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公开(公告)号：US06406886B1
公开(公告)日：2002-06-18
申请号：US08895810
申请日：1997-07-17
IPC分类号： C12N1512
CPC分类号： C07K16/18 , C07K14/4738
摘要： A cell division mechanism controlling protein which is not expressed in the interphase but is expressed in the nucleus after entering into a cell cycle, in the cell cycle of mammalian cell, and fragments thereof, as well as DNAs coding for said protein or fragments thereof, as well as antibodies against said protein or fragment thereof.
摘要翻译： 控制蛋白质的细胞分裂机制，其在进入细胞周期后，在哺乳动物细胞的细胞周期及其片段以及编码所述蛋白质或其片段的DNA中在间期不表达但在细胞核中表达， 以及针对所述蛋白质或其片段的抗体。
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公开(公告)号：US5998585A
公开(公告)日：1999-12-07
申请号：US895628
申请日：1997-07-17
CPC分类号： C07K16/18 , C07K14/4738
摘要： A cell division mechanism controlling protein which is not expressed during interphase but is expressed in the nucleus after entering into a cell cycle, in the cell cycle of mammalian cell, and fragments thereof, as well as DNAs coding for this protein or fragments thereof, as well as antibodies against this protein or fragment thereof.
摘要翻译： 控制蛋白质的细胞分裂机制，其在间期期间不表达，但在进入细胞周期后，在哺乳动物细胞的细胞周期及其片段中在细胞核中表达，以及编码该蛋白质或其片段的DNA作为 以及针对该蛋白质或其片段的抗体。
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公开(公告)号：US5831024A
公开(公告)日：1998-11-03
申请号：US380403
申请日：1995-01-30
CPC分类号： C07K16/18 , C07K14/4738
摘要： A cell division mechanism controlling protein which is not expressed during interphase but is expressed in the nucleus after entering into the cell cycle of a mammalian cell, fragments thereof, as well as DNAs coding for said protein or fragments thereof, as well as antibodies against said protein or fragment thereof.
摘要翻译： 控制蛋白质的细胞分裂机制，其在进入哺乳动物细胞的细胞周期之后在细胞核内表达但在细胞核内表达，其片段以及编码所述蛋白质或其片段的DNA以及抗所述蛋白质的抗体 蛋白质或其片段。
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公开(公告)号：US08362223B2
公开(公告)日：2013-01-29
申请号：US12253506
申请日：2008-10-17
申请人： Masatsugu Maeda , Noriko Yaguchi
发明人： Masatsugu Maeda , Noriko Yaguchi
CPC分类号： C07K14/705 , A61K38/00 , C07K14/715 , C07K2319/00
摘要： The inventors succeeded in isolating a novel hemopoietin receptor gene (NR10) using a sequence predicted from the extracted motif conserved in the amino acid sequences of known hemopoietin receptors. It was expected that two forms of NR10 exists, a transmembrane type and soluble form. Expression of the former type was detected in tissues containing hematopoietic cells. Thus, NR10 is a novel hemopoietin receptor molecule implicated in the regulation of the immune system and hematopoiesis in vivo. These novel receptors are useful in screening for novel hematopoietic factors capable of functionally binding to the receptor, or developing medicines to treat diseases related with the immune system or hematopoietic system.
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公开(公告)号：US08017731B2
公开(公告)日：2011-09-13
申请号：US11980117
申请日：2007-10-30
申请人： Masatsugu Maeda , Noriko Yaguchi
发明人： Masatsugu Maeda , Noriko Yaguchi
CPC分类号： C07K14/705 , A61K38/00 , C07K14/715 , C07K2319/00
摘要： The inventors succeeded in isolating a novel hemopoietin receptor gene (NR10) using a sequence predicted from the extracted motif conserved in the amino acid sequences of known hemopoietin receptors. It was expected that two forms of NR10 exists, a transmembrane type and soluble form. Expression of the former type was detected in tissues containing hematopoietic cells. Thus, NR10 is a novel hemopoietin receptor molecule implicated in the regulation of the immune system and hematopoiesis in vivo. These novel receptors are useful in screening for novel hematopoietic factors capable of functionally binding to the receptor, or developing medicines to treat diseases related with the immune system or hematopoietic system.
