公开(公告)号：US10941179B2

公开(公告)日：2021-03-09

申请号：US16184028

申请日：2018-11-08

Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Yukako Senga ,  Hideki Watanabe ,  Shinya Honda

IPC: C07K1/22 ,  C07K16/00 ,  C07K1/14 ,  C07K1/02 ,  C07K14/00 ,  C07K7/06 ,  C07K7/08 ,  C07K1/32 ,  C07K16/06 ,  C07K1/36 ,  A61K39/395

Abstract: The present invention relates to a method for suppressing aggregation of polypeptide. Specifically, the present invention relates to a method for suppressing, in a solution comprising an antibody or an Fc region-containing protein, formation of an aggregate derived from an antibody or an Fc region-containing protein having a non-native conformation, the method comprising: the steps of (i) binding an AF.2A1 polypeptide or an analog thereof with an aggregate derived from the antibody or Fc region-containing protein having a non-native conformation in the solution; and (ii) collecting the aggregate bound to the polypeptide or analog thereof from the solution.

公开(公告)号：US20190135860A1

公开(公告)日：2019-05-09

申请号：US16184028

申请日：2018-11-08

Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Yukako Senga ,  Hideki Watanabe ,  Shinya Honda

IPC: C07K1/32 ,  C07K16/06 ,  C07K1/02 ,  C07K1/14 ,  C07K1/36

Abstract: The present invention relates to a method for suppressing aggregation of polypeptide. Specifically, the present invention relates to a method for suppressing, in a solution comprising an antibody or an Fc region-containing protein, formation of an aggregate derived from an antibody or an Fc region-containing protein having a non-native conformation, the method comprising: the steps of (i) binding an AF.2A1 polypeptide or an analog thereof with an aggregate derived from the antibody or Fc region-containing protein having a non-native conformation in the solution; and (ii) collecting the aggregate bound to the polypeptide or analog thereof from the solution.