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公开(公告)号：US20180318266A1
公开(公告)日：2018-11-08
申请号：US15972939
申请日：2018-05-07
发明人： Takeshi MITA , Takamasa Kikuchi , Takashi Mizukoshi , Manabu Yaosaka , Mitsuaki Komoda , Shinji Takii
IPC分类号： A61K31/421 , C07C25/08 , A01N43/80 , C07C25/02 , C07C25/24 , C07C25/13 , A61K9/00 , C07D413/14 , C07D261/04 , C07F7/08 , C07D417/12 , C07D417/06 , C07D413/12 , C07D413/06 , C07D413/04 , C07D261/16 , C07C323/09 , C07C281/02 , C07C255/60 , C07C255/50 , C07C255/29 , C07C251/48 , C07C211/52 , C07C205/12 , C07C205/11 , C07C43/174 , C07C25/06
摘要： A substituted alkenylbenzene compound of formula (4): wherein X1 is selected from the group consisting of a halogen atom, —SF5, C1-C6haloalkyl, hydroxy C1-C6haloalkyl, C1-C6alkoxy C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6haloalkoxy, C1-C3haloalkoxy C1-C3haloalkoxy, C1-C6haloalkylthio, C1-C6haloalkylsulfinyl and C1-C6haloalkylsulfonyl; X3 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy and C1-C6alkylthio; X4 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, C1-C4alkoxy and C1-C4haloalkoxy; R3 is —C(R3a)(R3b)R3c, where R3a and R3b independently of each other are a halogen atom, or R3a and R3b together form 3- to 6-membered ring together with the carbon atom bonding them by forming a C2-C5haloalkylene chain, and R3c is selected from the group consisting of a hydrogen atom, halogen atom, C1-C5haloalkyl, C1-C4haloalkoxy and C1-C4haloalkylthio, with a proviso that in case where X1 is a fluorine atom, chlorine atom or trifluoromethyl, and both X2 and X3 are a hydrogen atom, in case where both X1 and X2 are fluorine atom and X3 is a hydrogen atom, and in case where both X1 and X2 are trifluoromethyl and X3 is a hydrogen atom, R3c is a hydrogen atom, chlorine atom, bromine atom, iodine atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio.
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公开(公告)号：US10045969B2
公开(公告)日：2018-08-14
申请号：US15097002
申请日：2016-04-12
发明人： Takeshi Mita , Takamasa Kikuchi , Takashi Mizukoshi , Manabu Yaosaka , Mitsuaki Komoda , Shinji Takii
IPC分类号： A61K31/421 , A61K9/00 , C07C25/13 , C07C25/24 , C07C25/02 , C07C25/06 , C07C25/08 , A01N43/80 , C07C43/174 , C07C205/11 , C07C205/12 , C07C211/52 , C07C251/48 , C07C255/29 , C07C255/50 , C07C255/60 , C07C281/02 , C07C323/09 , C07D261/16 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07F7/08 , C07D261/04 , C07D413/14
CPC分类号： A61K31/421 , A01N43/80 , A61K9/0053 , C07C25/02 , C07C25/06 , C07C25/08 , C07C25/13 , C07C25/24 , C07C43/1742 , C07C43/1745 , C07C205/11 , C07C205/12 , C07C211/52 , C07C251/48 , C07C255/29 , C07C255/50 , C07C255/60 , C07C281/02 , C07C323/09 , C07D261/04 , C07D261/16 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07F7/0812
摘要： A substituted alkenylbenzene compound of formula (4): wherein X1 is selected from the group consisting of halogen atom, —SF5, C1-C6halo alkyl, hydroxy C1-C6haloalkyl, C1-C6alkoxy C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6 haloalkoxy, C1-C3haloalkoxy C1-C3haloalkoxy, C1-C6haloalkylthio, C1-C6haloalkylsulfinyl and C1-C6haloalkylsulfonyl; X3 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy and C1-C6 alkylthio; X4 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, C1-C4alkyl, C1-C4alkoxy and C1-C4haloalkoxy; R3 is —C(R3a)(R3b)R3c, where R3a and R3b independently of each other are a halogen atom, or R3a and R3b together form 3- to 6-membered ring together with the carbon atom bonding them by forming a C2-C5haloalkylene chain, and R3c is selected from the group consisting of a hydrogen atom, halogen atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy and C1-C4haloalkylthio, with a proviso that in case where X1 is a fluorine atom, chlorine atom or trifluoromethyl, and both X2 and X3 are a hydrogen atom, in case where both X1 and X2 are fluorine atom and X3 is a hydrogen atom, and in case where both X1 and X2 are trifluoromethyl and X3 is a hydrogen atom, R3c is a hydrogen atom, chlorine atom, bromine atom, iodine atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio.
