公开(公告)号：US11291680B2

公开(公告)日：2022-04-05

申请号：US15839359

申请日：2017-12-12

Applicant: NESTEC SA

Inventor： Rondo P Middleton ,  Brian M Zanghi ,  Serge Andre Dominique Rezzi ,  Steven S Hannah

IPC: A23K20/147 ,  A23K20/158 ,  A61K31/198 ,  A61K31/405 ,  A61K31/7056 ,  A23K10/00 ,  A23K20/00 ,  A23K20/10 ,  A23K20/163 ,  A23K50/42 ,  A23K50/48 ,  A61K31/194 ,  A61K31/197 ,  A61K31/225 ,  A61K31/23 ,  A61K31/235 ,  A61K31/255 ,  A61K31/683 ,  A61K31/7072 ,  G01N33/50

Abstract: White blood cells and/or neutrophils in a companion animal can be improved by adjusting the diet of the animal to increase the amount of a compound which positively or negatively modulates the white blood cells and/or neutrophils or adjusting the diet of the animal to decrease the amount of a compound which positively or negatively modulates the white blood cells and/or neutrophils.

公开(公告)号：US20180169127A1

公开(公告)日：2018-06-21

申请号：US15839359

申请日：2017-12-12

Applicant: NESTEC SA

Inventor： Rondo P. Middleton ,  Brian M. Zanghi ,  Serge Andre Dominique Rezzi ,  Steven S. Hannah

IPC: A61K31/7056 ,  A61K31/194 ,  A61K31/198 ,  A61K31/23 ,  A61K31/7072 ,  A61K31/197 ,  A61K31/683 ,  A61K31/235 ,  A61K31/225 ,  A61K31/255 ,  A61K31/405 ,  G01N33/50 ,  A23K20/147 ,  A23K20/158 ,  A23K20/163 ,  A23K50/42 ,  A23K50/48

Abstract: White blood cells and/or neutrophils in a companion animal can be improved by adjusting the diet of the animal to increase the amount of a compound which positively or negatively modulates the white blood cells and/or neutrophils or adjusting the diet of the animal to decrease the amount of a compound which positively or negatively modulates the white blood cells and/or neutrophils.

公开(公告)号：US11758928B2

公开(公告)日：2023-09-19

申请号：US15839347

申请日：2017-12-12

Applicant: NESTEC SA

Inventor： Rondo P Middleton ,  Brian M Zanghi ,  Serge Andre Dominique Rezzi ,  Steven S Hannah

IPC: A23K50/40 ,  A23K20/153 ,  A23K10/00 ,  A23K20/142 ,  A23K20/147 ,  A23K20/158 ,  A23K20/163 ,  A61P7/00 ,  A61P21/00 ,  A61P1/16 ,  A61P9/00 ,  A61P1/18 ,  A61P1/12 ,  A61P13/12 ,  A61P1/00 ,  A61P5/00 ,  A61P19/08 ,  A61P25/00 ,  A61K31/047 ,  A61K31/17 ,  A61K31/185 ,  A61K31/19 ,  A61K31/191 ,  A61K31/194 ,  A61K31/197 ,  A61K31/198 ,  A61K31/205 ,  A61K31/405 ,  A61K31/4166 ,  A61K31/4425 ,  A61K31/513 ,  A61K31/575 ,  A61K31/661 ,  A61K31/7004 ,  A61K31/7068 ,  A61K33/42 ,  A61K38/07

CPC classification number: A23K50/40 ,  A23K10/00 ,  A23K20/142 ,  A23K20/147 ,  A23K20/153 ,  A23K20/158 ,  A23K20/163 ,  A61K31/047 ,  A61K31/17 ,  A61K31/185 ,  A61K31/19 ,  A61K31/191 ,  A61K31/194 ,  A61K31/197 ,  A61K31/198 ,  A61K31/205 ,  A61K31/405 ,  A61K31/4166 ,  A61K31/4425 ,  A61K31/513 ,  A61K31/575 ,  A61K31/661 ,  A61K31/7004 ,  A61K31/7068 ,  A61K33/42 ,  A61K38/07 ,  A61P1/00 ,  A61P1/12 ,  A61P1/16 ,  A61P1/18 ,  A61P5/00 ,  A61P7/00 ,  A61P9/00 ,  A61P13/12 ,  A61P19/08 ,  A61P21/00 ,  A61P25/00

