公开(公告)号：US20180318266A1

公开(公告)日：2018-11-08

申请号：US15972939

申请日：2018-05-07

申请人： NISSAN CHEMICAL INDUSTRIES, LTD.

发明人： Takeshi MITA ,  Takamasa Kikuchi ,  Takashi Mizukoshi ,  Manabu Yaosaka ,  Mitsuaki Komoda ,  Shinji Takii

IPC分类号： A61K31/421 ,  C07C25/08 ,  A01N43/80 ,  C07C25/02 ,  C07C25/24 ,  C07C25/13 ,  A61K9/00 ,  C07D413/14 ,  C07D261/04 ,  C07F7/08 ,  C07D417/12 ,  C07D417/06 ,  C07D413/12 ,  C07D413/06 ,  C07D413/04 ,  C07D261/16 ,  C07C323/09 ,  C07C281/02 ,  C07C255/60 ,  C07C255/50 ,  C07C255/29 ,  C07C251/48 ,  C07C211/52 ,  C07C205/12 ,  C07C205/11 ,  C07C43/174 ,  C07C25/06

摘要： A substituted alkenylbenzene compound of formula (4): wherein X1 is selected from the group consisting of a halogen atom, —SF5, C1-C6haloalkyl, hydroxy C1-C6haloalkyl, C1-C6alkoxy C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6haloalkoxy, C1-C3haloalkoxy C1-C3haloalkoxy, C1-C6haloalkylthio, C1-C6haloalkylsulfinyl and C1-C6haloalkylsulfonyl; X3 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy and C1-C6alkylthio; X4 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, C1-C4alkoxy and C1-C4haloalkoxy; R3 is —C(R3a)(R3b)R3c, where R3a and R3b independently of each other are a halogen atom, or R3a and R3b together form 3- to 6-membered ring together with the carbon atom bonding them by forming a C2-C5haloalkylene chain, and R3c is selected from the group consisting of a hydrogen atom, halogen atom, C1-C5haloalkyl, C1-C4haloalkoxy and C1-C4haloalkylthio, with a proviso that in case where X1 is a fluorine atom, chlorine atom or trifluoromethyl, and both X2 and X3 are a hydrogen atom, in case where both X1 and X2 are fluorine atom and X3 is a hydrogen atom, and in case where both X1 and X2 are trifluoromethyl and X3 is a hydrogen atom, R3c is a hydrogen atom, chlorine atom, bromine atom, iodine atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio.

公开(公告)号：US10045969B2

公开(公告)日：2018-08-14

申请号：US15097002

申请日：2016-04-12

申请人： NISSAN CHEMICAL INDUSTRIES, LTD.

发明人： Takeshi Mita ,  Takamasa Kikuchi ,  Takashi Mizukoshi ,  Manabu Yaosaka ,  Mitsuaki Komoda ,  Shinji Takii

IPC分类号： A61K31/421 ,  A61K9/00 ,  C07C25/13 ,  C07C25/24 ,  C07C25/02 ,  C07C25/06 ,  C07C25/08 ,  A01N43/80 ,  C07C43/174 ,  C07C205/11 ,  C07C205/12 ,  C07C211/52 ,  C07C251/48 ,  C07C255/29 ,  C07C255/50 ,  C07C255/60 ,  C07C281/02 ,  C07C323/09 ,  C07D261/16 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07F7/08 ,  C07D261/04 ,  C07D413/14

CPC分类号： A61K31/421 ,  A01N43/80 ,  A61K9/0053 ,  C07C25/02 ,  C07C25/06 ,  C07C25/08 ,  C07C25/13 ,  C07C25/24 ,  C07C43/1742 ,  C07C43/1745 ,  C07C205/11 ,  C07C205/12 ,  C07C211/52 ,  C07C251/48 ,  C07C255/29 ,  C07C255/50 ,  C07C255/60 ,  C07C281/02 ,  C07C323/09 ,  C07D261/04 ,  C07D261/16 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07F7/0812