摘要翻译： 本发明人使用从已知的血细胞生成素受体的氨基酸序列中保存的提取的基序预测的序列成功地分离新的造血素受体基因（NR10）。 预期存在两种形式的NR10，跨膜型和可溶形式。 在含有造血细胞的组织中检测到前者的表达。 因此，NR10是一种涉及免疫系统调节和体内造血功能的新型促生长素受体分子。 这些新型受体可用于筛选能够与受体功能性结合的新型造血因子，或开发用于治疗与免疫系统或造血系统相关的疾病的药物。
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公开(公告)号：US20090023660A1
公开(公告)日：2009-01-22
申请号：US12205799
申请日：2008-09-05
申请人： Masatsugu Maeda , Noriko Yaguchi
发明人： Masatsugu Maeda , Noriko Yaguchi
CPC分类号： C07K16/2866 , C07K14/715
摘要： A novel hemopoietin receptor gene (NR12) was successfully isolated by extracting motifs conserved among the amino acid sequences of known hemopoietin receptors and by using the predicted sequence. The NR12 gene encodes two forms of proteins, a transmembrane type and a soluble type. The expression of the NR12 gene was detected in tissues containing hematopoietic cells. NR12 is a novel hemopoietin receptor molecule involved in the regulation of immune system and hematopoiesis in vivo. Thus, NR12 is useful in the search for novel hematopoietic factors that functionally bind to the NR12 receptor, and in the development of therapeutic drugs for diseases associated with immunity or hematopoiesis.
摘要翻译： 通过提取已知造血素受体的氨基酸序列中保守的基序并使用预测序列，成功分离了一种新型的生产生殖素受体基因（NR12）。 NR12基因编码两种形式的蛋白质，跨膜型和可溶型。 在含有造血细胞的组织中检测到NR12基因的表达。 NR12是一种参与体内免疫系统和造血作用调控的新型促血细胞生成素受体分子。 因此，NR12可用于寻找与NR12受体功能性结合的新型造血因子，以及用于开发与免疫或造血相关疾病的治疗药物。
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公开(公告)号：US08017738B2
公开(公告)日：2011-09-13
申请号：US11980135
申请日：2007-10-30
申请人： Masatsugu Maeda , Noriko Yaguchi
发明人： Masatsugu Maeda , Noriko Yaguchi
CPC分类号： C07K14/705 , A61K38/00 , C07K14/715 , C07K2319/00
摘要： The inventors succeeded in isolating a novel hemopoietin receptor gene (NR10) using a sequence predicted from the extracted motif conserved in the amino acid sequences of known hemopoietin receptors. It was expected that two forms of NR10 exists, a transmembrane type and soluble form. Expression of the former type was detected in tissues containing hematopoietic cells. Thus, NR10 is a novel hemopoietin receptor molecule implicated in the regulation of the immune system and hematopoiesis in vivo. These novel receptors are useful in screening for novel hematopoietic factors capable of functionally binding to the receptor, or developing medicines to treat diseases related with the immune system or hematopoietic system.
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公开(公告)号：US20090105458A1
公开(公告)日：2009-04-23
申请号：US12325617
申请日：2008-12-01
申请人： Masatsugu Maeda , Noriko Yaguchi
发明人： Masatsugu Maeda , Noriko Yaguchi
IPC分类号： C07K16/00
CPC分类号： C07K16/2866 , C07K14/715
摘要： A novel hemopoietin receptor gene (NR12) was successfully isolated by extracting motifs conserved among the amino acid sequences of known hemopoietin receptors and by using the predicted sequence. The NR12 gene encodes two forms of proteins, a transmembrane type and a soluble type. The expression of the NR12 gene was detected in tissues containing hematopoietic cells. NR12 is a novel hemopoietin receptor molecule involved in the regulation of immune system and hematopoiesis in vivo. Thus, NR12 is useful in the search for novel hematopoietic factors that functionally bind to the NR12 receptor, and in the development of therapeutic drugs for diseases associated with immunity or hematopoiesis.
