公开(公告)号：US20240316250A1

公开(公告)日：2024-09-26

申请号：US18734282

申请日：2024-06-05

申请人： NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  SAPPORO MEDICAL UNIVERSITY ,  ADEKA CORPORATION ,  KM Biologics Co., Ltd.

发明人： Junichi MATSUDA ,  Sumika MIYABASHIRA ,  Satomi HARANO ,  Akio KISHIDA ,  Tsuyoshi KIMURA ,  Jun NEGISHI ,  Tetsuya HIGAMI ,  Seiichi FUNAMOTO ,  Ken-Ichiro HIWATARI ,  Akiko TASAKI

IPC分类号： A61L27/52 ,  A61K35/22 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/36 ,  A61K38/48 ,  A61L27/22 ,  A61L27/26 ,  A61L27/36 ,  A61L27/54 ,  C12N5/00

CPC分类号： A61L27/52 ,  A61K35/22 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/363 ,  A61K38/4833 ,  A61L27/225 ,  A61L27/26 ,  A61L27/3633 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/54 ,  C12N5/0068 ,  A61L2430/00 ,  A61L2430/20 ,  A61L2430/32 ,  C12N2533/50 ,  C12N2533/56 ,  C12N2533/90

摘要： A hybrid gel comprising a particulate decellularized tissue (obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues)), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel of the present invention exerts the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases.

公开(公告)号：US20180078679A1

公开(公告)日：2018-03-22

申请号：US15556776

申请日：2016-03-07

申请人： THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE ,  ADEKA CORPORATION ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  SAPPORO MEDICAL UNIVERSITY

发明人： Hideki SAGA ,  Takanori UCHIDA ,  Shoko TOKOROZAKI ,  Ken-ichiro HIWATARI ,  Haruki OBARA ,  Akio KISHIDA ,  Tsuyoshi KIMURA ,  Jun NEGISHI ,  Tetsuya HIGAMI ,  Seiichi FUNAMOTO

IPC分类号： A61L31/04

CPC分类号： A61L31/046 ,  A61L24/106 ,  A61L31/005 ,  A61L31/10 ,  A61L2300/424

摘要： An anti-adhesion material comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing an anti-adhesion material comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; an anti-adhesion material kit comprising decellularized tissues and a biocompatible polymer or fibrin glue; a substitute biomembrane comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing a substitute biomembrane comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; and a substitute biomembrane kit comprising decellularized tissues and a biocompatible polymer or fibrin glue.

公开(公告)号：US20160051731A1

公开(公告)日：2016-02-25

申请号：US14888871

申请日：2014-05-02

申请人： THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  SAPPORO MEDICAL UNIVERSITY ,  ADEKA CORPORATION

发明人： Junichi MATSUDA ,  Sumika MIYABASHIRA ,  Satomi HARANO ,  Akio KISHIDA ,  Tsuyoshi KIMURA ,  Jun NEGISHI ,  Tetsuya HIGAMI ,  Seiichi FUNAMOTO ,  Ken-ichiro HIWATARI ,  Akiko TASAKI

IPC分类号： A61L27/52 ,  A61L27/22 ,  A61L27/26 ,  C12N5/00 ,  A61L27/36

CPC分类号： A61L27/52 ,  A61K35/22 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/363 ,  A61K38/4833 ,  A61L27/225 ,  A61L27/26 ,  A61L27/3633 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/54 ,  A61L2430/00 ,  A61L2430/20 ,  A61L2430/32 ,  C12N5/0068 ,  C12N2533/50 ,  C12N2533/56 ,  C12N2533/90

摘要： A hybrid gel comprising a particulate decellularized tissue (obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues)), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel of the present invention exerts the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases.

摘要翻译： 一种混合凝胶，其包含颗粒脱细胞组织（通过粉碎去细胞化的（来自脱细胞的生物组织）的动物衍生的生物组织），纤维蛋白原和凝血酶获得; 包含所述杂交凝胶的细胞培养物质; 制备混合凝胶的方法; 并提供了包含颗粒脱细胞组织和生物组织粘合剂的试剂盒。 本发明的混合凝胶发挥促进干细胞分化和增殖功能的效果以及对各种疾病的治疗效果。

公开(公告)号：US20160058910A1

公开(公告)日：2016-03-03

申请号：US14783232

申请日：2014-05-02

申请人： NATIIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  ADEKA CORPORATION

发明人： Akio KISHIDA ,  Tsuyoshi KIMURA ,  Jun NEGISHI ,  Ken-ichiro HIWATARI ,  Akiko TASAKI

IPC分类号： A61L27/36 ,  A61L27/54 ,  A61L27/58 ,  C12N5/00

摘要： A particulate decellularized tissue is provided which shows sufficiently effective tissue regeneration and does not show cytotoxicity when used as material for cell culture. In accordance with the method for preparing a particulate decellularized tissue comprising a step of applying a high hydrostatic pressure to animal-derived tissues in a medium, a particulate decellularized tissue is obtained which does not show cytotoxicity but shows the effect of cellular attraction and the effect of induction of cellular differentiation and shows a high effect of tissue regeneration.

摘要翻译： 提供了一种颗粒脱细胞组织，其显示出足够有效的组织再生，并且当用作细胞培养的材料时不显示细胞毒性。 根据制备颗粒脱细胞组织的方法，包括将高静水压力施加到培养基中的动物衍生组织的步骤，获得不显示细胞毒性但显示细胞吸引作用的效果的颗粒脱细胞组织 的细胞分化诱导，并显示组织再生的高效果。