公开(公告)号：US11123419B2

公开(公告)日：2021-09-21

申请号：US16494517

申请日：2018-03-15

申请人： Novavax, Inc.

发明人： Jing-Hui Tian ,  Ye Liu ,  Gale Smith ,  Gregory Glenn ,  David Flyer

IPC分类号： A61K39/116 ,  A61K39/39 ,  A61K39/00

摘要： Disclosed herein are methods and compositions for treating or preventing bacterial infection. In particular, the methods and compositions are directed towards C. difficile infection. In particular aspects, the compositions are vaccines containing multimeric polypeptides containing portions of multiple toxins from bacteria. The polypeptides induce effective immune responses thus treating or preventing infection.

公开(公告)号：US11052146B2

公开(公告)日：2021-07-06

申请号：US16009257

申请日：2018-06-15

申请人： Novavax, Inc.

发明人： Peter M. Pushko ,  Yingyun Wu ,  Michael J. Massare ,  Ye Liu ,  Gale Smith ,  Bin Zhou

IPC分类号： A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  A61K9/00 ,  A61K39/39 ,  A61K9/107 ,  A61K39/00

摘要： The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.

公开(公告)号：US10086065B2

公开(公告)日：2018-10-02

申请号：US15638955

申请日：2017-06-30

申请人： NOVAVAX, INC.

发明人： Gale Smith ,  Ye Liu

IPC分类号： C07K14/005 ,  A61K39/205 ,  A61K39/12 ,  A61K39/00

摘要： The present invention is generally related to virus-like particles (VLPs) comprising rabies virus (RV) glycoproteins (G proteins) and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of rabies virus infection.

公开(公告)号：US09180180B2

公开(公告)日：2015-11-10

申请号：US14149365

申请日：2014-01-07

申请人： NOVAVAX, INC.

发明人： Gale Smith ,  Rick Bright ,  Peter Pushko ,  Jinyou Zhang ,  Kutub Mahmood

IPC分类号： A61K39/145 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  A61K39/12 ,  A61K39/00

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/14143 ,  C12N2760/16023 ,  C12N2760/16034 ,  C12N2760/16071 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134

摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.

公开(公告)号：US09050290B2

公开(公告)日：2015-06-09

申请号：US13890711

申请日：2013-05-09

申请人： Novavax, Inc.

发明人： Gale Smith ,  Rick Bright ,  Peter M. Pushko ,  Jinyou Zhang ,  Kutub Mahmood

IPC分类号： A61K39/145 ,  C12N7/04 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/58 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/14143 ,  C12N2760/16022 ,  C12N2760/16023 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134

摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.

摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLPs）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。

公开(公告)号：US11938179B2

公开(公告)日：2024-03-26

申请号：US17398610

申请日：2021-08-10

申请人： Novavax, Inc.

发明人： Jing-Hui Tian ,  Ye Liu ,  Gale Smith ,  Gregory Glenn ,  David Flyer

IPC分类号： A61K39/116 ,  A61K39/00 ,  A61K39/39

CPC分类号： A61K39/116 ,  A61K39/39 ,  A61K2039/55577 ,  A61K2039/70

摘要： Disclosed herein are methods and compositions for treating or preventing bacterial infection. In particular, the methods and compositions are directed towards C. difficile infection. In particular aspects, the compositions are vaccines containing multimeric polypeptides containing portions of multiple toxins from bacteria. The polypeptides induce effective immune responses thus treating or preventing infection.

公开(公告)号：US11253585B2

公开(公告)日：2022-02-22

申请号：US16545424

申请日：2019-08-20

申请人： Novavax, Inc.

发明人： Gale Smith ,  Ye Liu ,  Jing-Hui Tian ,  Michael J. Massare ,  Sarathi Boddapati ,  Erica Shane ,  Cynthia Oliver ,  Gregory Glenn

IPC分类号： A61K39/155 ,  A61K39/12 ,  C12N7/00 ,  A61K9/00 ,  A61K9/16 ,  A61K39/00

摘要： Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.

公开(公告)号：US10751410B2

公开(公告)日：2020-08-25

申请号：US15023629

申请日：2014-09-19

申请人： NOVAVAX, INC.

发明人： Gale Smith ,  Ye Liu ,  Michael Massare

IPC分类号： C12N7/00 ,  A61K39/145 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K39/215 ,  A61K39/12 ,  A61K39/42 ,  C07K14/005 ,  C07K16/10 ,  A61K39/00

摘要： Disclosed herein are nanoparticles containing MERS virus proteins in polymer structures, and compositions containing the nanoparticles formulated for administration as immunogenic compositions. Also provided herein are vector constructs encoding the proteins, and host cells containing the vector constructs. The disclosure also includes methods of making the nanoparticles and administering them to vertebrates, including methods of inducing immune responses to MERS that reduce or prevent infection by the virus.

公开(公告)号：US10729760B2

公开(公告)日：2020-08-04

申请号：US16210501

申请日：2018-12-05

申请人： Novavax, Inc.

发明人： Gale Smith ,  Rick Bright ,  Peter M. Pushko ,  Jinyou Zhang ,  Kutub Mahmood

IPC分类号： A61K39/145 ,  C07K14/005 ,  C12N7/00 ,  A61K39/12 ,  A61K39/00

摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.

公开(公告)号：US10022437B2

公开(公告)日：2018-07-17

申请号：US14839247

申请日：2015-08-28

申请人： NOVAVAX, INC.

发明人： Peter Pushko ,  Yingyun Wu ,  Michael J. Massare ,  Ye Liu ,  Gale Smith ,  Bin Zhou

IPC分类号： A61K39/155 ,  C07K14/005 ,  A61K39/12 ,  C12N7/00 ,  A61K9/00 ,  A61K39/39 ,  A61K9/107 ,  A61K39/00

摘要： The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.