公开(公告)号：US10654797B2

公开(公告)日：2020-05-19

申请号：US16343165

申请日：2017-11-02

Applicant: NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED

Inventor： Huiqing Ye ,  Jinchao Xu ,  Bifei He ,  Guangyuan Liu ,  Yuping Fan ,  Zhongqing Wang ,  Zhonghua Luo

IPC: C07C271/24 ,  A61K31/27 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55

Abstract: Provided herein are crystalline forms of (((((1r, 3R, 5S, 7r)-3, 5-dimethyladamantan-1-yl)carbamoyl) oxy) methyl benzoate (Compound (I)): Also provided are compositions comprising the crystalline forms of Compound (I), processes of manufacture and methods of using the crystalline forms of Compound (I).

公开(公告)号：US11370739B2

公开(公告)日：2022-06-28

申请号：US16679154

申请日：2019-11-09

Applicant: NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED

Inventor： Lei Chen ,  Guodong Sun ,  Xiaodong Han ,  Shun Li ,  Jiebin Zeng ,  Zhongqing Wang ,  Zhonghua Luo

IPC: C07C59/205 ,  C07C231/02 ,  C07C233/47 ,  C07C51/09 ,  C12P13/00 ,  C07C235/78 ,  C07C59/84 ,  C07C69/738 ,  C07C49/245 ,  C07C49/255 ,  C07D498/04 ,  C07C45/65 ,  C07C49/35 ,  C07C67/317 ,  C07C69/716 ,  C07C231/12 ,  C07C233/11 ,  C07F7/18

Abstract: The present invention relates to a sacubitril intermediate and a preparation method thereof. The sacubitril intermediate disclosed herein can be prepared by a deprotection reaction of a compound. In addition, the intermediate can be used as a raw material to synthesize sacubitril.