Abstract: A specific type of organ health marker in a companion animal can be improved by adjusting the diet of the animal to increase the amount of a compound which positively or negatively modulates the specific type of organ health marker or adjusting the diet of the animal to decrease the amount of a compound which positively or negatively modulates the specific type of organ health marker. The specific type of organ health marker can be one or more of phosphorus, alkaline phosphatase, aspartate aminotransferase, or gamma-glutamyltransferase.

公开(公告)号：US20180169068A1

公开(公告)日：2018-06-21

申请号：US15839333

申请日：2017-12-12

Applicant: NESTEC SA

Inventor： Rondo P. Middleton ,  Brian M. Zanghi ,  Serge Andre Dominique Rezzi ,  Steven S. Hannah

IPC: A61K31/4015 ,  A61K31/198 ,  A61K31/4168 ,  A61K38/05 ,  A61K31/401 ,  A61K31/522 ,  A61K31/05 ,  A61K31/047 ,  A61K31/133 ,  A61K31/7068 ,  A61K31/197 ,  A61K31/202 ,  A61K31/192 ,  A61K31/7004 ,  A61K31/216 ,  A61K31/405 ,  A61K31/404 ,  A61P19/10 ,  A61P19/08 ,  A61P25/00 ,  A61P37/00 ,  A61P9/00 ,  A61P3/10 ,  A61P35/00 ,  A61P35/02 ,  A61P17/00 ,  A61P19/00 ,  A61K9/00 ,  A23K20/174 ,  A23K20/147 ,  A23K20/158 ,  A23K20/163 ,  A23K50/40

Abstract: Bone mineral content, 25(OH) vitamin D3, or 1,25(OH)2 vitamin D3 in a companion animal can be improved by adjusting the diet of the animal to increase the amount of a compound which positively or negatively modulates the bone mineral content, 25(OH) vitamin D3, or 1,25(OH)2 vitamin D3 or adjusting the diet of the animal to decrease the amount of a compound which positively or negatively modulates the bone mineral content, 25(OH) vitamin D3, or 1,25(OH)2 vitamin D3.

公开(公告)号：US20180168197A1

公开(公告)日：2018-06-21

申请号：US15839393

申请日：2017-12-12

Applicant: NESTEC SA

Inventor： Rondo P Middleton ,  Brian M. Zanghi ,  Serge Andre Dominique Rezzi ,  Steven S. Hannah

IPC: A23K50/40 ,  A23K20/142 ,  A23K20/147 ,  A23K20/158 ,  A23K20/163 ,  A23K20/174 ,  A23K10/20 ,  A23K10/30

Abstract: A specific type of digestibility in a companion animal can be improved by adjusting the diet of the animal to increase the amount of a compound which positively or negatively modulates the specific type of digestibility or adjusting the diet of the animal to decrease the amount of a compound which positively or negatively modulates the specific type of digestibility. The specific type of digestibility can be one or more of organic matter digestibility, dry matter digestibility, fiber digestibility, energy digestibility, fat digestibility, or protein digestibility.

公开(公告)号：US20180168195A1

公开(公告)日：2018-06-21

申请号：US15839370

申请日：2017-12-12

Applicant: NESTEC SA

Inventor： Rondo P. Middleton ,  Brain M. Zanghi ,  Serge Andre Dominique Rezzi ,  Steven S. Hannah

IPC: A23K50/40 ,  A61K31/661 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P29/00 ,  A61K31/191 ,  A61K31/355 ,  A61K31/575 ,  A61K31/7068 ,  A61K31/19 ,  A61K31/16 ,  A61K31/194 ,  A61K31/708 ,  A61K31/20 ,  A61K31/202 ,  A23K20/142 ,  A23K20/147 ,  A23K20/158 ,  A23K20/163

Abstract: Cholesterol, high-density lipoproteins, and low-density lipoproteins in a companion animal can be improved by adjusting the diet of the animal to increase the amount of a compound which positively or negatively modulates the cholesterol, high-density lipoproteins, or low-density lipoproteins or adjusting the diet of the animal to decrease the amount of a compound which positively or negatively modulates cholesterol, high-density lipoproteins, or low-density lipoproteins.

