专利检索 ap:("NITTO DENKO CORPORATION") AND inv:"Yun Liu" 第 1 页

1.

发明授权
Method for treating fibrosis using siRNA and a retinoid-lipid drug carrier 有权

公开(公告)号：US10195145B2

公开(公告)日：2019-02-05

申请号：US15283179

申请日：2016-09-30

申请人： Nitto Denko Corporation

发明人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu

IPC分类号： C12N15/113 , A61K9/127 , C12N15/11 , A61K31/713 , C07H21/02

摘要： What is described is a method for treating a fibrotic disease by administering a pharmaceutical composition comprising a drug carrier, which comprises a lipid and a retinoid, and a double-stranded nucleic acid molecule, which comprises an antisense sequence to mRNA encoding human hsp47.

2.

发明申请
RETINOID-LIPID DRUG CARRIER 审中-公开

公开(公告)号：US20170081663A1

公开(公告)日：2017-03-23

申请号：US15284494

申请日：2016-10-03

申请人： Nitto Denko Corporation

发明人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu , Zheng Hou , John A. Gaudette , Priya Karmali , Sridhar C. Nagarajan

IPC分类号： C12N15/113 , A61K47/18 , A61K47/24 , A61K31/713

CPC分类号： C12N15/113 , A61K9/0048 , A61K9/127 , A61K9/1271 , A61K31/713 , A61K45/06 , A61K47/18 , A61K47/186 , A61K47/24 , C07H21/02 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2320/32

摘要： What is described is a pharmaceutical composition for treating a fibrotic disease comprising a drug carrier, which comprises a lipid and a retinoid, and a double-stranded nucleic acid molecule, which comprises an antisense sequence to mRNA encoding human hsp47.

3.

发明授权
Method for treating fibrosis using siRNA and a retinoid-lipid drug carrier 有权
标题翻译：使用siRNA和类视黄醇 - 脂质药物载体治疗纤维化的方法

公开(公告)号：US09456984B2

公开(公告)日：2016-10-04

申请号：US14294021

申请日：2014-06-02

申请人： NITTO DENKO CORPORATION

发明人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu

IPC分类号： C12N15/11 , A61K9/127 , C12N15/113 , A61K31/713 , C07H21/02

CPC分类号： A61K9/1271 , A61K9/127 , A61K31/713 , C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2320/32 , C12N2320/52

摘要： What is described is a method for treating a fibrotic disease by administering a pharmaceutical composition comprising a drug carrier, which comprises a lipid and a retinoid, and a double-stranded nucleic acid molecule, which comprises an antisense sequence to mRNA encoding human hsp47.

摘要翻译： 描述的是通过施用包含脂质和类视色素的药物载体和包含与编码人hsp47的mRNA的反义序列的双链核酸分子的药物组合物来治疗纤维化疾病的方法。

4.

发明申请
THERAPEUTIC COMPOSITIONS AND METHODS FOR MALIGNANT TUMORS WITH RNAI MOLECULES TARGETED TO HSP47 AND P21 审中-公开
标题翻译：具有针对HSP47和P21的RNAi分子的恶性肿瘤的治疗组合物和方法

公开(公告)号：US20160215286A1

公开(公告)日：2016-07-28

申请号：US14979577

申请日：2015-12-28

申请人： Nitto Denko Corporation

发明人： Yoshiro Niitsu , Akihiro Yoneda , Yasuyuki Tamura , Kenjirou Minomi , Bharat Majeti , Jihua Liu , Yun Liu , Wenbin Ying

IPC分类号： C12N15/113

CPC分类号： A61B5/0071 , A61K31/713 , A61K49/0021 , C07D311/30 , C07F9/6533 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N2310/14 , C12N2310/322 , C12N2310/344 , C12N2310/3515 , C12N2310/531 , C12N2320/30 , C12N2320/32 , C12N2320/35 , C12N2320/53 , C12Q1/02 , G01N33/582 , H05K999/99 , C12N2310/3533 , C12N2310/3531 , C12N2310/321 , C12N2310/3521

摘要： This invention provides compositions and methods for preventing or treating a malignant tumor in a mammal in need thereof, by administering to the mammal a therapeutically effective amount of a composition comprising RNAi molecules, which RNAi molecules can be active in reducing expression of Hsp47, or a combination of RNAi molecules active for Hsp47 and p21.

摘要翻译： 本发明提供了通过向哺乳动物施用治疗有效量的包含RNAi分子的组合物来预防或治疗有需要的哺乳动物的恶性肿瘤的组合物和方法，该RNAi分子可以有效地降低Hsp47的表达，或用于Hsp47和p21的RNAi分子的组合。

5.

发明申请
RNA INTERFERENCE COMPOSITIONS AND METHODS FOR MALIGNANT TUMORS 有权
标题翻译： RNA干扰组合物和恶性肿瘤的方法

公开(公告)号：US20160186182A1

公开(公告)日：2016-06-30

申请号：US14979566

申请日：2015-12-28

申请人： Nitto Denko Corporation

发明人： Yoshiro Niitsu , Kenjirou Minomi , Bharat Majeti , Jens Harborth , Li Wang , Jihua Liu , Yun Liu , Roger Adami , Wenbin Ying

IPC分类号： C12N15/113

CPC分类号： C07F9/6533 , A61K31/713 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N2310/14 , C12N2310/322 , C12N2310/344 , C12N2310/3515 , C12N2310/531 , C12N2320/30 , C12N2320/32 , C12N2320/35 , C12N2320/53 , C12Q1/02 , G01N33/582 , H05K999/99 , C12N2310/3533 , C12N2310/3531 , C12N2310/321 , C12N2310/3521

摘要： This invention provides compositions for use in distributing active agents for treating a malignant tumor in a subject. The compositions contain RNAi molecules targeted to a human GST-π, along with RNAi molecules targeted to a human p21, and a pharmaceutically acceptable carrier. The carrier can include nanoparticles composed of an ionizable lipid, a structural lipid, one or more stabilizer lipids, and a lipid for reducing immunogenicity of the nanoparticles. This invention further provides methods for preventing or treating a malignant tumor by administering a therapeutically effective amount of an RNAi composition.

摘要翻译： 本发明提供用于分配用于治疗受试者的恶性肿瘤的活性剂的组合物。组合物含有靶向人GST-pgr的RNAi分子以及靶向人p21的RNAi分子和药学上可接受的载体。载体可以包括由可电离脂质，结构脂质，一种或多种稳定剂脂质和用于降低纳米颗粒的免疫原性的脂质组成的纳米颗粒。本发明还提供了通过施用治疗有效量的RNAi组合物来预防或治疗恶性肿瘤的方法。