摘要： A substituted alkenylbenzene compound of formula (4): wherein X1 is selected from the group consisting of halogen atom, —SF5, C1-C6halo alkyl, hydroxy C1-C6haloalkyl, C1-C6alkoxy C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6 haloalkoxy, C1-C3haloalkoxy C1-C3haloalkoxy, C1-C6haloalkylthio, C1-C6haloalkylsulfinyl and C1-C6haloalkylsulfonyl; X3 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy and C1-C6 alkylthio; X4 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, C1-C4alkyl, C1-C4alkoxy and C1-C4haloalkoxy; R3 is —C(R3a)(R3b)R3c, where R3a and R3b independently of each other are a halogen atom, or R3a and R3b together form 3- to 6-membered ring together with the carbon atom bonding them by forming a C2-C5haloalkylene chain, and R3c is selected from the group consisting of a hydrogen atom, halogen atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy and C1-C4haloalkylthio, with a proviso that in case where X1 is a fluorine atom, chlorine atom or trifluoromethyl, and both X2 and X3 are a hydrogen atom, in case where both X1 and X2 are fluorine atom and X3 is a hydrogen atom, and in case where both X1 and X2 are trifluoromethyl and X3 is a hydrogen atom, R3c is a hydrogen atom, chlorine atom, bromine atom, iodine atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio.

公开(公告)号：US08946492B2

公开(公告)日：2015-02-03

申请号：US13850067

申请日：2013-03-25

申请人： Nissan Chemical Industries, Ltd.

发明人： Takeshi Mita ,  Takamasa Kikuchi ,  Takashi Mizukoshi ,  Manabu Yaosaka ,  Mitsuaki Komoda

IPC分类号： C07C25/02 ,  C07C25/06 ,  C07C25/08 ,  C07C25/13 ,  C07C25/24 ,  C07D413/14 ,  A01N43/80 ,  C07C43/174 ,  C07C205/11 ,  C07C205/12 ,  C07C211/52 ,  C07C251/48 ,  C07C255/29 ,  C07C255/50 ,  C07C255/60 ,  C07C281/02 ,  C07C323/09 ,  C07D261/16 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07F7/08 ,  C07D261/04

CPC分类号： A61K31/421 ,  A01N43/80 ,  A61K9/0053 ,  C07C25/02 ,  C07C25/06 ,  C07C25/08 ,  C07C25/13 ,  C07C25/24 ,  C07C43/1742 ,  C07C43/1745 ,  C07C205/11 ,  C07C205/12 ,  C07C211/52 ,  C07C251/48 ,  C07C255/29 ,  C07C255/50 ,  C07C255/60 ,  C07C281/02 ,  C07C323/09 ,  C07D261/04 ,  C07D261/16 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07F7/0812

摘要： A substituted alkenylbenzene compound of formula (4): wherein X1 is selected from the group consisting of a halogen atom, —SF5, C1-C6haloalkyl, hydroxy C1-C6haloalkyl, C1-C6alkoxy C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6haloalkoxy, C1-C3haloalkoxy C1-C3haloalkoxy, C1-C6haloalkylthio, C1-C6haloalkylsulfinyl and C1-C6haloalkylsulfonyl; X3 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy and C1-C6alkylthio; X4 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, C1-C4alkyl, C1-C4alkoxy and C1-C4haloalkoxy; R3 is —C(R3a)(R3b)R3c, where R3a and R3b independently of each other are a halogen atom, or R3a and R3b together form 3- to 6-membered ring together with the carbon atom bonding them by forming a C2-C5haloalkylene chain, and R3c is selected from the group consisting of a hydrogen atom, halogen atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy and C1-C4haloalkylthio, with a proviso that in case where X1 is a fluorine atom, chlorine atom or trifluoromethyl, and both X2 and X3 are a hydrogen atom, in case where both X1 and X2 are fluorine atom and X3 is a hydrogen atom, and in case where both X1 and X2 are trifluoromethyl and X3 is a hydrogen atom, R3c is a hydrogen atom, chlorine atom, bromine atom, iodine atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio.

摘要翻译： 式（4）的取代烯基苯化合物：其中X 1选自卤素原子，-SF 5，C 1 -C 6卤代烷基，羟基C 1 -C 6卤代烷基，C 1 -C 6烷氧基C 1 -C 6卤代烷基，C 3 -C 8卤代环烷基，C 1 -C 6卤代烷氧基， C 1 -C 3卤代烷氧基C 1 -C 3卤代烷氧基，C 1 -C 6卤代烷硫基，C 1 -C 6卤代烷基亚磺酰基和C 1 -C 6卤代烷基磺酰基; X 3选自氢原子，卤素原子，氰基，硝基，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 1 -C 6烷氧基和C 1 -C 6烷硫基; X 4选自氢原子，卤素原子，氰基，C 1 -C 4烷基，C 1 -C 4烷氧基和C 1 -C 4卤代烷氧基; R3是-C（R3a）（R3b）R3c，其中R3a和R3b彼此独立地是卤素原子，或者R3a和R3b与通过形成C2- C5卤代烷基链，R3c选自氢原子，卤素原子，C1-C5烷基，C1-C5卤代烷基，C1-C4卤代烷氧基和C1-C4卤代烷硫基，条件是在X1为氟原子的情况下，氯原子 或三氟甲基，X2和X3均为氢原子，X1和X2均为氟原子，X3为氢原子的情况下，X1和X2均为三氟甲基，X3为氢原子时，R3c为 氢原子，氯原子，溴原子，碘原子，C1-C5烷基，C1-C5卤代烷基，C1-C4卤代烷氧基或C1-C4卤代烷硫基。

