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1.发明授权公开(公告)号：US06365392B1
公开(公告)日：2002-04-02
申请号：US09005298
申请日：1998-01-09
IPC分类号： C12N701
CPC分类号： G01N33/5091 , A61K38/00 , A61K39/00 , A61K39/0003 , A61K2039/51 , C07K14/4354 , C07K16/18 , C07K16/40 , C07K2319/00 , C12N9/6402 , C12N9/641 , C12N2799/021 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/5308 , G01N33/56905 , G01N2333/4353 , G01N2333/95 , G01N2333/96402 , Y02A50/422
摘要： The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
摘要翻译： 本发明提供丝状线虫半胱氨酸蛋白酶蛋白; 丝丝虫线虫半胱氨酸蛋白酶核酸分子，特别是id ia is is is val val val val val val val ysteine;;;;;;;;;;;;;;;;;;;; 针对这种蛋白质产生的抗体，以及抑制丝状线虫半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和/或抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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公开(公告)号：US6114142A
公开(公告)日：2000-09-05
申请号：US473034
申请日：1995-06-06
CPC分类号： C07K14/4354 , C07K16/20
摘要： The present invention relates to parasitic helminth proteins of about 39 kD (i.e., P39 proteins); to parasitic helminth P39 nucleic acid molecules, including those that encode such proteins; and to antibodies raised against such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, and antibodies. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, and/or antibodies as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译： 本发明涉及约39kD（即P39蛋白）的寄生蠕虫蛋白; 包括寄生蠕虫P39核酸分子，包括编码这些蛋白质的那些; 以及针对这种蛋白质产生的抗体。 本发明还包括获得这些蛋白质，核酸分子和抗体的方法。 本发明还包括包含这些蛋白质，核酸分子和/或抗体的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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公开(公告)号：US6100390A
公开(公告)日：2000-08-08
申请号：US458860
申请日：1995-06-02
IPC分类号： C12N15/09 , A61K31/70 , A61K35/12 , A61K35/68 , A61K38/00 , A61K38/08 , A61K38/17 , A61K39/00 , A61K39/395 , A61P33/00 , C07H21/04 , C07K14/435 , C07K16/18 , C12N5/00 , C12N5/10 , C12N9/64 , C12N15/12 , C12N15/63 , C12P21/02 , C12P21/04 , C12P21/08 , C12R1/91 , G01N33/50 , G01N33/53 , G01N33/569 , C07H21/02 , C12P21/06 , C12P71/04
CPC分类号： G01N33/56905 , A61K39/0003 , A61K39/39533 , C07K14/4354 , C07K16/18 , C12N9/641 , G01N33/5008 , G01N33/5014 , G01N33/5088 , G01N33/5091 , G01N33/5308 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2799/021 , G01N2333/4353 , G01N2333/95 , G01N2333/96402
摘要： The present invention relates to isolated parasitic helminth nucleic acid sequences capable of hybridizing, under stringent conditions, to at least a portion of D. immitis nucleic acid sequence p4 and/or to at least a portion of D. immitis nucleic acid sequence p22U; to isolated parasitic helminth proteins that are encoded by such parasitic helminth nucleic acid sequences and that are capable of selectively binding to at least one component of immune serum capable of inhibiting helminth development; and to antibodies raised against such isolated parasitic helminth proteins. The present invention also relates to therapeutic compositions comprising such isolated nucleic acid sequences, proteins and/or antibodies. The present invention also includes methods to produce and use such nucleic acids, proteins, antibodies and therapeutic compositions capable of protecting animals from parasitic helminth infection and, particularly, from heartworm infection.
