公开(公告)号：US20210188894A1

公开(公告)日：2021-06-24

申请号：US16077969

申请日：2017-02-17

Applicant: TOKYO INSTITUTE OF TECHNOLOGY ,  NISSAN CHEMICAL CORPORATION

Inventor： Kohji SEIO ,  Yoshiaki MASAKI ,  Keishi YAMAMOTO ,  Keita YOSHIDA ,  Yusuke IRIYAMA ,  Hiroyuki NAKAJIMA ,  Tatsuro KANAKI

IPC: C07H21/02 ,  C07H19/067

Abstract: Provided is an artificial nucleoside or artificial nucleotide capable of composing an artificial oligonucleotide having superior nuclease resistance. The artificial nucleoside or artificial nucleotide is a compound represented by formula (I) or a salt thereof (wherein, Bx represents a pyrimidine base or purine base, R1, R2, R3 and R4 represent hydrogen atoms, C1-6 alkyl groups or the like, Y represents NR5R6 (wherein, R5 and R6, independently of each other, represent a hydrogen atom, C1-6 alkyl group or the like, or R5 and R6, together with a nitrogen atom bound thereto, form a 3- to 11-membered nitrogen-containing non-aromatic heterocyclic group) or an optionally substituted C2-9 aromatic heterocyclic group, Z1 and Z2 represent hydrogen atoms, hydroxyl group-protecting groups, phosphorous-containing groups or the like, and n represents an integer of 1 to 3).

公开(公告)号：US20200224196A1

公开(公告)日：2020-07-16

申请号：US16633532

申请日：2018-07-26

Applicant: NISSAN CHEMICAL CORPORATION

Inventor： Yusuke IRIYAMA ,  Hiroyuki NAKAJIMA ,  Tatsuro KANAKI

IPC: C12N15/113 ,  A61K31/712 ,  C12N15/10

Abstract: The invention provides a single-stranded oligonucleotide represented by the formula [Xz-Lx]m-X-Y-[Ly-Yz]n, wherein X is represented by Xa-Xb, Xa is coupled with Y, and Xb and Y hybridize. Xa is composed of 1 to 40 nucleotides and contains at least one modified-nucleotide. Xb is composed of 4 to 40 nucleotides and contains at least one modified-nucleotide. Y is composed of 4 to 40 nucleotides and contains at least one ribonucleotide. Xz and Yz are composed of 5 to 40 nucleotides and contain at least one modified-nucleotide. Nucleotide sequences X, Xz and Yz have an antisense sequence capable of hybridizing with a target RNA. Lx and Ly are composed of 0 to 20 nucleotides.

公开(公告)号：US20210253518A1

公开(公告)日：2021-08-19

申请号：US16973337

申请日：2019-06-06

Applicant: NISSAN CHEMICAL CORPORATION

Inventor： Taito NISHINO ,  Keiichiro OTSUKA ,  Natsuki FUKASAWA ,  Hiroyuki NAKAJIMA ,  Ayako AIHARA

IPC: C07C281/14 ,  C07C251/86

Abstract: The present invention aims to provide a novel kinase inhibitor and the like, and a therapeutic agent for a disease, a drug discovery screening method and the like utilizing such inhibitor and the like. The compound represented by the following formula (I) and a salt thereof can inhibit plural kinases including LATS (particularly LATS2) which is the major kinase in the Hippo signal transduction pathway. In addition, diseases or tissue damage associated with failure of cellular proliferation can be treated. Therefore, the present invention is beneficial, for example, in the research field of cell functions and diseases, in which the Hippo signal transduction pathway is involved, and the like. Furthermore, it is beneficial in the medical field for the treatment of such diseases and the like. wherein each symbol is as defined in the DESCRIPTION.

