公开(公告)号：US20190120742A1

公开(公告)日：2019-04-25

申请号：US16169119

申请日：2018-10-24

申请人： NIHON KOHDEN CORPORATION ,  TOKYO WOMEN'S MEDICAL UNIVERSITY

发明人： Hirotsugu KUBO ,  Takahiro SHIOYAMA ,  Yuki KAGAWA ,  Tatsuya SHIMIZU ,  Daisuke SASAKI

IPC分类号： G01N13/02 ,  A61B5/00 ,  C12N5/077

摘要： A device for measuring a tension of a sheet-like tissue containing cardiomyocytes includes a first gel adapter holder having a frame member and a first gel holding member protruding toward a part of an inside face of the frame member for fixing one end of a film-like gel; and a second gel adapter holder having a second gel holding member for fixing the other end of the gel and a connection member connected to the second gel holding member. A kit includes the tension measuring device; a substrate having a pair of gel molding protruding members fitted along the inside face of the frame member; and a gel forming lid body having a face parallel to a gel contact face of the substrate so as to form an upper face of the gel. Further, a system for measuring the tension includes the tension measuring device.

公开(公告)号：US20240008859A1

公开(公告)日：2024-01-11

申请号：US18039171

申请日：2021-11-29

申请人： NIHON KOHDEN CORPORATION ,  NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM ,  UNIVERSITY PUBLIC CORPORATION OSAKA

发明人： Shinya NAGATA ,  Akane SUZUKI ,  Takahiro SHIOYAMA ,  Tadanori SUGIMOTO ,  Yukino SHINOZAKI ,  Masakazu SATSU ,  Chikara OHTSUKI ,  Jin NAKAMURA ,  Hideo AKIYOSHI ,  Hidetaka NISHIDA ,  Keiichiro MIE

IPC分类号： A61B10/02 ,  A61F2/01 ,  A61L31/02 ,  A61L31/12 ,  A61L31/14

CPC分类号： A61B10/02 ,  A61F2/01 ,  A61L31/026 ,  A61L31/124 ,  A61L31/146

摘要： Provided is a porous body for capturing cancer cells, including a biocompatible inorganic material, the porous body for capturing cancer cells having biocompatibility and also having stability in a living body. The porous body for capturing cancer cells can be used for application related to cancer such as a treatment, a treatment assistance, a test, or a diagnosis.

公开(公告)号：US20150078649A1

公开(公告)日：2015-03-19

申请号：US14488947

申请日：2014-09-17

申请人： Nihon Kohden Corporation

发明人： Sunao TAKEDA ,  Hirotsugu KUBO ,  Takahiro SHIOYAMA ,  Akane SUZUKI ,  Kenichi NOMURA ,  Yo KATO ,  Nae HINATA

IPC分类号： G06K9/00 ,  G01N15/14 ,  G01N21/64

CPC分类号： G06K9/00127 ,  A61B5/0071 ,  G01N15/1429 ,  G01N15/1459 ,  G01N21/6428 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1486 ,  G01N2015/1488 ,  G01N2021/6439

摘要： A cell analyzing apparatus includes: a first histogram acquiring section which is configured to acquire a first histogram of fluorescence intensities by using a result of a measurement of a number of nuclear stained cells; a second histogram acquiring section which is configured to acquire a second histogram that is normalized based on a fluorescence intensity value indicating a maximum value of the first histogram; a determining section which is configured to determine whether cancer cells exist or not, based on one of the first histogram and the second histogram; and an outputting section which is configured to output a result of the determination performed by the determining section.

摘要翻译： 细胞分析装置包括：第一直方图获取部，其被配置为通过使用核染色细胞的数量的测量结果来获取荧光强度的第一直方图; 第二直方图获取部，其被配置为获取基于指示所述第一直方图的最大值的荧光强度值被归一化的第二直方图; 基于第一直方图和第二直方图之一，被配置为确定是否存在癌细胞的确定部分; 以及输出部，其被配置为输出由所述确定部执行的所述确定的结果。

公开(公告)号：US20130330248A1

公开(公告)日：2013-12-12

申请号：US13904398

申请日：2013-05-29

申请人： NIHON KOHDEN CORPORATION

发明人： Takahiro SHIOYAMA ,  Akane SUZUKI ,  Hirotsugu KUBO

IPC分类号： B01L3/02

CPC分类号： B01L3/021 ,  C12M45/02 ,  C12M47/08

摘要： A cell isolation apparatus in which tissue and fluid that are accommodated in a container are pipetted by a pipette, and cells are isolated from the tissue, the cell isolation apparatus includes: a nozzle to which the pipette is attached; a pump which is connected to the nozzle; a controller which is configured to control an operation of the pump to cause air to be ejected from the nozzle or to be sucked into the nozzle, thereby causing the pipette to perform pipetting; and a condition inputting unit in which a user inputs a condition of control of the controller.

摘要翻译： 一种细胞分离装置，其中容纳在容器中的组织和流体由移液管吸移，并且细胞与组织分离，细胞分离装置包括：吸附器附着的喷嘴; 连接到喷嘴的泵; 控制器，其被配置为控制所述泵的操作以使空气从所述喷嘴喷射或被吸入所述喷嘴，从而使所述移液管进行吸移; 以及条件输入单元，其中用户输入控制器的控制条件。

公开(公告)号：US20220002677A1

公开(公告)日：2022-01-06

申请号：US17366771

申请日：2021-07-02

申请人： NIHON KOHDEN CORPORATION

发明人： Hirotsugu KUBO ,  Takahiro SHIOYAMA ,  Yuki KAGAWA ,  Yuto HINATA ,  Tatsuya SHIMIZU ,  Daisuke SASAKI ,  Yuji HARAGUCHI

IPC分类号： C12N5/077

摘要： A transfer method includes a centrifugation step for applying centrifugal force in the direction of lamination to a laminate of a cell structure disposed on a temperature-responsive culture dish and a gel placed on the cell structure and a peeling step for maintaining the temperature at the lower critical solution temperature of the temperature-responsive culture dish or lower and peeling off the cell structure containing muscle cells from the temperature-responsive culture dish.