摘要翻译： 本发明涉及分离的寄生蠕虫核酸序列，其能够在严格条件下与至少一部分核酸核酸序列p4和/或至少部分核型核酸序列p22U杂交; 至由这种寄生蠕虫核酸序列编码并且能够选择性结合能够抑制蠕虫发育的至少一种免疫血清成分的分离的寄生蠕虫蛋白; 以及针对这种分离的寄生蠕虫蛋白产生的抗体。 本发明还涉及包含这种分离的核酸序列，蛋白质和/或抗体的治疗组合物。 本发明还包括生产和使用能够保护动物免受寄生蠕虫感染，特别是来自心丝虫感染的核酸，蛋白质，抗体和治疗组合物的方法。
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4.发明授权Parasitic helminth larval thiol specific antioxidant proteins, nucleic acid molecules and uses thereof 失效寄生虫丝虫幼虫硫醇特异性抗氧化蛋白，核酸分子及其用途
公开(公告)号：US6031077A
公开(公告)日：2000-02-29
申请号：US4716
申请日：1998-01-07
申请人： Laura Klimowski , Cynthia Ann Tripp
发明人： Laura Klimowski , Cynthia Ann Tripp
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K39/002 , A61K39/395 , A61K45/00 , A61P33/00 , A61P33/02 , C07K14/435 , C07K14/44 , C07K16/18 , C07K16/20 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/569 , C07K1/00 , A01N43/04 , A61K38/16 , A61K39/00 , A61K39/02
CPC分类号： C07K14/43536 , C07K14/4354 , C07K16/18 , A61K38/00 , C07K2319/00 , C12N2799/023
摘要： The present invention relates to parasitic helminth thiol specific antioxidant (TSA) larval proteins; to parasitic helminth larval TSA nucleic acid molecules, including those that encode such TSA proteins; to antibodies raised against such TSA proteins; and to compounds that inhibit parasitic helminth larval TSA activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译： 本发明涉及寄生蠕虫硫醇特异性抗氧化剂（TSA）幼虫蛋白质; 寄生虫寄生虫幼虫TSA核酸分子，包括编码这种TSA蛋白的那些; 针对这种TSA蛋白产生的抗体; 以及抑制寄生蠕虫幼虫TSA活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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公开(公告)号：US5977306A
公开(公告)日：1999-11-02
申请号：US487031
申请日：1995-06-06
CPC分类号： A61K38/27 , G01N33/5308 , G01N33/56905 , C12N2799/021
摘要： The present invention relates to parasitic helminth proteins of about 39 kD (i.e., P39 proteins); to parasitic helminth P39 nucleic acid molecules, including those that encode such proteins; and to antibodies raised against such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, and antibodies. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, and/or antibodies as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译： 本发明涉及约39kD（即P39蛋白）的寄生蠕虫蛋白; 包括寄生蠕虫P39核酸分子，包括编码这些蛋白质的那些; 以及针对这种蛋白质产生的抗体。 本发明还包括获得这些蛋白质，核酸分子和抗体的方法。 本发明还包括包含这些蛋白质，核酸分子和/或抗体的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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6.发明授权Filariid nematode cysteine protease proteins, nucleic acid molecules and uses thereof 失效丝状线虫半胱氨酸蛋白酶蛋白，核酸分子及其用途
公开(公告)号：US5795768A
公开(公告)日：1998-08-18
申请号：US486036
申请日：1995-06-07
IPC分类号： C12N15/09 , A61K35/68 , A61K38/00 , A61K38/46 , A61K38/55 , A61K39/00 , A61K39/395 , A61K48/00 , A61P33/00 , C07K14/435 , C07K16/18 , C07K16/40 , C12N7/00 , C12N9/64 , C12N15/57 , C12Q1/37 , G01N33/50 , G01N33/53 , G01N33/569 , C12N1/20
CPC分类号： C12N9/641 , A61K39/0003 , C07K14/4354 , C07K16/18 , C07K16/40 , C12N9/6402 , G01N33/5008 , G01N33/5091 , G01N33/5308 , G01N33/56905 , A61K2039/51 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2799/021 , G01N2333/4353 , G01N2333/95 , G01N2333/96402
摘要： The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
摘要翻译： 本发明提供丝状线虫半胱氨酸蛋白酶蛋白; 丝丝虫线虫半胱氨酸蛋白酶核酸分子，特别是id ia is is is val val val val val val val ysteine;;;;;;;;;;;;;;;;;;;; 针对这种蛋白质产生的抗体，以及抑制丝状线虫半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和/或抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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7.发明授权Dirofilaria and onchocerca larval L3 cysteine protease proteins and uses thereof 失效Dirofilaria和onchocerca幼虫L3半胱氨酸蛋白酶蛋白及其用途
公开(公告)号：US5792624A
公开(公告)日：1998-08-11
申请号：US482282
申请日：1995-06-07
IPC分类号： A61K38/00 , A61K39/00 , C07K14/435 , C07K16/18 , C07K16/40 , C12N9/64 , G01N33/50 , G01N33/53 , G01N33/569 , C12P21/06 , C12N15/00 , C12P21/04