摘要翻译： 通过提取已知造血素受体的氨基酸序列中保守的基序并使用预测序列，成功分离了一种新型的生产生殖素受体基因（NR12）。 NR12基因编码两种形式的蛋白质，跨膜型和可溶型。 在含有造血细胞的组织中检测到NR12基因的表达。 NR12是一种参与体内免疫系统和造血作用调控的新型促血细胞生成素受体分子。 因此，NR12可用于寻找与NR12受体功能性结合的新型造血因子，以及用于开发与免疫或造血相关疾病的治疗药物。
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公开(公告)号：US07482440B2
公开(公告)日：2009-01-27
申请号：US10006265
申请日：2001-12-03
申请人： Masatsugu Maeda , Noriko Yaguchi
发明人： Masatsugu Maeda , Noriko Yaguchi
CPC分类号： C07K14/705 , A61K38/00 , C07K14/715 , C07K2319/00
摘要： The inventors succeeded in isolating a novel hemopoietin receptor gene (NR10) using a sequence predicted from the extracted motif conserved in the amino acid sequences of known hemopoietin receptors. It was expected that two forms of NR10 exists, a transmembrane type and soluble form. Expression of the former type was detected in tissues containing hematopoietic cells. Thus, NR10 is a novel hemopoietin receptor molecule implicated in the regulation of the immune system and hematopoiesis in vivo. These novel receptors are useful in screening for novel hematopoietic factors capable of functionally binding to the receptor, or developing medicines to treat diseases related with the immune system or hematopoietic system.
摘要翻译： 本发明人使用从已知的血细胞生成素受体的氨基酸序列中保存的提取的基序预测的序列成功地分离新的造血素受体基因（NR10）。 预期存在两种形式的NR10，跨膜型和可溶形式。 在含有造血细胞的组织中检测到前者的表达。 因此，NR10是一种涉及免疫系统调节和体内造血功能的新型促生长素受体分子。 这些新型受体可用于筛选能够与受体功能性结合的新型造血因子，或开发用于治疗与免疫系统或造血系统相关的疾病的药物。
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公开(公告)号：US07220828B2
公开(公告)日：2007-05-22
申请号：US09037657
申请日：1998-03-10
申请人： Tracy Willson , Nicos A. Nicola , Douglas J. Hilton , Jian-Guo Zhang , Alison Farley , Warren Alexander , Steven Rakar , Yasufumi Kikuchi , Tetsuo Kojima , Masatsugu Maeda , Louis Fabri , Andrew Nash
发明人： Tracy Willson , Nicos A. Nicola , Douglas J. Hilton , Jian-Guo Zhang , Alison Farley , Warren Alexander , Steven Rakar , Yasufumi Kikuchi , Tetsuo Kojima , Masatsugu Maeda , Louis Fabri , Andrew Nash
IPC分类号： C07K14/715 , C12N15/09 , A61K38/00
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00
摘要： The present invention relates generally to a novel haemopoietin receptor or derivatives thereof and to genetic sequences encoding same. Interaction between the novel receptor of the present invention and a cytokine ligand facilitates proliferation, differentiation and survival of a wide variety of cells. The novel receptor and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor.
摘要翻译： 本发明一般涉及一种新型促血细胞生成素受体或其衍生物和编码该基因的遗传序列。 本发明的新型受体与细胞因子配体之间的相互作用促进多种细胞的增殖，分化和存活。 本发明的新受体及其衍生物和编码本发明的遗传序列可用于开发基于配体与其受体相互作用的广泛范围的激动剂，拮抗剂，治疗剂和诊断试剂。
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