公开(公告)号：US20040089057A1

公开(公告)日：2004-05-13

申请号：US10699533

申请日：2003-10-30

Applicant: Nanostream, Inc.

Inventor： Steven E. Hobbs ,  Hau H. Duong

IPC: G01N030/74

CPC classification number: G01N30/466 ,  G01N30/6026 ,  G01N30/6047 ,  G01N30/6091 ,  G01N30/6095 ,  G01N30/74 ,  G01N2030/746 ,  G01N2030/8881

Abstract: High throughput liquid chromatography systems include multiple separation columns and multiple flow-through detection regions in sensory communication with a common radiation source and a multi-channel detector. Preferred detector types include a multi-anode photomultiplier tube, a charge-coupled device detector, a diode array, and a photodiode array. In certain embodiments, separation columns are microfluidic and integrated into a unitary microfluidic device. The optical path through a detection region is preferably coaxial with the path of eluate flow along a flow axis through a detection region. On-board or off-board detection regions may be provided.

Abstract translation: 高通量液相色谱系统包括多个分离柱和与普通辐射源和多通道检测器的感觉通信中的多个流通检测区域。 优选的检测器类型包括多阳极光电倍增管，电荷耦合器件检测器，二极管阵列和光电二极管阵列。 在某些实施方案中，分离柱是微流体并且整合成单一微流体装置。 通过检测区域的光路优选地与通过检测区域的流动轴的洗脱液流的路径同轴。 可以提供车载或车外检测区域。

公开(公告)号：US20040089607A1

公开(公告)日：2004-05-13

申请号：US10696354

申请日：2003-10-28

Applicant: Nanostream, Inc.

Inventor： Steven E. Hobbs ,  Hau H. Duong ,  Scott G. Beach

IPC: B01D015/08

CPC classification number: G01N30/466 ,  G01N30/6026 ,  G01N30/6047 ,  G01N30/6095 ,  G01N30/74 ,  G01N2030/746 ,  G01N2030/8881

Abstract: Systems and methods for performing multiple parallel chromatographic separations are provided. Microfluidic cartridges containing multiple separation columns allow multiple separations to be performed in a limited space by a single instrument containing high-pressure pumps and analyte detectors. The use of pressure fit interfaces allows the microfluidic cartridges to easily be removed and replaced within the instrument, either manually or robotically.

Abstract translation: 提供了执行多个并行色谱分离的系统和方法。 含有多个分离柱的微流控筒可以通过含有高压泵和分析物检测器的单个仪器在有限的空间内进行多次分离。 压力接合界面的使用允许微流控盒容易地在仪器内被手动或机器人移除和更换。