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    CELL CULTURE CONTAINER CAPABLE OF CONTROLLING CELL AGGREGATION RATE
    1.
    发明申请
    CELL CULTURE CONTAINER CAPABLE OF CONTROLLING CELL AGGREGATION RATE 有权

    公开(公告)号：US20230093822A1

    公开(公告)日：2023-03-30

    申请号：US17904647

    申请日：2021-02-19

    申请人： NISSAN CHEMICAL CORPORATION

    发明人： Kohei SUZUKI ,  Natsuki FUKASAWA

    IPC分类号： C12N5/00

    摘要： The invention provides a substrate for producing cell aggregates provided with a spot(s) comprising a copolymer containing recurring units derived from monomers represented by the following formulae (I) and (II): wherein Ua1, Ua2, Ra1, Ra2 and Rb are as defined herein, on a substrate having an ability to inhibit adhesion of cells, wherein a completion time of forming cell aggregates after seeding cells is within 20 hours.

    METHOD FOR PRODUCING CELL AGGREGATES
    2.
    发明申请
    METHOD FOR PRODUCING CELL AGGREGATES 有权

    公开(公告)号：US20230116517A1

    公开(公告)日：2023-04-13

    申请号：US17904628

    申请日：2021-02-19

    申请人： NISSAN CHEMICAL CORPORATION ,  KAKE EDUCATIONAL INSTITUTION

    发明人： Kohei SUZUKI ,  Yoshiomi HIROI ,  Ryosuke IWAI

    IPC分类号： C12N11/087 ,  C08F220/36 ,  C09D11/36 ,  C09D11/107 ,  C09D133/14

    摘要： A substrate for producing cell aggregates provided with a plurality of spots which comprises a polymer containing a recurring unit derived from a monomer represented by the following formula (I): wherein Ua1, Ua2, Ra1 and Ra2 are as defined herein, on a substrate having an ability to inhibit adhesion of cells, wherein a ratio of a total area of the spots to a surface area of the substrate is 30% or more, a diameter of each spot is 50 to 5,000 μm, and a distance between the spots is 30 to 1,000 μm, a method for producing the same, and a method for producing cell aggregates using such a substrate and a method of improving cell utilization efficiency at the time of producing the cell aggregates.

    CONTAINER AND METHOD FOR STORING, PRETREATING, AND ANALYZING BIOMATERIAL
    5.
    发明申请
    CONTAINER AND METHOD FOR STORING, PRETREATING, AND ANALYZING BIOMATERIAL 有权

    公开(公告)号：US20220026440A1

    公开(公告)日：2022-01-27

    申请号：US17293996

    申请日：2019-11-13

    申请人： NISSAN CHEMICAL CORPORATION

    发明人： Keiichiro OTSUKA ,  Satoshi HAMADA ,  Takeaki SHOJI ,  Kei NAGAE ,  Hiroyuki NAKAJIMA ,  Kohei SUZUKI ,  Kazutaka MATOBA

    IPC分类号： G01N33/68 ,  C08L101/02 ,  H01J49/00 ,  C12Q1/00 ,  B01L3/00

    摘要： The invention provides a container for storing a biomaterial in which adhesion of a minute amount of a biomarker(s) contained in the biomaterial to the surface of the container for storage can be suppressed, and sample loss is reduced, while enabling analysis with accuracy and highly precision. In particular, the container for storing a biomaterial for reducing sample loss of a biomarker(s) contained in the biomaterial has a coating containing a copolymer which contains a recurring unit which contains a group represented by the following formula (a), a recurring unit which contains a group represented by the following formula (b), and optionally a recurring unit which contains a group represented by the following formula (c), on at least a part of the surface of the container: (wherein, Ua1, Ua2, Ub1, Ub2 and Ub3, An− and Rc are as defined herein).

    CELL CULTURE VESSEL
    6.
    发明申请
    CELL CULTURE VESSEL 有权

    公开(公告)号：US20210171890A1

    公开(公告)日：2021-06-10

    申请号：US16762694

    申请日：2018-11-08

    申请人： NISSAN CHEMICAL CORPORATION

    发明人： Hiroyuki NAKAJIMA ,  Taito NISHINO ,  Yoshiomi HIROI ,  Kohei SUZUKI

    IPC分类号： C12M1/00 ,  C09D185/02 ,  C09D201/06

    摘要： The invention provides a cell culture vessel with a coating which inhibits adhesion of a peptide relating to cell proliferation on at least a part of the surface thereof. The coating desirably contains a copolymer containing a recurring unit which contains a group represented by formula (a) and a recurring unit which contains a group represented by formula (b). wherein Ua1, Ua2, Ua3, Ub1, Ub2, Ub3 and An− are as defined herein.

