公开(公告)号：US20150037786A1

公开(公告)日：2015-02-05

申请号：US13959304

申请日：2013-08-05

申请人： NANOSCOPIA (CAYMAN), INC.

发明人： Kenneth Edward Salsman

IPC分类号： G01N35/00

CPC分类号： G02B21/16 ,  B01L3/502 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/027 ,  B01L2300/0654 ,  B01L2300/0864 ,  B01L2300/12 ,  G01N35/00 ,  G01N35/00732 ,  G01N35/04 ,  G01N2035/00772 ,  G01N2035/00801 ,  G01N2035/0436 ,  G02B21/0008 ,  H01L27/14643 ,  Y10T436/25

摘要： A handheld diagnostic system may include a disposable sample holder for receiving and containing a biological sample and an analysis module having a chip-scale microscope. The sample holder may include a plurality of uniformly spaced tick marks. The analysis module may include a sensor for detecting the tick marks as the sample holder is inserted into the analysis module. The chip-scale microscope may include an image sensor for capturing images of the sample. Each time the sensor detects a tick mark, control circuitry may issue a control signal to the image sensor to capture an image of the biological sample. This type of automated image capture mechanism ensures that images are captured at a uniform spatial distribution even when the sample holder is inserted into the analysis module at variable speed. The analysis module may transmit sample imaging data to a portable electronic device.

摘要翻译： 手持式诊断系统可以包括用于接收和容纳生物样品的一次性样品保持器和具有芯片级显微镜的分析模块。 样品保持器可以包括多个均匀间隔的刻度线。 分析模块可以包括用于在样本保持器插入到分析模块中时检测刻度线的传感器。 芯片级显微镜可以包括用于捕获样品图像的图像传感器。 每当传感器检测到刻度标记时，控制电路可以向图像传感器发出控制信号以捕获生物样品的图像。 这种类型的自动图像捕获机构确保即使当样品架以可变的速度插入分析模块中时也能以均匀的空间分布捕获图像。 分析模块可以将样本成像数据发送到便携式电子设备。

公开(公告)号：US09347962B2

公开(公告)日：2016-05-24

申请号：US13959304

申请日：2013-08-05

申请人： NANOSCOPIA (CAYMAN), INC.

发明人： Kenneth Edward Salsman

IPC分类号： G01N35/00 ,  G01N35/04 ,  G02B21/00 ,  B01L3/00

CPC分类号： G02B21/16 ,  B01L3/502 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/027 ,  B01L2300/0654 ,  B01L2300/0864 ,  B01L2300/12 ,  G01N35/00 ,  G01N35/00732 ,  G01N35/04 ,  G01N2035/00772 ,  G01N2035/00801 ,  G01N2035/0436 ,  G02B21/0008 ,  H01L27/14643 ,  Y10T436/25

摘要： A handheld diagnostic system may include a disposable sample holder for receiving and containing a biological sample and an analysis module having a chip-scale microscope. The sample holder may include a plurality of uniformly spaced tick marks. The analysis module may include a sensor for detecting the tick marks as the sample holder is inserted into the analysis module. The chip-scale microscope may include an image sensor for capturing images of the sample. Each time the sensor detects a tick mark, control circuitry may issue a control signal to the image sensor to capture an image of the biological sample. This type of automated image capture mechanism ensures that images are captured at a uniform spatial distribution even when the sample holder is inserted into the analysis module at variable speed. The analysis module may transmit sample imaging data to a portable electronic device.

摘要翻译： 手持式诊断系统可以包括用于接收和容纳生物样品的一次性样品保持器和具有芯片级显微镜的分析模块。 样品保持器可以包括多个均匀间隔的刻度线。 分析模块可以包括用于在样本保持器插入到分析模块中时检测刻度线的传感器。 芯片级显微镜可以包括用于捕获样品图像的图像传感器。 每当传感器检测到刻度标记时，控制电路可以向图像传感器发出控制信号以捕获生物样品的图像。 这种类型的自动图像捕获机构确保即使当样品架以可变的速度插入分析模块中时也能以均匀的空间分布捕获图像。 分析模块可以将样本成像数据发送到便携式电子设备。

公开(公告)号：US20150035966A1

公开(公告)日：2015-02-05

申请号：US13959491

申请日：2013-08-05

申请人： NANOSCOPIA (CAYMAN), INC.

发明人： Kenneth Edward Salsman

IPC分类号： G02B21/36

CPC分类号： G02B21/34 ,  G02B21/0008

摘要： A handheld diagnostic system may include a disposable sample holder and an analysis module having a chip-scale microscope. The sample holder may have a transparent portion having test chambers for containing respective portions of a biological sample. The analysis module may having a housing with an opening configured to receive the transparent portion of the sample holder. The chip-scale microscope may include an image sensor for capturing images of the biological sample as the transparent portion of the sample holder is inserted into the opening of the analysis module. The analysis module may include a light source for illuminating the sample during image capture operations and optics for gathering light from the sample and focusing the light onto the image sensor. The analysis module may transmit sample imaging information to a portable electronic device, which may in turn display corresponding sample analysis information for a user.

摘要翻译： 手持式诊断系统可以包括一次性样品保持器和具有芯片级显微镜的分析模块。 样品保持器可以具有透明部分，其具有用于容纳生物样品的各部分的测试室。 分析模块可以具有壳体，其具有构造成接收样品架的透明部分的开口。 芯片尺度显微镜可以包括用于在样品保持器的透明部分插入分析模块的开口中时捕获生物样品的图像的图像传感器。 分析模块可以包括用于在图像捕获操作期间照亮样品的光源和用于收集来自样品的光并将光聚焦到图像传感器上的光学器件。 分析模块可以将样本成像信息发送到便携式电子设备，便携式电子设备可以依次显示用户的相应样本分析信息。

公开(公告)号：US20150036131A1

公开(公告)日：2015-02-05

申请号：US13959122

申请日：2013-08-05

申请人： NANOSCOPIA ( CAYMAN), INC.

发明人： Kenneth Edward Salsman

IPC分类号： G01N21/01

CPC分类号： G02B21/0008 ,  G02B21/0088 ,  G02B21/34 ,  G02B21/365

摘要： A handheld diagnostic system may include a disposable sample holder and an analysis module having a chip-scale microscope. The sample holder may have a transparent portion that may be inserted into the analysis module. The transparent portion may have test chambers for containing respective portions of a biological sample. The transparent portion may also include built-in reference features such as reference surfaces, reference markings, and/or reference structures. The chip-scale microscope may include an image sensor for capturing images of the sample and the reference features as the sample holder is inserted into the analysis module. Images of the reference features may be compared with images of the sample and may be used to determine the color, opacity, reflectivity, cell size, and/or cell concentration associated with the sample. The analysis module may transmit sample imaging data to a portable electronic device.

摘要翻译： 手持式诊断系统可以包括一次性样品保持器和具有芯片级显微镜的分析模块。 样品保持器可以具有可以插入到分析模块中的透明部分。 透明部分可以具有用于容纳生物样品的相应部分的测试室。 透明部分还可以包括诸如参考表面，参考标记和/或参考结构的内置参考特征。 芯片级显微镜可以包括用于在将样品保持器插入分析模块中时用于捕获样品的图像和参考特征的图像传感器。 可以将参考特征的图像与样本的图像进行比较，并且可以用于确定与样品相关联的颜色，不透明度，反射率，细胞大小和/或细胞浓度。 分析模块可以将样本成像数据发送到便携式电子设备。