公开(公告)号：US20230203498A1

公开(公告)日：2023-06-29

申请号：US18054660

申请日：2022-11-11

Applicant: NISSAN CHEMICAL CORPORATION

Inventor： Yusuke IRIYAMA ,  Hiroyuki NAKAJIMA ,  Tatsuro KANAKI

IPC: C12N15/113 ,  A61K48/00 ,  A61K31/7088 ,  C12P19/34

CPC classification number: C12N15/1137 ,  C12N15/113 ,  A61K48/00 ,  A61K31/7088 ,  C12P19/34 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/351 ,  C12N2310/3513 ,  C12N2310/3515

Abstract: Provided is a single-stranded oligonucleotide that is capable of controlling a target gene with high efficiency and can be easily produced. The single-stranded oligonucleotide is represented by the formula X-L-Y wherein X and Y hybridize by a first nucleotide sequence portion and a second nucleotide sequence portion. X is composed of 7 to 100 nucleotides, contains at least one modified nucleotide, and has a first nucleotide sequence that is capable of hybridizing with a second oligonucleotide and contains at least four contiguous nucleotides recognized by RNase H. Y is composed of 4 to 100 nucleotides, and has a second nucleotide sequence that is capable of hybridizing with a second oligonucleotide and contains at least one ribonucleotide. At least one of nucleotide sequence X and nucleotide sequence Y has an antisense sequence capable of hybridizing with a target RNA. L is a group derived from a third oligonucleotide that is degraded under physiological conditions.

公开(公告)号：US20230183702A1

公开(公告)日：2023-06-15

申请号：US18152504

申请日：2023-01-10

Applicant: NISSAN CHEMICAL CORPORATION

Inventor： Yusuke IRIYAMA ,  Hiroyuki NAKAJIMA ,  Tatsuro KANAKI

IPC: C12N15/113 ,  C12N15/10 ,  A61K31/712

CPC classification number: C12N15/113 ,  A61K31/712 ,  C12N15/1024

Abstract: The invention provides a single-stranded oligonucleotide represented by the formula [Xz — Lx]m — X — Y — [Ly — Yz]n, wherein X is represented by Xa-Xb, Xa is coupled with Y, and Xb and Y hybridize. Xa is composed of 1 to 40 nucleotides and contains at least one modified-nucleotide. Xb is composed of 4 to 40 nucleotides and contains at least one modified-nucleotide. Y is composed of 4 to 40 nucleotides and contains at least one ribonucleotide. Xz and Yz are composed of 5 to 40 nucleotides and contain at least one modified-nucleotide. Nucleotide sequences X, Xz and Yz have an antisense sequence capable of hybridizing with a target RNA. Lx and Ly are composed of 0 to 20 nucleotides.

公开(公告)号：US20220026440A1

公开(公告)日：2022-01-27

申请号：US17293996

申请日：2019-11-13

Applicant: NISSAN CHEMICAL CORPORATION

Inventor： Keiichiro OTSUKA ,  Satoshi HAMADA ,  Takeaki SHOJI ,  Kei NAGAE ,  Hiroyuki NAKAJIMA ,  Kohei SUZUKI ,  Kazutaka MATOBA

IPC: G01N33/68 ,  C08L101/02 ,  H01J49/00 ,  C12Q1/00 ,  B01L3/00

Abstract: The invention provides a container for storing a biomaterial in which adhesion of a minute amount of a biomarker(s) contained in the biomaterial to the surface of the container for storage can be suppressed, and sample loss is reduced, while enabling analysis with accuracy and highly precision. In particular, the container for storing a biomaterial for reducing sample loss of a biomarker(s) contained in the biomaterial has a coating containing a copolymer which contains a recurring unit which contains a group represented by the following formula (a), a recurring unit which contains a group represented by the following formula (b), and optionally a recurring unit which contains a group represented by the following formula (c), on at least a part of the surface of the container: (wherein, Ua1, Ua2, Ub1, Ub2 and Ub3, An− and Rc are as defined herein).

