公开(公告)号：US11548897B2

公开(公告)日：2023-01-10

申请号：US17371399

申请日：2021-07-09

Applicant: NOVARTIS AG

Inventor： Ying Huang ,  Bo Liu ,  Liang Mao ,  Long Wang ,  Liladhar Murlidhar Waykole ,  Lijun Zhang

IPC: C07D487/04 ,  A61P35/00 ,  A61P35/02 ,  A61K31/519

Abstract: Provided herein are crystalline forms of a triazolopyrimidine compound, which is useful for treating a PRC2-mediated disease or disorder.

公开(公告)号：US20170112868A1

公开(公告)日：2017-04-27

申请号：US15378576

申请日：2016-12-14

Applicant: Novartis AG

Inventor： Sampath-Kumar Anandan ,  Virender Singh Aulakh ,  Martijn Fenaux ,  Xiaodong Lin ,  Liang Mao ,  Oliver Saunders ,  Zachary Kevin Sweeney ,  Fumiaki Yokokawa ,  Weidong Zhong

IPC: A61K31/7072 ,  A61K45/06 ,  A61K47/22 ,  C07H19/06

CPC classification number: A61K31/7072 ,  A61K31/7068 ,  A61K45/06 ,  A61K47/22 ,  C07H19/06 ,  C07H19/067 ,  C07H19/10

Abstract: The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.

公开(公告)号：US08815926B2

公开(公告)日：2014-08-26

申请号：US13748790

申请日：2013-01-24

Applicant: Novartis AG

Inventor： Pascal Furet ,  Vito Guagnano ,  Philipp Holzer ,  Joerg Kallen ,  Lv Liao ,  Robert Mah ,  Liang Mao ,  Keiichi Masuya ,  Achim Schlapbach ,  Stefan Stutz ,  Andrea Vaupel

IPC: A61K31/4188 ,  C07D235/02 ,  C07D487/04 ,  A61K45/06 ,  A61K31/541 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/501

CPC classification number: C07D487/04 ,  A61K31/4188 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06

Abstract: The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.

Abstract translation: 本发明涉及式（I）化合物：如本文所述，包含这些化合物的药物制剂，用于治疗由MDM2和/或MDM4的活性介导的疾病或疾病的这些化合物的用途和方法，以及 包含这些化合物的组合。

公开(公告)号：US11091489B2

公开(公告)日：2021-08-17

申请号：US16311638

申请日：2017-06-19

Applicant: NOVARTIS AG

Inventor： Ying Huang ,  Bo Liu ,  Liang Mao ,  Long Wang ,  Liladhar Murlidhar Waykole ,  Lijun Zhang

IPC: C07D487/04 ,  A61P35/00 ,  A61P35/02 ,  A61K31/519

Abstract: Provided herein are crystalline forms of a triazolopyrimidine compound, which is useful for treating a PRC2-mediated disease or disorder.

公开(公告)号：US20210340152A1

公开(公告)日：2021-11-04

申请号：US17371399

申请日：2021-07-09

Applicant: NOVARTIS AG

Inventor： Ying Huang ,  Bo Liu ,  Liang Mao ,  Long Wang ,  Liladhar Murlidhar Waykole ,  Lijun Zhang

IPC: C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  A61P35/02

Abstract: Provided herein are crystalline forms of a triazolopyrimidine compound, which is useful for treating a PRC2-mediated disease or disorder.

公开(公告)号：US09814739B2

公开(公告)日：2017-11-14

申请号：US15378576

申请日：2016-12-14

Applicant: Novartis AG

Inventor： Sampath-Kumar Anandan ,  Virender Singh Aulakh ,  Martijn Fenaux ,  Xiaodong Lin ,  Liang Mao ,  Oliver Saunders ,  Zachary Kevin Sweeney ,  Fumiaki Yokokawa ,  Weidong Zhong

IPC: C07H19/10 ,  A61K31/7072 ,  C07H19/06 ,  A61K45/06 ,  A61K47/22

CPC classification number: A61K31/7072 ,  A61K31/7068 ,  A61K45/06 ,  A61K47/22 ,  C07H19/06 ,  C07H19/067 ,  C07H19/10

Abstract: The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.