公开(公告)号：US20190219519A1

公开(公告)日：2019-07-18

申请号：US16312990

申请日：2017-06-27

申请人： The Regents of the University of California

发明人： Wan Li ,  Seonah Moon ,  Michal Wojcik ,  Ke Xu

IPC分类号： G01N21/892 ,  G01N21/45 ,  G01N21/84 ,  G02B21/00 ,  G02B21/32

CPC分类号： G01N21/892 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  G01N13/00 ,  G01N21/45 ,  G01N21/8422 ,  G01N33/00 ,  G01N2021/8427 ,  G01N2033/0096 ,  G02B21/0016 ,  G02B21/0088 ,  G02B21/32

摘要： The disclosure provides methods for the direct optical visualization of graphene and its nanoscale defects on transparent substrates.

公开(公告)号：US20180252907A1

公开(公告)日：2018-09-06

申请号：US15970719

申请日：2018-05-03

申请人： DISCOVER ECHO INC.

发明人： Eugene L. Cho

IPC分类号： G02B21/00 ,  G02B21/26 ,  G02B21/24 ,  G02B21/08 ,  G02B21/36 ,  G02B21/34 ,  G02B21/02

CPC分类号： G02B21/0088 ,  G02B21/02 ,  G02B21/086 ,  G02B21/24 ,  G02B21/241 ,  G02B21/242 ,  G02B21/26 ,  G02B21/34 ,  G02B21/362 ,  G02B21/368 ,  Y10T29/49002

摘要： A standing microscope is provided that includes a desk having a tabletop disposed atop a plurality of vertically adjustable legs. Each vertically adjustable leg has an adjustable length and causes the tabletop to be vertically lowered or raised. The microscope may be converted into an upright and inverted configuration and includes an objective for receiving light reflected from a specimen, a condenser for illuminating the specimen, and a stage for supporting the specimen. The microscope rests on a supporting surface disposed under the tabletop and is inserted through an opening on the tabletop.

公开(公告)号：US20180252648A1

公开(公告)日：2018-09-06

申请号：US15904499

申请日：2018-02-26

申请人： OLYMPUS CORPORATION

发明人： Masahito DOHI

IPC分类号： G01N21/64 ,  G02B21/00 ,  G02B21/10

CPC分类号： G01N21/6458 ,  G01N2021/6463 ,  G01N2021/6478 ,  G01N2201/06113 ,  G01N2201/0683 ,  G02B5/12 ,  G02B21/0032 ,  G02B21/0048 ,  G02B21/0068 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/0084 ,  G02B21/0088 ,  G02B21/10

摘要： In the present invention, cells cultured inside the wells of a microplate are observed easily and clearly regardless of the height or curvature state of the liquid surface of the culturing liquid. Provided is an observation device that includes an illumination optical system that irradiates a transparent sample with illumination light from a light source, an objective lens that collects observation light from the sample, a detection optical system that detects the observation light collected by the objective lens, and a retroreflective member that is arranged opposite the objective lens with the sample interposed therebetween and in which a plurality of very small reflective elements are arrayed. The objective lens and the illumination optical system are arranged below the sample in the direction of gravity.

公开(公告)号：US20180120551A1

公开(公告)日：2018-05-03

申请号：US15854884

申请日：2017-12-27

申请人： RIKEN

发明人： Yuichi TANIGUCHI ,  Kazuya NISHIMURA

IPC分类号： G02B21/16 ,  G02B21/33 ,  G02B21/26 ,  G02B21/08 ,  G02B21/24 ,  G02B21/00 ,  G01N21/64 ,  G02B21/10

CPC分类号： G02B21/16 ,  G01N21/6458 ,  G02B21/0076 ,  G02B21/0088 ,  G02B21/08 ,  G02B21/10 ,  G02B21/24 ,  G02B21/26 ,  G02B21/33

摘要： A microscope includes: a sample placement part having a placement surface on which to place a sample and a bottom face opposite to the placement surface; an observation lens; and an optical unit for generating sheet light and use of the microscope. The microscope of an embodiment is arranged such that the sheet light enters the sample placement part from the bottom face and passing through the sample placement part to irradiate the sample, and fluorescence from the sample passes through the sample placement part toward the bottom face to be received by the observation lens. The microscope can, with this arrangement, utilize the advantages of a SPIM, and allows observation of a sample which observation is free from a restriction of the size of a sample.

公开(公告)号：US09946057B2

公开(公告)日：2018-04-17

申请号：US14785624

申请日：2014-05-07

申请人： European Molecular Biology Laboratory

发明人： Lars Hufnagel ,  Jan Ellenberg ,  Uros Krzic ,  Petr Strnad

IPC分类号： G02B21/06 ,  G02B21/00 ,  G01N21/64 ,  G02B21/16 ,  G02B21/34 ,  G02B21/36 ,  G02B21/02 ,  G02B21/33

CPC分类号： G02B21/06 ,  G01N21/6458 ,  G02B21/0076 ,  G02B21/0088 ,  G02B21/02 ,  G02B21/16 ,  G02B21/33 ,  G02B21/34 ,  G02B21/367

摘要： A microscope module (300) for imaging a sample (270) is disclosed. The microscope module (300) includes at least one illumination objective (210) for producing an illumination beam along an illumination beam path (215) arranged to illuminate lower surface of the sample (270) and at least one detection objective (220) having a detection path (225). The detection path (225) is at an angle to the illumination beam path (215).