公开(公告)号：US20210171890A1

公开(公告)日：2021-06-10

申请号：US16762694

申请日：2018-11-08

Applicant: NISSAN CHEMICAL CORPORATION

Inventor： Hiroyuki NAKAJIMA ,  Taito NISHINO ,  Yoshiomi HIROI ,  Kohei SUZUKI

IPC: C12M1/00 ,  C09D185/02 ,  C09D201/06

Abstract: The invention provides a cell culture vessel with a coating which inhibits adhesion of a peptide relating to cell proliferation on at least a part of the surface thereof. The coating desirably contains a copolymer containing a recurring unit which contains a group represented by formula (a) and a recurring unit which contains a group represented by formula (b). wherein Ua1, Ua2, Ua3, Ub1, Ub2, Ub3 and An− are as defined herein.

公开(公告)号：US20190119683A1

公开(公告)日：2019-04-25

申请号：US16073114

申请日：2017-01-26

Applicant: NISSAN CHEMICAL CORPORATION

Inventor： Yusuke IRIYAMA ,  Hiroyuki NAKAJIMA ,  Tatsuro KANAKI

IPC: C12N15/113

Abstract: Provided is a single-stranded oligonucleotide that is capable of controlling a target gene with high efficiency and can be easily produced. The single-stranded oligonucleotide is represented by the formula X-L-Y wherein X and Y hybridize by a first nucleotide sequence portion and a second nucleotide sequence portion. X is composed of 7 to 100 nucleotides, contains at least one modified nucleotide, and has a first nucleotide sequence that is capable of hybridizing with a second oligonucleotide and contains at least four contiguous nucleotides recognized by RNase H. Y is composed of 4 to 100 nucleotides, and has a second nucleotide sequence that is capable of hybridizing with a second oligonucleotide and contains at least one ribonucleotide. At least one of nucleotide sequence X and nucleotide sequence Y has an antisense sequence capable of hybridizing with a target RNA. L is a group derived from a third oligonucleotide that is degraded under physiological conditions.

公开(公告)号：US20240084296A1

公开(公告)日：2024-03-14

申请号：US18162942

申请日：2023-02-01

Applicant: NISSAN CHEMICAL CORPORATION

Inventor： Yusuke IRIYAMA ,  Hiroyuki NAKAJIMA ,  Tatsuro KANAKI ,  Masatoshi NIWA

IPC: C12N15/113 ,  A61K31/7088

CPC classification number: C12N15/113 ,  A61K31/7088 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/3519 ,  C12N2310/531

Abstract: The invention provides a single-stranded oligonucleotide represented by the formula (I), wherein X and Y hybridize by a first nucleotide sequence portion and a second nucleotide sequence portion. X is composed of 7 to 100 nucleotides, contains at least one modified-nucleotide, and has a first nucleotide sequence capable of hybridizing with a second oligonucleotide. Y is composed of 4 to 100 nucleotides, enables hybridization with the above-mentioned first oligonucleotide, and has a second nucleotide sequence containing at least one ribonucleotide. At least one of the nucleotide sequences X, Xz and Y has an antisense sequence capable of hybridizing with a target RNA. At least one of L, Lx and Ly is a linking group that contains a non-nucleotide structure.

公开(公告)号：US20230235141A1

公开(公告)日：2023-07-27

申请号：US18002366

申请日：2021-06-18

Applicant: NISSAN CHEMICAL CORPORATION

Inventor： Yoshiomi HIROI ,  Hiroyuki NAKAJIMA ,  Taito NISHINO ,  Miya HIROI ,  Yuki UEDA

IPC: C08J7/04 ,  C09D7/20 ,  C09D133/10 ,  C09D179/08

CPC classification number: C08J7/04 ,  C09D7/20 ,  C09D133/10 ,  C09D179/08 ,  C08J2333/10 ,  C08J2379/08

Abstract: The invention provides a composition for forming a coating film containing a phosphoric acid group-containing polymer capable of forming a film on a substrate by a simple process and capable of maintaining film properties under a solvent environment containing water, and a coating film which is a cured product of the composition. In particular, the composition for forming a coating film contains (a) a polymer (P) containing a hydroxyl group, and the hydroxyl group is derived only from a phosphoric acid group, (b) a polycarbodiimide (C) containing a structure represented by the following formula (c-1):


—N═C═N—  (c-1),

and (c) a solvent.