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公开(公告)号:US11052146B2
公开(公告)日:2021-07-06
申请号:US16009257
申请日:2018-06-15
申请人: Novavax, Inc.
发明人: Peter M. Pushko , Yingyun Wu , Michael J. Massare , Ye Liu , Gale Smith , Bin Zhou
IPC分类号: A61K39/155 , A61K39/12 , C07K14/005 , C12N7/00 , A61K9/00 , A61K39/39 , A61K9/107 , A61K39/00
摘要: The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.
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公开(公告)号:US09464276B2
公开(公告)日:2016-10-11
申请号:US14628513
申请日:2015-02-23
申请人: NOVAVAX, INC.
发明人: Gale Smith , Yingyun Wu , Michael Massare , Peter Pushko , Margaret Nathan , Thomas Kort , Robin Robinson
CPC分类号: C12N7/00 , A61K39/12 , A61K2039/5258 , A61K2039/55505 , A61K2039/55555 , C07K14/005 , C07K2319/01 , C07K2319/03 , C12N9/2402 , C12N2710/14143 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16151 , C12N2760/16171 , C12N2760/16222 , C12N2760/16223 , C12N2760/16251 , C12N2770/20022 , C12N2770/20023 , C12N2770/20051 , C12N2800/22 , C12Y302/01018
摘要: This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using said VLPs.
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公开(公告)号:US20150266930A1
公开(公告)日:2015-09-24
申请号:US14730809
申请日:2015-06-04
申请人: Novavax, Inc.
发明人: Peter PUSHKO , Yingyun Wu , Michael J. Massare , Ye Liu , Gale Smith , Bin Zhou
IPC分类号: C07K14/005 , A61K39/155 , C12N7/00 , A61K9/00 , A61K39/39
CPC分类号: A61K39/155 , A61K9/0019 , A61K9/1075 , A61K39/00 , A61K39/12 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , A61K2039/57 , A61K2039/575 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2760/18522 , C12N2760/18523 , C12N2760/18534 , C12N2760/18562 , C12N2760/18571
摘要: The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.
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公开(公告)号:US10022437B2
公开(公告)日:2018-07-17
申请号:US14839247
申请日:2015-08-28
申请人: NOVAVAX, INC.
发明人: Peter Pushko , Yingyun Wu , Michael J. Massare , Ye Liu , Gale Smith , Bin Zhou
IPC分类号: A61K39/155 , C07K14/005 , A61K39/12 , C12N7/00 , A61K9/00 , A61K39/39 , A61K9/107 , A61K39/00
摘要: The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.
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公开(公告)号:US11446374B2
公开(公告)日:2022-09-20
申请号:US16599568
申请日:2019-10-11
申请人: Novavax, Inc.
发明人: Peter M. Pushko , Yingyun Wu , Michael J. Massare , Ye Liu , Gale Smith , Bin Zhou
IPC分类号: A61K39/155 , A61K39/12 , C07K14/005 , C12N7/00 , A61K9/00 , A61K39/39 , A61K9/107 , A61K39/00
摘要: The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.
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公开(公告)号:US10544399B2
公开(公告)日:2020-01-28
申请号:US15928385
申请日:2018-03-22
申请人: Novavax, Inc.
发明人: Gale Smith , Yingyun Wu , Michael J. Massare , Peter M. Pushko , Margaret Nathan , Thomas Kort , Robin Robinson
IPC分类号: C12N7/00 , C12N9/24 , A61K39/12 , C07K14/005 , A61K39/00
摘要: This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using said VLPs.
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公开(公告)号:US09951317B2
公开(公告)日:2018-04-24
申请号:US15287433
申请日:2016-10-06
申请人: NOVAVAX, INC.
发明人: Gale Smith , Yingyun Wu , Michael J. Massare , Peter M. Pushko , Margaret Nathan , Thomas Kort , Robin Robinson
IPC分类号: A61K39/145 , C12N7/00 , A61K39/12 , C12N9/24 , C07K14/005 , A61K39/00
CPC分类号: C12N7/00 , A61K39/12 , A61K2039/5258 , A61K2039/55505 , A61K2039/55555 , C07K14/005 , C07K2319/01 , C07K2319/03 , C12N9/2402 , C12N2710/14143 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16151 , C12N2760/16171 , C12N2760/16222 , C12N2760/16223 , C12N2760/16251 , C12N2770/20022 , C12N2770/20023 , C12N2770/20051 , C12N2800/22 , C12Y302/01018
摘要: This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using said VLPs.
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公开(公告)号:US09731000B2
公开(公告)日:2017-08-15
申请号:US14730805
申请日:2015-06-04
申请人: NOVAVAX, INC.
发明人: Peter M. Pushko , Yingyun Wu , Michael J. Massare , Ye Liu , Gale Smith , Bin Zhou
IPC分类号: A61K39/155 , C07K14/005 , A61K39/12 , C12N7/00 , A61K9/00 , A61K39/39 , A61K9/107 , A61K39/00
CPC分类号: A61K39/155 , A61K9/0019 , A61K9/1075 , A61K39/00 , A61K39/12 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , A61K2039/57 , A61K2039/575 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2760/18522 , C12N2760/18523 , C12N2760/18534 , C12N2760/18562 , C12N2760/18571
摘要: The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.
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公开(公告)号:US09717786B2
公开(公告)日:2017-08-01
申请号:US14730809
申请日:2015-06-04
申请人: NOVAVAX, INC.
发明人: Peter M. Pushko , Yingyun Wu , Michael J Massare , Ye Liu , Gale Smith , Bin Zhou
IPC分类号: C07K14/005 , A61K39/155 , A61K39/12 , C12N7/00 , A61K9/00 , A61K39/39 , A61K9/107 , A61K39/00
CPC分类号: A61K39/155 , A61K9/0019 , A61K9/1075 , A61K39/00 , A61K39/12 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , A61K2039/57 , A61K2039/575 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2760/18522 , C12N2760/18523 , C12N2760/18534 , C12N2760/18562 , C12N2760/18571
摘要: The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.
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公开(公告)号:US09675685B2
公开(公告)日:2017-06-13
申请号:US14221675
申请日:2014-03-21
申请人: NOVAVAX, INC.
发明人: Peter Pushko , Yingyun Wu , Michael J. Massare , Ye Liu , Gale Smith , Bin Zhou
IPC分类号: C07K14/05 , A61K39/155 , C07K14/005 , A61K39/12 , C12N7/00 , A61K9/00 , A61K39/39 , A61K9/107 , A61K39/00
CPC分类号: A61K39/155 , A61K9/0019 , A61K9/1075 , A61K39/00 , A61K39/12 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , A61K2039/57 , A61K2039/575 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2760/18522 , C12N2760/18523 , C12N2760/18534 , C12N2760/18562 , C12N2760/18571
摘要: The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.
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