公开(公告)号：US20180168196A1

公开(公告)日：2018-06-21

申请号：US15839384

申请日：2017-12-12

Applicant: NESTEC SA

Inventor： Rondo P. Middleton ,  Brian M. Zanghi ,  Serge Andre Dominique Rezzi ,  Steven S. Hannah

IPC: A23K50/40 ,  A61K31/575 ,  A61K31/192 ,  A61K31/197 ,  A61K31/20 ,  A61K31/047 ,  A61K31/405 ,  A61K31/202 ,  A61K31/7004 ,  A61K31/4418 ,  A61K31/198 ,  A61P1/14 ,  A61P1/00 ,  A61P17/00 ,  A61P31/00 ,  A61P37/00 ,  A23K20/142 ,  A23K20/147 ,  A23K20/163 ,  A23K20/158

Abstract: A specific bacterium in a companion animal can be improved by adjusting the diet of the animal to increase the amount of a compound which positively or negatively modulates the specific type of bacterium or to decrease the amount of a compound which positively or negatively modulates the specific type of bacterium. The specific type of bacterium can be one or more of Bifidobacterium, Lactobacillus, or Clostridium perfringens.

公开(公告)号：US20140073526A1

公开(公告)日：2014-03-13

申请号：US14021495

申请日：2013-09-09

Applicant: Nestec SA

Inventor： Rondo Paul Middleton ,  Ziad S. Ramadan ,  Serge Andre Dominique Rezzi ,  Sebastiano Collino ,  Francois-Pierre Martin

IPC: C12Q1/68 ,  G01N33/68

CPC classification number: C12Q1/6883 ,  C12Q2600/158 ,  G01N33/5088 ,  G01N33/68 ,  G01N33/6863 ,  G01N2800/7042

Abstract: The invention provides biomarkers associated with age related immune function and the use of the biomarkers to identify compositions useful for strengthening immune function in animals and to determine if an animal is responding to treatment targeted to strengthen the immune system.

Abstract translation: 本发明提供与年龄相关的免疫功能相关的生物标志物，以及使用生物标志物来鉴定用于增强动物免疫功能的组合物，并确定动物是否对靶向治疗作出反应以加强免疫系统。

公开(公告)号：US20180168194A1

公开(公告)日：2018-06-21

申请号：US15839347

申请日：2017-12-12

Applicant: NESTEC SA

Inventor： Rondo P. Middleton ,  Brian M. Zanghi ,  Serge Andre Dominique Rezzi ,  Steven S. Hannah

IPC: A23K50/40 ,  A61K33/42 ,  A61K38/07 ,  A61K31/198 ,  A61K31/205 ,  A61K31/047 ,  A61K31/17 ,  A61K31/19 ,  A61K31/7004 ,  A61K31/405 ,  A61K31/513 ,  A61K31/191 ,  A61K31/197 ,  A61K31/185 ,  A61K31/661 ,  A61K31/4166 ,  A61K31/7068 ,  A61K31/4425 ,  A61K31/575 ,  A61K31/194 ,  A61P1/16 ,  A61P13/12 ,  A61P19/08 ,  A61P5/00 ,  A61P1/00 ,  A61P1/18 ,  A61P9/00 ,  A61P21/00 ,  A61P7/00 ,  A61P25/00 ,  A61P1/12 ,  A23K20/142 ,  A23K20/147 ,  A23K20/163 ,  A23K20/158

Abstract: A specific type of organ health marker in a companion animal can be improved by adjusting the diet of the animal to increase the amount of a compound which positively or negatively modulates the specific type of organ health marker or adjusting the diet of the animal to decrease the amount of a compound which positively or negatively modulates the specific type of organ health marker. The specific type of organ health marker can be one or more of phosphorus, alkaline phosphatase, aspartate aminotransferase, or gamma-glutamyltransferase.