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公开(公告)号：US20190233519A1
公开(公告)日：2019-08-01
申请号：US16341034
申请日：2017-10-10
发明人： Yafeng ZHANG , Shu WU , Shuai YANG , Chuan-Chu CHOU
IPC分类号： C07K16/28 , A61K39/395 , A61K47/68 , A61P35/00 , A61K47/65
CPC分类号： C07K16/2818 , A61K39/3955 , A61K47/65 , A61K47/6849 , A61K2039/505 , A61K2039/507 , A61P31/00 , A61P35/00 , C07K16/2827 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes CTLA-4. Also provided are methods of making and using these constructs.
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公开(公告)号：US20240279318A1
公开(公告)日：2024-08-22
申请号：US18560661
申请日：2022-05-31
发明人： Mingxin LI , Zhigang LI , Shuai YANG , Ming ZENG , Sujuan Wang , Lan XU , Shu Wu
IPC分类号： C07K16/18 , A61K39/00 , C07K14/705 , C07K14/725 , C07K16/28 , C12N5/0783
CPC分类号： C07K16/18 , A61K39/4611 , A61K39/4631 , A61K39/4644 , C07K14/7051 , C07K14/70521 , C07K14/70578 , C07K16/2833 , C12N5/0636 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/622 , C07K2317/92 , C07K2319/02 , C12N2510/00
摘要： This disclosure relates to antibodies, antigen-binding fragments, protein constructs, and chimeric antigen receptors that bind to a complex comprising an AFP peptide and an MHC molecule, and the uses thereof.
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公开(公告)号：US20240124580A1
公开(公告)日：2024-04-18
申请号：US18397363
申请日：2023-12-27
发明人： Wang ZHANG , Shu WU , Shuai YANG , Qi PAN , Chuan-Chu CHOU
CPC分类号： C07K16/2803 , A61P35/00 , C07K16/2818 , C07K16/2827 , A61K2039/505
摘要： The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes TIGIT. Also provided are methods of making and using these constructs.
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公开(公告)号：US20220033481A1
公开(公告)日：2022-02-03
申请号：US16755268
申请日：2017-10-11
发明人： Yafeng ZHANG , Shu WU , Fei SUN , Shuai YANG , Chuan-Chu CHOU
摘要： Novel antibodies, such as single domain antibodies (sdAbs), or antigen-binding fragments thereof that specifically bind a transferrin are described. Compositions, methods and systems for increasing the half-life of a target protein in a serum using an antibody or fragment thereof against a transferrin are also described.
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公开(公告)号：US20210054071A1
公开(公告)日：2021-02-25
申请号：US16958397
申请日：2018-12-28
发明人： Wang ZHANG , Shu WU , Shuai YANG , Qi PAN , Chuan-Chu CHOU
摘要： Provided are constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes TIGIT. Also provided are methods of making and using these constructs.
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公开(公告)号：US20210269537A1
公开(公告)日：2021-09-02
申请号：US17270970
申请日：2019-08-29
发明人： Qing DAI , Jian LIU , Shuai YANG , Kun JIANG , Yuanyuan PENG , Chen HU , Shu WU
IPC分类号： C07K16/28 , C07K14/725 , C07K16/30 , A61P35/00 , A61K35/17 , C07K14/705 , C07K14/71
摘要： Described herein are T cells engineered to express a chimeric antigen receptor (CAR), such as an anti-mesothelin CAR alone or in combination with a follicle-stimulating hormone receptor (FSHR) binding domain and/or a dominant negative transforming growth factor-β receptor II (dnTGFβRII) for the treatment of diseases associated with mesothelin expression. Also described are T cells engineered to express a modified T cell receptor (TCR).
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公开(公告)号：US20210017279A1
公开(公告)日：2021-01-21
申请号：US17043054
申请日：2019-03-29
发明人： Wang Zhang , Shuai YANG , Shu WU , Chuan-Chu CHOU
摘要： The present application provides anti-LAG-3 constructs comprising a single-domain antibody (sdAb) that specifically recognizes LAG-3. Also provided are methods of making and using these constructs.
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公开(公告)号：US20200347135A1
公开(公告)日：2020-11-05
申请号：US16962023
申请日：2019-01-15
发明人： Yafeng ZHANG , Shu WU , Shuai YANG , Chuan-Chu CHOU
IPC分类号： C07K16/28
摘要： Provided are constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes PD-1. Also provided are methods of making and using these constructs.
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公开(公告)号：US20210221891A1
公开(公告)日：2021-07-22
申请号：US16764411
申请日：2018-11-13
发明人： Yafeng ZHANG , Shu WU , Shuai YANG , Chuan-Chu CHOU
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395 , A61P35/00
摘要： The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes PD-L1. Also provided are methods of making and using these constructs.
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公开(公告)号：US20210095028A1
公开(公告)日：2021-04-01
申请号：US15733364
申请日：2019-01-15
发明人： Xinpo JIANG , Shuai YANG , Chuan-Chu CHU
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06 , A61P35/00
摘要： The present application provides an antibody, such as a monoclonal antibody (mAb), or an antigen binding fragment thereof, that specifically recognizes TIGIT. Also provided are pharmaceutical compositions, or methods of making and using the antibody or antigen-binding fragment thereof.
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