公开(公告)号：US10709712B2

公开(公告)日：2020-07-14

申请号：US16274165

申请日：2019-02-12

申请人： NOVARTIS AG

发明人： Robert John Aversa ,  Paul Andrew Barsanti ,  Matthew T. Burger ,  Michael Patrick Dillon ,  Alan Dipesa ,  Cheng Hu ,  Yan Lou ,  Gisele A. Nishiguchi ,  Yue Pan ,  Valery Rostislavovich Polyakov ,  Savithri Ramurthy ,  Alice C. Rico ,  Lina Quattrocchio Setti ,  Aaron Smith ,  Sharadha Subramanian ,  Benjamin R. Taft ,  Huw Roland Tanner ,  Lifeng Wan ,  Naeem Yusuff

IPC分类号： A61K31/5377 ,  C07D413/04 ,  A61K31/541 ,  A61K45/06 ,  C07D213/74 ,  C07D237/20 ,  C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D277/42 ,  C07D401/12 ,  C07D403/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D493/10 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D213/75 ,  C07D233/88 ,  C07D401/04 ,  C07D405/04 ,  C07D405/12 ,  C07D241/20 ,  C07D471/04 ,  C07D487/04 ,  C07D263/58 ,  C07D491/107 ,  C07D493/04 ,  C07D495/04 ,  C07D498/08 ,  C07D513/04 ,  A61K31/5375 ,  C07D213/81 ,  C07D213/82 ,  C07D213/84 ,  C07D237/22 ,  C07D409/14 ,  C07D491/048 ,  A61K31/444 ,  A61K31/501 ,  C07B59/00 ,  C07D237/24 ,  C07D491/04 ,  C07D491/08

摘要： The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.

公开(公告)号：US10392404B2

公开(公告)日：2019-08-27

申请号：US15510613

申请日：2015-09-11

申请人： NOVARTIS AG

发明人： Paul Andrew Barsanti ,  Matthew T. Burger ,  Yan Lou ,  Gisele A. Nishiguchi ,  Valery Rostislavovich Polyakov ,  Savithri Ramurthy ,  Sharadha Subramanian ,  Benjamin R. Taft ,  Huw Rowland Tanner ,  Lifeng Wan

IPC分类号： A61K31/444 ,  C07D498/08 ,  C07D401/14 ,  C07D413/14 ,  C07D213/74 ,  C07D401/04 ,  C07D401/10 ,  C07D407/14 ,  C07D411/14 ,  C07D413/12 ,  A61K31/4418 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/541 ,  C07D213/85 ,  C07D405/12 ,  C07D405/14 ,  C07D451/02

摘要： The present invention provides compounds of Formula (I) and (II) as described herein, and salts thereof and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.

公开(公告)号：US10245267B2

公开(公告)日：2019-04-02

申请号：US15601423

申请日：2017-05-22

申请人： NOVARTIS AG

发明人： Robert John Aversa ,  Paul Andrew Barsanti ,  Matthew T. Burger ,  Michael Patrick Dillon ,  Alan Dipesa ,  Cheng Hu ,  Yan Lou ,  Gisele A. Nishiguchi ,  Yue Pan ,  Valery Rostislavovich Polyakov ,  Savithri Ramurthy ,  Alice C. Rico ,  Lina Quattrocchio Setti ,  Aaron Smith ,  Sharadha Subramanian ,  Benjamin R. Taft ,  Huw Roland Tanner ,  Lifeng Wan ,  Naeem Yusuff

IPC分类号： C07D295/04 ,  A61K31/5377 ,  C07D413/04 ,  A61K31/541 ,  A61K45/06 ,  C07D213/74 ,  C07D237/20 ,  C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D277/42 ,  C07D401/12 ,  C07D403/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D493/10 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D213/75 ,  C07D233/88 ,  C07D401/04 ,  C07D405/04 ,  C07D405/12 ,  C07D241/20 ,  C07D471/04 ,  C07D487/04 ,  C07D263/58 ,  C07D491/107 ,  C07D493/04 ,  C07D495/04 ,  C07D498/08 ,  C07D513/04 ,  A61K31/5375 ,  C07D213/81 ,  C07D213/82 ,  C07D213/84 ,  C07D237/22 ,  C07D409/14 ,  C07D491/048 ,  A61K31/444 ,  A61K31/501 ,  C07B59/00 ,  C07D237/24 ,  C07D491/04 ,  C07D491/08

摘要： The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.