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公开(公告)号：US6153397A
公开(公告)日：2000-11-28
申请号：US471528
申请日：1999-12-27
摘要： The present invention relates to arthropod epoxide hydrolase proteins; to arthropod epoxide hydrolase nucleic acid molecules, including those that encode such epoxide hydrolase proteins; to antibodies raised against such epoxide hydrolase proteins; and to other compounds that inhibit arthropod epoxide hydrolase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
摘要翻译： 本发明涉及节肢动物环氧化物水解酶蛋白质; 包括那些编码这种环氧化物水解酶蛋白质的节肢动物环氧化物水解酶核酸分子; 针对这种环氧化物水解酶蛋白产生的抗体; 以及抑制节肢动物环氧化物水解酶活性的其他化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及使用这种治疗组合物来保护动物免受血液节肢动物侵袭。
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公开(公告)号：US06290958B1
公开(公告)日：2001-09-18
申请号：US09634530
申请日：2000-08-08
IPC分类号： A61K39395
摘要： The present invention relates to arthropod epoxide hydrolase proteins; to arthropod epoxide hydrolase nucleic acid molecules, including those that encode such epoxide hydrolase proteins; to antibodies raised against such epoxide hydrolase proteins; and to other compounds that inhibit arthropod epoxide hydrolase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
摘要翻译： 本发明涉及节肢动物环氧化物水解酶蛋白质; 包括那些编码这种环氧化物水解酶蛋白质的节肢动物环氧化物水解酶核酸分子; 针对这种环氧化物水解酶蛋白产生的抗体; 以及抑制节肢动物环氧化物水解酶活性的其他化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及使用这些治疗组合物来保护动物免受血液节肢动物侵袭。
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3.发明授权
公开(公告)号：US6143542A
公开(公告)日：2000-11-07
申请号：US182816
申请日：1998-10-29
摘要： The present invention relates to arthropod epoxide hydrolase proteins; to arthropod epoxide hydrolase nucleic acid molecules, including those that encode such epoxide hydrolase proteins; to antibodies raised against such epoxide hydrolase proteins; and to other compounds that inhibit arthropod epoxide hydrolase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
摘要翻译： 本发明涉及节肢动物环氧化物水解酶蛋白质; 包括那些编码这种环氧化物水解酶蛋白质的节肢动物环氧化物水解酶核酸分子; 针对这种环氧化物水解酶蛋白产生的抗体; 以及抑制节肢动物环氧化物水解酶活性的其他化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及使用这些治疗组合物来保护动物免受血液节肢动物侵袭。
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公开(公告)号：US6037160A
公开(公告)日：2000-03-14
申请号：US989510
申请日：1997-12-12
摘要： The present invention relates to arthropod epoxide hydrolase proteins; to arthropod epoxide hydrolase nucleic acid molecules, including those that encode such epoxide hydrolase proteins; to antibodies raised against such epoxide hydrolase proteins; and to other compounds that inhibit arthropod epoxide hydrolase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
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5.发明申请公开(公告)号：US20090170146A1
公开(公告)日：2009-07-02
申请号：US12013262
申请日：2008-01-11
申请人： Gary M. Silver , Nancy Wisnewski , Kevin S. Brandt
发明人： Gary M. Silver , Nancy Wisnewski , Kevin S. Brandt
摘要： The present invention relates to arthropod esterase proteins; to arthropod esterase nucleic acid molecules, including those that encode such esterase proteins; to antibodies raised against such esterase proteins; and to other compounds that inhibit arthropod esterase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
摘要翻译： 本发明涉及节肢动物酯酶蛋白质; 包括那些编码这种酯酶蛋白质的节肢动物酯酶核酸分子; 针对这种酯酶蛋白产生的抗体; 以及抑制节肢动物酯酶活性的其他化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及使用这些治疗组合物来保护动物免受血液节肢动物侵袭。
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公开(公告)号：US06664090B1
公开(公告)日：2003-12-16
申请号：US09403942
申请日：2000-05-02
申请人： Gary M. Silver , Nancy Wisnewski , Kevin S. Brandt
发明人： Gary M. Silver , Nancy Wisnewski , Kevin S. Brandt
IPC分类号： C12N918
摘要： The present invention relates to arthropod esterase proteins; to arthropod esterase nucleic acid molecules, including those that encode such esterase proteins; to antibodies raised against such esterase proteins; and to other compounds that inhibit arthropod esterase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
摘要翻译： 本发明涉及节肢动物酯酶蛋白质; 包括那些编码这种酯酶蛋白质的节肢动物酯酶核酸分子; 针对这种酯酶蛋白产生的抗体; 以及抑制节肢动物酯酶活性的其他化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及使用这些治疗组合物来保护动物免受血液节肢动物侵袭。