公开(公告)号：US20130296559A1

公开(公告)日：2013-11-07

申请号：US13850067

申请日：2013-03-25

申请人： Nissan Chemical Industries, Ltd

发明人： Takeshi MITA ,  Takamase Kikuchi ,  Takashi Mizukoshi ,  Manabu Yaosaka ,  Mitsuaki Komoda

IPC分类号： C07D413/14 ,  C07D413/12 ,  C07D261/04

CPC分类号： A61K31/421 ,  A01N43/80 ,  A61K9/0053 ,  C07C25/02 ,  C07C25/06 ,  C07C25/08 ,  C07C25/13 ,  C07C25/24 ,  C07C43/1742 ,  C07C43/1745 ,  C07C205/11 ,  C07C205/12 ,  C07C211/52 ,  C07C251/48 ,  C07C255/29 ,  C07C255/50 ,  C07C255/60 ,  C07C281/02 ,  C07C323/09 ,  C07D261/04 ,  C07D261/16 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07F7/0812

摘要： A substituted alkenylbenzene compound of formula (4): wherein X1 is selected from the group consisting of a halogen atom, —SF5, C1-C6haloalkyl, hydroxy C1-C6haloalkyl, C1-C6alkoxy C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6haloalkoxy, C1-C3haloalkoxy C1-C3haloalkoxy, C1-C6haloalkylthio, C1-C6haloalkylsulfinyl and C1-C6haloalkylsulfonyl; X3 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy and C1-C6alkylthio; X4 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, C1-C4alkyl, C1-C4alkoxy and C1-C4haloalkoxy; R3 is —C(R3a)(R3b)R3c, where R3a and R3b independently of each other are a halogen atom, or R3a and R3b together form 3- to 6-membered ring together with the carbon atom bonding them by forming a C2-C5haloalkylene chain, and R3c is selected from the group consisting of a hydrogen atom, halogen atom. C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy and C1-C4haloalkylthio, with a proviso that in case where X1 is a fluorine atom, chlorine atom or trifluoromethyl, and both X2 and X3 are a hydrogen atom, in case where both X1 and X2 are fluorine atom and X3 is a hydrogen atom, and in case where both X1 and X2 are trifluoromethyl and X3 is a hydrogen atom. R3c is a hydrogen atom, chlorine atom, bromine atom, iodine atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio.

摘要翻译： 式（4）的取代烯基苯化合物：其中X 1选自卤素原子，-SF 5，C 1 -C 6卤代烷基，羟基C 1 -C 6卤代烷基，C 1 -C 6烷氧基C 1 -C 6卤代烷基，C 3 -C 8卤代环烷基，C 1 -C 6卤代烷氧基， C 1 -C 3卤代烷氧基C 1 -C 3卤代烷氧基，C 1 -C 6卤代烷硫基，C 1 -C 6卤代烷基亚磺酰基和C 1 -C 6卤代烷基磺酰基; X 3选自氢原子，卤素原子，氰基，硝基，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 1 -C 6烷氧基和C 1 -C 6烷硫基; X 4选自氢原子，卤素原子，氰基，C 1 -C 4烷基，C 1 -C 4烷氧基和C 1 -C 4卤代烷氧基; R3是-C（R3a）（R3b）R3c，其中R3a和R3b彼此独立地是卤素原子，或者R3a和R3b与通过形成C2- C5卤代亚烷基，R3c选自氢原子，卤素原子。 C1-C5烷基，C1-C5卤代烷基，C1-C4卤代烷氧基和C1-C4卤代烷硫基，条件是在X1为氟原子，氯原子或三氟甲基的情况下，X2和X3均为氢原子，在X1和 X2为氟原子，X3为氢原子，X1和X2均为三氟甲基，X3为氢原子的情况。 R3c是氢原子，氯原子，溴原子，碘原子，C1-C5烷基，C1-C5卤代烷基，C1-C4卤代烷氧基或C1-C4卤代烷硫基。

公开(公告)号：US08796464B2

公开(公告)日：2014-08-05

申请号：US13757045

申请日：2013-02-01

申请人： Nissan Chemical Industries, Ltd.