公开(公告)号：US20180073865A1

公开(公告)日：2018-03-15

申请号：US15815867

申请日：2017-11-17

申请人： OLYMPUS CORPORATION

发明人： Yoshimasa SUZUKI ,  Hisashi ODE ,  Mayumi ODAIRA

IPC分类号： G01B11/25 ,  G01B11/26 ,  G02B21/08

CPC分类号： G01B11/2513 ,  G01B11/24 ,  G01B11/26 ,  G02B21/0016 ,  G02B21/0088 ,  G02B21/082 ,  G02B21/084 ,  G02B21/26 ,  G02B21/364

摘要： A sample shape measuring method includes a step of preparing illumination light passing through a predetermined illumination region, a step of applying the illumination light to a sample, and a predetermined processing step. The predetermined illumination region is set so as not to include the optical axis at a pupil position of the illumination optical system and is set such that the illumination light is applied to part of the inside of the pupil and the outside of the pupil at a pupil position of the observation optical system. The predetermined processing step includes a step of receiving light, a step of obtaining the quantity of light, a step of calculating the difference or the ratio between the quantity of light and a reference quantity of light, and a step of calculating the amount of tilt in the surface of the sample from the difference or the ratio.

公开(公告)号：US09910256B2

公开(公告)日：2018-03-06

申请号：US15378494

申请日：2016-12-14

申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD.

发明人： Natan Tzvi Shaked ,  Pinhas Girshovitz

IPC分类号： G02B21/00 ,  G01B9/02

CPC分类号： G02B21/0056 ,  G01B9/02024 ,  G01B9/02032 ,  G01B9/02042 ,  G01B9/02049 ,  G01B9/02054 ,  G01B9/02057 ,  G01B9/02075 ,  G01B9/02097 ,  G01B9/04 ,  G01B11/06 ,  G01B2290/50 ,  G02B21/0008 ,  G02B21/0016 ,  G02B21/008 ,  G02B21/0088

摘要： The present invention provides a novel simple, portable, compact and inexpensive approach for interferometric optical thickness measurements that can be easily incorporated into an existing microscope (or other imaging systems) with existing cameras. According to the invention, the interferometric device provides a substantially stable, easy to align common path interferometric geometry, while eliminating a need for controllably changing the optical path of the beam. To this end, the inexpensive and easy to align interferometric device of the invention is configured such that it applies the principles of the interferometric measurements to a sample beam only, being a single input into the interferometric device.

公开(公告)号：US20170336615A1

公开(公告)日：2017-11-23

申请号：US15493800

申请日：2017-04-21

申请人： Yokogawa Electric Corporation

发明人： Tsuyoshi NAKAMURA

IPC分类号： G02B21/33 ,  G02B21/02 ,  G02B21/00

CPC分类号： G02B21/33 ,  G02B7/028 ,  G02B21/0088 ,  G02B21/02

摘要： An objective lens unit for a liquid immersion microscope includes: a first liquid passage in a pipe shape including an opening disposed at a lens surface end as a lens surface of a lens at a closest side to an observing object, the first liquid passage being coupled to an outside of the objective lens unit, and a second liquid passage in a pipe shape disposed independently from the first liquid passage, the second liquid passage including an opening disposed at a position adjacent to the opening of the first liquid passage on the lens surface end, the second liquid passage being coupled to the outside of the objective lens unit.

公开(公告)号：US09797816B2

公开(公告)日：2017-10-24

申请号：US14421506

申请日：2013-08-13

申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER

发明人： Sanjee Abeytunge ,  Ricardo Toledeo-Crow ,  Milind Rajadhyaksha

IPC分类号： G01N1/28

CPC分类号： G01N1/286 ,  G02B21/0088 ,  G02B21/34

摘要： Exemplary embodiments of apparatus and method for facilitating an analysis of a sample(s) can be provided. For example, using a first arrangement(s), it can be possible to receive the sample(s) thereon. Further, for example, using a second arrangement(s), it can be possible to cause a force to be applied on a portion(s) of the sample(s) such that a surface(s) of the sample(s) can be flattened against a section(s) of the first arrangement(s).

公开(公告)号：US20170090175A1

公开(公告)日：2017-03-30

申请号：US15270712

申请日：2016-09-20

申请人： OLYMPUS CORPORATION

发明人： Masaru KOBAYASHI

IPC分类号： G02B21/24 ,  G02B7/28 ,  G02B5/00

CPC分类号： G02B21/245 ,  G02B5/005 ,  G02B7/287 ,  G02B21/0088 ,  G02B21/02 ,  G02B21/082 ,  G02B27/141 ,  G02B27/283

摘要： A microscope apparatus includes an objective and an automatic focusing device. The automatic focusing device is an automatic focusing device of an active type that irradiates a specimen with automatic focusing light via the objective, and the automatic focusing device is configured in such away that an illumination light axis of the automatic focusing light passes through a position distant from an optical axis of the objective.