摘要翻译： 本发明涉及双功能螯合剂（BCA）共轭甘露糖基人血清白蛋白（MSA）及其放射性同位素标记化合物，用于成像免疫系统如巨噬细胞，枯否细胞，网状内皮系统（RES）和淋巴系统。 本发明包括BCA-MSA缀合物，它们的放射性标记化合物和放射性试剂盒。 本发明改善放射性标记程序，显示较高的淋巴系统摄取，并通过正电子发射断层扫描（PET）实现图像。
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公开(公告)号：US06688257B2
公开(公告)日：2004-02-10
申请号：US10131457
申请日：2002-04-23
申请人： Myung Chul Lee
发明人： Myung Chul Lee
IPC分类号： A01K1300
CPC分类号： A01K13/001
摘要： Provided are a batch-style or selective-style pet dog washing apparatus implemented by automatic control of a sensor and a driver, and a method for controlling the same. The apparatus includes a supporting base for placing a pet dog to be washed thereon and supporting the pet dog, a washer installed in the vicinity of the pet dog, for washing the pet dog by rubbing the same, a component controller for sensing the positions of the pet dog and the washer, adjusting the height of the supporting base according to the size of the pet dog, varying the position of the washer to get close to the pet dog, and actuating the washer, and a cleaning liquid/air supplier for supplying a cleaning liquid and air to the washer.
摘要翻译： 提供了通过传感器和驱动器的自动控制实现的批量式或选择式宠物狗洗涤装置及其控制方法。 该装置包括：用于放置待洗涤的宠物狗并支撑宠物狗的支撑座;安装在宠物狗附近的洗衣机，用于通过摩擦宠物狗来洗涤宠物狗;组件控制器，用于感测宠物狗的位置 宠物狗和洗衣机，根据宠物狗的尺寸调节支撑座的高度，改变洗衣机的位置以接近宠物狗，并致动洗衣机;以及清洁液体/空气供应器 向洗衣机供应清洁液体和空气。
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