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7.发明授权Parasitic helminth macrophage migration inhibitory factor proteins, nucleic acid molecules, and uses thereof 失效寄生虫蠕虫巨噬细胞迁移抑制因子蛋白质，核酸分子及其用途公开(公告)号：US06207158B1
公开(公告)日：2001-03-27
申请号：US08906480
申请日：1997-08-05
IPC分类号： A61K3900
CPC分类号： H01G9/055 , C07K14/52 , C07K2319/00 , Y10S435/975
摘要： The present invention relates to parasitic helminth macrophage migration inhibitory factor (MIF) proteins; to parasitic helminth MIF nucleic acid molecules, including those that encode such MIF proteins; to antibodies raised against such MIF proteins; and to compounds that inhibit parasitic helminth MIF activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译： 本发明涉及寄生蠕虫巨噬细胞迁移抑制因子（MIF）蛋白; 包括那些编码这种MIF蛋白的MIF核酸分子， 针对这种MIF蛋白产生的抗体; 以及抑制寄生蠕虫MIF活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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公开(公告)号：US07476728B2
公开(公告)日：2009-01-13
申请号：US10433140
申请日：2002-11-21
申请人： Nancy Wisnewski , Kevin S. Brandt
发明人： Nancy Wisnewski , Kevin S. Brandt
IPC分类号： C07H21/02
CPC分类号： C07K14/705 , A61K38/00 , G01N2500/04
摘要： The present invention relates to flea GABA receptor subunit nucleic acid molecules; to flea GABA receptor subunit proteins encoded by such nucleic acid molecules; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and inhibitory compounds, particularly those that specifically inhibit flea GABA receptor subunit activity, as well as the use of such therapeutic compositions to treat animals.
摘要翻译： 本发明涉及跳蚤GABA受体亚基核酸分子; 由这种核酸分子编码的跳蚤GABA受体亚基蛋白; 针对这种蛋白质产生的抗体; 以及抑制这些蛋白质活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和抑制性化合物，特别是那些特异性抑制跳蚤GABA受体亚基活性的化合物的治疗组合物，以及这些治疗组合物用于治疗动物的治疗组合物。
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9.发明授权Flea head, nerve cord, hindgut and malpighian tubule nucleic acid molecules, proteins and uses thereof 有权跳蚤头，神经线，后肠和恶臭小管核酸分子，蛋白质及其用途公开(公告)号：US08088903B2
公开(公告)日：2012-01-03
申请号：US11565729
申请日：2006-12-01
CPC分类号： C07K14/4359
摘要： The present invention relates to flea head, nerve cord, hindgut and Malpighian tubule proteins; to flea head, nerve cord, hindgut and Malpighian tubule nucleic acid molecules, including those that encode such flea head, nerve cord, hindgut and Malpighian tubule proteins; to antibodies raised against such flea head, nerve cord, hindgut and Malpighian tubule proteins; and to compounds that inhibit flea head, nerve cord, hindgut and Malpighian tubule protein activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising proteins, nucleic acid molecules, antibodies, or protective compounds derived from proteins of the present invention as well as the use of such therapeutic compositions to protect animals from flea infestation. Also included in the present invention is the use of flea head, nerve cord, hindgut and Malpighian tubule proteins to derive inhibitory compounds.
摘要翻译： 本发明涉及跳蚤头，神经根，后肠和马鞭状小管蛋白; 跳蚤头，神经线，后肠和马鞭状小管核酸分子，包括编码这种跳蚤头，神经线，后肠和马鞭状小管蛋白的那些; 针对这种跳蚤头，神经线，后肠和马鞭状小管蛋白质产生的抗体; 以及抑制跳蚤头，神经丝，后肠和马鞭状小管蛋白活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含衍生自本发明蛋白质的蛋白质，核酸分子，抗体或保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。 本发明还包括使用跳蚤头，神经根，后肠和马鞭状小管蛋白来衍生抑制性化合物。
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公开(公告)号：US06638744B2
公开(公告)日：2003-10-28
申请号：US09919060
申请日：2001-07-31
申请人： Nancy Wisnewski , Kevin S. Brandt
发明人： Nancy Wisnewski , Kevin S. Brandt
IPC分类号： C12N902
CPC分类号： A61K31/7088 , C12N9/90
摘要： The present invention relates to canine COX-1 and COX-2 proteins; to canine COX-1 and COX-2 nucleic acid molecules, including those that encode such COX-1 and COX-2 proteins, respectively; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit COX-2 activity, as well as the use of such therapeutic compositions to treat animals.
摘要翻译： 本发明涉及犬COX-1和COX-2蛋白; 涉及犬COX-1和COX-2核酸分子，包括分别编码这种COX-1和COX-2蛋白的那些; 针对这种蛋白质产生的抗体; 以及抑制这些蛋白质活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这种抑制性化合物，特别是特异性抑制COX-2活性的抑制性化合物的治疗组合物，以及这些治疗组合物用于治疗动物的用途。
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