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公开(公告)号：US08946492B2
公开(公告)日：2015-02-03
申请号：US13850067
申请日：2013-03-25
IPC分类号： C07C25/02 , C07C25/06 , C07C25/08 , C07C25/13 , C07C25/24 , C07D413/14 , A01N43/80 , C07C43/174 , C07C205/11 , C07C205/12 , C07C211/52 , C07C251/48 , C07C255/29 , C07C255/50 , C07C255/60 , C07C281/02 , C07C323/09 , C07D261/16 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07F7/08 , C07D261/04
CPC分类号： A61K31/421 , A01N43/80 , A61K9/0053 , C07C25/02 , C07C25/06 , C07C25/08 , C07C25/13 , C07C25/24 , C07C43/1742 , C07C43/1745 , C07C205/11 , C07C205/12 , C07C211/52 , C07C251/48 , C07C255/29 , C07C255/50 , C07C255/60 , C07C281/02 , C07C323/09 , C07D261/04 , C07D261/16 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07F7/0812
摘要： A substituted alkenylbenzene compound of formula (4): wherein X1 is selected from the group consisting of a halogen atom, —SF5, C1-C6haloalkyl, hydroxy C1-C6haloalkyl, C1-C6alkoxy C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6haloalkoxy, C1-C3haloalkoxy C1-C3haloalkoxy, C1-C6haloalkylthio, C1-C6haloalkylsulfinyl and C1-C6haloalkylsulfonyl; X3 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy and C1-C6alkylthio; X4 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, C1-C4alkyl, C1-C4alkoxy and C1-C4haloalkoxy; R3 is —C(R3a)(R3b)R3c, where R3a and R3b independently of each other are a halogen atom, or R3a and R3b together form 3- to 6-membered ring together with the carbon atom bonding them by forming a C2-C5haloalkylene chain, and R3c is selected from the group consisting of a hydrogen atom, halogen atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy and C1-C4haloalkylthio, with a proviso that in case where X1 is a fluorine atom, chlorine atom or trifluoromethyl, and both X2 and X3 are a hydrogen atom, in case where both X1 and X2 are fluorine atom and X3 is a hydrogen atom, and in case where both X1 and X2 are trifluoromethyl and X3 is a hydrogen atom, R3c is a hydrogen atom, chlorine atom, bromine atom, iodine atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio.
摘要翻译： 式（4）的取代烯基苯化合物：其中X 1选自卤素原子，-SF 5，C 1 -C 6卤代烷基，羟基C 1 -C 6卤代烷基，C 1 -C 6烷氧基C 1 -C 6卤代烷基，C 3 -C 8卤代环烷基，C 1 -C 6卤代烷氧基， C 1 -C 3卤代烷氧基C 1 -C 3卤代烷氧基，C 1 -C 6卤代烷硫基，C 1 -C 6卤代烷基亚磺酰基和C 1 -C 6卤代烷基磺酰基; X 3选自氢原子，卤素原子，氰基，硝基，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 1 -C 6烷氧基和C 1 -C 6烷硫基; X 4选自氢原子，卤素原子，氰基，C 1 -C 4烷基，C 1 -C 4烷氧基和C 1 -C 4卤代烷氧基; R3是-C（R3a）（R3b）R3c，其中R3a和R3b彼此独立地是卤素原子，或者R3a和R3b与通过形成C2- C5卤代烷基链，R3c选自氢原子，卤素原子，C1-C5烷基，C1-C5卤代烷基，C1-C4卤代烷氧基和C1-C4卤代烷硫基，条件是在X1为氟原子的情况下，氯原子 或三氟甲基，X2和X3均为氢原子，X1和X2均为氟原子，X3为氢原子的情况下，X1和X2均为三氟甲基，X3为氢原子时，R3c为 氢原子，氯原子，溴原子，碘原子，C1-C5烷基，C1-C5卤代烷基，C1-C4卤代烷氧基或C1-C4卤代烷硫基。
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