    BASE MATERIAL FOR CELL CULTURE IN SERUM-FREE MEDIUM
    7.
    发明公开
    BASE MATERIAL FOR CELL CULTURE IN SERUM-FREE MEDIUM 审中-公开

    公开(公告)号：US20240336891A1

    公开(公告)日：2024-10-10

    申请号：US18575926

    申请日：2022-07-05

    申请人： NISSAN CHEMICAL CORPORATION

    发明人： Kohei SUZUKI ,  Yuki UEDA ,  Miya HIROI ,  Yoshiomi HIROI ,  Shiho ANNO

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0068 ,  C12N2533/30 ,  C12N2533/50 ,  C12N2533/52

    摘要： Objects of the present invention are to provide a base film for cell culture that enables mass production of homogeneous and high-quality cell aggregates even without the use of a biological serum, and to provide a base film-forming agent for forming the base film, and a substrate for producing cell aggregate. The present inventors provide a base film-forming agent for cell culture including a polymer, a cell adhesive substance, and a solvent, wherein the polymer contains a repeating unit derived from a monomer of formula (I) below:




    wherein Ua1, Ua2, Ra1, and Ra2 are as described in the specification and the claims.

    COMPOSITION FOR FORMING COATING FILM, COATING FILM, AND CELL CULTURE VESSEL
    8.
    发明公开
    COMPOSITION FOR FORMING COATING FILM, COATING FILM, AND CELL CULTURE VESSEL 审中-公开

    公开(公告)号：US20240287322A1

    公开(公告)日：2024-08-29

    申请号：US18567248

    申请日：2022-06-06

    申请人： Nissan Chemical Corporation

    发明人： Miya HIROI ,  Yoshiomi HIROI ,  Yuki UEDA ,  Kohei SUZUKI ,  Natsuki FUKASAWA

    IPC分类号： C09D5/16 ,  C09D131/04 ,  C12M1/00

    CPC分类号： C09D5/1668 ,  C09D131/04 ,  C12M23/20

    摘要： Provided is a coating film which is obtained by applying a composition for forming a coating film, the composition containing a copolymer, and which is used to suppress adhesion of a biological substance, in which the copolymer is water-insoluble, the copolymer contains a repeating unit (A) represented by the following Formula (A) and a repeating unit (B) represented by the following Formula (B), and a molar ratio (A:B) of the repeating unit (A) to the repeating unit (B) in the copolymer is 89:11 to 50:50.




    (In the formula, R1 to R3 each independently represent a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and X1 and X2 each independently represent a single bond, an ester bond, an ether bond, an amide bond, or an alkylene group having 1 to 5 carbon atoms which may be interrupted by an oxygen atom.)

    CELL CULTURE CONTAINER CAPABLE OF LONG-TERM CULTURE AND METHOD FOR MANUFACTURING SAME
    9.
    发明申请
    CELL CULTURE CONTAINER CAPABLE OF LONG-TERM CULTURE AND METHOD FOR MANUFACTURING SAME 审中-公开

    公开(公告)号：US20200369999A1

    公开(公告)日：2020-11-26

    申请号：US16767527

    申请日：2018-11-29

    申请人： NISSAN CHEMICAL CORPORATION

    发明人： Kohei SUZUKI ,  Yoshiomi HIROI ,  Masashi IWAKAMI ,  Taito NISHINO

    IPC分类号： C12M1/00 ,  C12M1/34 ,  C09D185/02 ,  C09D201/06

    摘要： The present invention provides a cell culture container for long term non-adherent cell culture which comprises having a coating containing a copolymer which is a copolymer having a recurring unit which contains a group represented by the following formula (a), a recurring unit which contains a group represented by the following formula (b), and a recurring unit which contains a group represented by the following formula (c), and a molar ratio of the recurring unit which contains a group represented by the formula (c) being 1 to 50 mol % based on the whole copolymer, provided with at least a part of a surface thereof [wherein, Ua1, Ua2, Ub1, Ub2 and Ub3, Rc, and An− are as defined in the specification and Claims.]

    CELL CULTURE CONTAINER HAVING MINUTE VOLUME
    10.
    发明申请
    CELL CULTURE CONTAINER HAVING MINUTE VOLUME 审中-公开

    公开(公告)号：US20200291339A1

    公开(公告)日：2020-09-17

    申请号：US16650907

    申请日：2018-09-26

    申请人： NISSAN CHEMICAL CORPORATION

    发明人： Yoshiomi HIROI ,  Kohei SUZUKI ,  Natsuki ABE

    IPC分类号： C12M1/00 ,  C09D185/02

    摘要： The invention relates to a cell culture container that inhibits adhesion of cells, a method for manufacturing the same and a method for producing cell aggregates using the same. The cell culture container has a coating film containing a copolymer having a recurring unit which contains a group represented by formula (a) and a recurring unit which contains a group represented by formula (b): wherein Ua1, Ua2, Ub1, Ub2 and Ub3 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms, and An− represents an anion selected from the group consisting of a halide ion, an inorganic acid ion, a hydroxide ion and an isothiocyanate ion, on at least a part of a surface of the container, and the volume of the container is 20 μL or less.