发明人： Yuji Moriyama ,  Takashi Mizukoshi

IPC分类号： C07D261/04

CPC分类号： C07D261/04

摘要： A production method of an isoxazoline-substituted benzoic acid amide compound of Formula (1) where X is a halogen atom, C1-6 haloalkyl, etc., Y is a halogen atom, C1-6 alkyl, etc., R1 is a C1-6 haloalkyl, etc., R2 and R3 independently of each other are a hydrogen atom, C1-6 alkyl, etc., R4 is C1-6 alkyl, C1-6 haloalkyl, etc., R5 is a hydrogen atom, C1-6 alkyl, etc., m is an integer of 0 to 5, n is an integer of 0 to 4, including: reacting an isoxazoline-substituted benzene compound of Formula (3) where X, Y, R1, m, and n are the same as defined above, L is a chlorine atom, a bromine atom, —C(O)OH, —C(O)J, etc., J is a halogen atom, with a 2-aminoacetic acid amide compound of Formula (2) where R2, R3, R4, and R5 are the same as defined above, or a salt thereof; crystal forms and the production method thereof.

摘要翻译： 其中X是卤素原子，C 1-6卤代烷基等的式（1）的异恶唑啉取代的苯甲酸酰胺化合物的制备方法，Y是卤素原子，C 1-6烷基等，R 1是C 1 -6卤代烷基等，R2和R3彼此独立地是氢原子，C1-6烷基等，R4是C1-6烷基，C1-6卤代烷基等，R5是氢原子，C1- 6烷基等，m为0〜5的整数，n为0〜4的整数，包括：使式（3）的异恶唑啉取代的苯化合物，其中X，Y，R 1，m和n分别为 与上述相同，L是氯原子，溴原子，-C（O）OH，-C（O）J等，J是卤素原子，与式（2）的2-氨基乙酰胺化合物 2）其中R2，R3，R4和R5与上述定义相同，或其盐; 晶体形式及其制备方法。

公开(公告)号：US20130144066A1

公开(公告)日：2013-06-06

申请号：US13757045

申请日：2013-02-01

申请人： Nissan Chemical Industries, Ltd.

发明人： Hiroyuki KOUSAKA ,  Shunsuke Fukuya ,  Yuji Moriyama ,  Manabu Yaosaka ,  Takashi Mizukoshi

IPC分类号： C07D261/04

CPC分类号： C07D261/04

摘要： A production method of an isoxazoline-substituted benzoic acid amide compound of Formula (1) where X is a halogen atom, C1-6 haloalkyl, etc., Y is a halogen atom, C1-6 alkyl, etc., R1 is a C1-6 haloalkyl, etc., R2 and R3 independently of each other are a hydrogen atom, C1-6 alkyl, etc., R4 is C1-6 alkyl, C1-6 haloalkyl, etc., R5 is a hydrogen atom, C1-6 alkyl, etc., m is an integer of 0 to 5, n is an integer of 0 to 4, including: reacting an isoxazoline-substituted benzene compound of Formula (3) where X, Y, R1, m, and n are the same as defined above, L is a chlorine atom, a bromine atom, —C(O)OH, —C(O)J, etc., J is a halogen atom, with a 2-aminoacetic acid amide compound of Formula (2) where R2, R3, R4, and R5 are the same as defined above, or a salt thereof; crystal forms and the production method thereof.

摘要翻译： 其中X是卤素原子，C 1-6卤代烷基等的式（1）的异恶唑啉取代的苯甲酸酰胺化合物的制备方法，Y是卤素原子，C 1-6烷基等，R 1是C 1 -6卤代烷基等，R2和R3彼此独立地是氢原子，C1-6烷基等，R4是C1-6烷基，C1-6卤代烷基等，R5是氢原子，C1- 6烷基等，m为0〜5的整数，n为0〜4的整数，包括：使式（3）的异恶唑啉取代的苯化合物，其中X，Y，R 1，m和n分别为 与上述相同，L是氯原子，溴原子，-C（O）OH，-C（O）J等，J是卤素原子，与式（2）的2-氨基乙酰胺化合物 2）其中R2，R3，R4和R5与上述定义相同，或其盐; 晶体形式及其制备方法。