CPC分类号： G01N33/5091 , A61K39/0003 , C07K14/4354 , C07K16/18 , C07K16/40 , C12N9/6402 , C12N9/641 , G01N33/5008 , G01N33/5308 , G01N33/56905 , A61K2039/51 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2799/021 , G01N2333/4353 , G01N2333/95 , G01N2333/96402
摘要： The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
摘要翻译： 本发明提供丝状线虫半胱氨酸蛋白酶蛋白; 丝丝虫线虫半胱氨酸蛋白酶核酸分子，特别是id ia is is is val val val val val val val ysteine;;;;;;;;;;;;;;;;;;;; 针对这种蛋白质产生的抗体，以及抑制丝状线虫半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和/或抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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8.发明授权Parasitic helminth macrophage migration inhibitory factor proteins, nucleic acid molecules, and uses thereof 失效寄生虫蠕虫巨噬细胞迁移抑制因子蛋白质，核酸分子及其用途公开(公告)号：US06207158B1
公开(公告)日：2001-03-27
申请号：US08906480
申请日：1997-08-05
IPC分类号： A61K3900
CPC分类号： H01G9/055 , C07K14/52 , C07K2319/00 , Y10S435/975
摘要： The present invention relates to parasitic helminth macrophage migration inhibitory factor (MIF) proteins; to parasitic helminth MIF nucleic acid molecules, including those that encode such MIF proteins; to antibodies raised against such MIF proteins; and to compounds that inhibit parasitic helminth MIF activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译： 本发明涉及寄生蠕虫巨噬细胞迁移抑制因子（MIF）蛋白; 包括那些编码这种MIF蛋白的MIF核酸分子， 针对这种MIF蛋白产生的抗体; 以及抑制寄生蠕虫MIF活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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公开(公告)号：US5912337A
公开(公告)日：1999-06-15
申请号：US460428
申请日：1995-06-02
IPC分类号： C12N15/09 , A61K31/70 , A61K35/12 , A61K35/68 , A61K38/00 , A61K38/08 , A61K38/17 , A61K39/00 , A61K39/395 , A61P33/00 , C07H21/04 , C07K14/435 , C07K16/18 , C12N5/00 , C12N5/10 , C12N9/64 , C12N15/12 , C12N15/63 , C12P21/02 , C12P21/04 , C12P21/08 , C12R1/91 , G01N33/50 , G01N33/53 , G01N33/569
CPC分类号： G01N33/56905 , A61K39/0003 , A61K39/39533 , C07K14/4354 , C07K16/18 , C12N9/641 , G01N33/5008 , G01N33/5014 , G01N33/5088 , G01N33/5091 , G01N33/5308 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2799/021 , G01N2333/4353 , G01N2333/95 , G01N2333/96402
摘要： The present invention relates to an isolated protein comprising a filariid p22U protein. In a preferred embodiment, the filariid p22U protein selectively binds to immune serum which is derived from an animal that is immune to infection by Dirofilaria immitis. Such an animal can be immunized with a composition comprising third and/or fourth stage Dirofilaria immitis larvae. In a preferred embodiment, the filariid p22U protein is a Dirofilaria protein.
摘要翻译： 本发明涉及包含丝状p22U蛋白的分离蛋白。 在优选的实施方案中，丝状p22U蛋白选择性地结合免疫血清，所述免疫血清来源于免疫于疟原虫感染的动物。 这样的动物可以用包含第三和/或第四阶段疟原虫幼虫的组合物免疫。 在优选的实施方案中，丝状蛋白p22U蛋白是二鞭毛蛋白。
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公开(公告)号：US5789194A
公开(公告)日：1998-08-04
申请号：US450944
申请日：1995-05-23
申请人： Cynthia Ann Tripp , Nancy Wisnewski
发明人： Cynthia Ann Tripp , Nancy Wisnewski
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K39/00 , A61K48/00 , A61P33/00 , C07K14/435 , C07K14/44 , C07K16/18 , C07K16/20 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N7/00 , C12P21/02 , C12P21/00 , C07H21/04 , C07K1/00
CPC分类号： C07K16/18 , C07K14/4354 , A61K38/00 , A61K39/00
摘要： The present invention relates to parasitic helminth venom allergen antigen 5-like proteins; to parasitic helminth venom allergen antigen 5-like nucleic acid molecules, including those that encode such proteins; and to antibodies raised against such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules and antibodies. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules and/or antibodies, as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译： 本发明涉及寄生蠕虫毒液变应原抗原5样蛋白; 对寄生蠕虫毒素变应原抗原5样核酸分子，包括编码这些蛋白质的那些; 以及针对这种蛋白质产生的抗体。 本发明还包括获得这些蛋白质，核酸分子和抗体的方法。 本发明还包括包含这些蛋白质，核酸分子和/或抗体的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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