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11 条记录 (耗时 0.017 秒)

    Parallel detection chromatography systems
    1.
    发明申请
    Parallel detection chromatography systems 有权
    并行检测色谱系统

    公开(公告)号：US20040089057A1

    公开(公告)日：2004-05-13

    申请号：US10699533

    申请日：2003-10-30

    申请人： Nanostream, Inc.

    发明人： Steven E. Hobbs ,  Hau H. Duong

    IPC分类号： G01N030/74

    CPC分类号： G01N30/466 ,  G01N30/6026 ,  G01N30/6047 ,  G01N30/6091 ,  G01N30/6095 ,  G01N30/74 ,  G01N2030/746 ,  G01N2030/8881

    摘要： High throughput liquid chromatography systems include multiple separation columns and multiple flow-through detection regions in sensory communication with a common radiation source and a multi-channel detector. Preferred detector types include a multi-anode photomultiplier tube, a charge-coupled device detector, a diode array, and a photodiode array. In certain embodiments, separation columns are microfluidic and integrated into a unitary microfluidic device. The optical path through a detection region is preferably coaxial with the path of eluate flow along a flow axis through a detection region. On-board or off-board detection regions may be provided.

    摘要翻译： 高通量液相色谱系统包括多个分离柱和与普通辐射源和多通道检测器的感觉通信中的多个流通检测区域。 优选的检测器类型包括多阳极光电倍增管，电荷耦合器件检测器，二极管阵列和光电二极管阵列。 在某些实施方案中，分离柱是微流体并且整合成单一微流体装置。 通过检测区域的光路优选地与通过检测区域的流动轴的洗脱液流的路径同轴。 可以提供车载或车外检测区域。

    High throughput systems and methods for parallel sample analysis
    5.
    发明申请
    High throughput systems and methods for parallel sample analysis 有权
    高通量系统和并行样本分析方法

    公开(公告)号：US20040217279A1

    公开(公告)日：2004-11-04

    申请号：US10736154

    申请日：2003-12-13

    申请人： Nanostream, Inc.

    发明人： Steven E. Hobbs ,  Stephen D. O'Connor ,  Ronald C. Gamble

    IPC分类号： H01J049/00

    CPC分类号： G01N30/6043 ,  B01L3/5027 ,  G01N30/6095 ,  G01N30/72 ,  H01J49/009 ,  H01J49/04

    摘要： Systems for analyzing multiple samples in parallel using mass spectrometric preferably coupled with fluid phase separation techniques are provided. A multi-analyzer mass spectrometer includes multiple inlets, multiple mass analyzers, and multiple transducers to conduct mass analyses of multiple samples in parallel. A modular mass analyzer may include a vacuum enclosure, a chassis, and multiple mass analysis modules disposed within the chassis. Modules are preferably disposed in a spatially compact two-dimensional array. A common multi-stage vacuum system may be utilized in conjunction with baffles or partitions disposed within and between modules to maintain differential vacuum conditions within the spectrometer utilizing a minimum number of pumps. Common control inputs may be provided to multiple modules or other components within a multi-analyzer spectrometer. Fluid phase separation devices for use with a multi-analyzer spectrometer may be microfluidic devices utilizing chromatographic, electrophoretic, or other separation methods.

    摘要翻译： 提供了使用优选与流体相分离技术耦合的质谱分析多个样品的系统。 多分析仪质谱仪包括多个入口，多个质量分析仪和多个换能器，用于并行进行多个样品的质量分析。 模块化质量分析器可以包括真空外壳，底盘以及设置在底盘内的多个质量分析模块。 模块优选地设置在空间紧凑的二维阵列中。 共同的多级真空系统可以与设置在模块内和模块之间的挡板或隔板一起使用，以利用最少数量的泵来维持光谱仪内的差分真空条件。 通常的控制输入可以提供给多分析仪光谱仪中的多个模块或其他组件。 用于多分析仪光谱仪的流体相分离装置可以是利用色谱，电泳或其它分离方法的微流体装置。

    Systems and methods for preparing microfluidic devices for operation
    7.
    发明申请
    Systems and methods for preparing microfluidic devices for operation 审中-公开
    用于制备微流控装置的系统和方法

    公开(公告)号：US20040092033A1

    公开(公告)日：2004-05-13

    申请号：US10686347

    申请日：2003-10-14

    申请人： Nanostream, Inc.

    发明人： Vincent K. Gustafson ,  Steven E. Hobbs

    IPC分类号： G01N001/10

    CPC分类号： G01N30/34 ,  B01D19/0031 ,  B01L3/5027 ,  G01N30/16 ,  G01N30/36 ,  G01N30/466 ,  G01N30/6095 ,  G01N2030/322 ,  G01N2035/1018 ,  Y10T436/2575

    摘要： Systems and method for removing undesirable gas from microfluidic separation devices to prepare them for operation are provided. The microfluidic devices contain separation media that provides a significant fluidic impedance. A vacuum source is used to evacuate gas from, and a positive pressure source is used to introduce liquid into, the microfluidic device to minimize the presence of undesirable bubbles. Where hydrophobic materials are present within the microfluidic device, the liquid may be an organic solvent. Positive pressures of at least about 100 psi are preferably employed. A microfluidic separation device may include multiple separation columns and a distribution network in fluid communication with the columns.

    摘要翻译： 提供了用于从微流体分离装置去除不需要的气体以准备它们进行操作的系统和方法。 微流体装置包含提供显着的流体阻抗的分离介质。 使用真空源从中抽出气体，使用正压源将液体引入微流体装置中以最小化不期望的气泡的存在。 在微流体装置内存在疏水性材料的情况下，液体可以是有机溶剂。 优选使用至少约100psi的正压力。 微流体分离装置可以包括多个分离柱和与柱流体连通的分配网络。

    System and method for performing multiple parallel chromatographic separations
    8.
    发明申请
    System and method for performing multiple parallel chromatographic separations 有权
    执行多个并行色谱分离的系统和方法

    公开(公告)号：US20040089607A1

    公开(公告)日：2004-05-13

    申请号：US10696354

    申请日：2003-10-28

    申请人： Nanostream, Inc.

    发明人： Steven E. Hobbs ,  Hau H. Duong ,  Scott G. Beach

    IPC分类号： B01D015/08

    CPC分类号： G01N30/466 ,  G01N30/6026 ,  G01N30/6047 ,  G01N30/6095 ,  G01N30/74 ,  G01N2030/746 ,  G01N2030/8881

    摘要： Systems and methods for performing multiple parallel chromatographic separations are provided. Microfluidic cartridges containing multiple separation columns allow multiple separations to be performed in a limited space by a single instrument containing high-pressure pumps and analyte detectors. The use of pressure fit interfaces allows the microfluidic cartridges to easily be removed and replaced within the instrument, either manually or robotically.

    摘要翻译： 提供了执行多个并行色谱分离的系统和方法。 含有多个分离柱的微流控筒可以通过含有高压泵和分析物检测器的单个仪器在有限的空间内进行多次分离。 压力接合界面的使用允许微流控盒容易地在仪器内被手动或机器人移除和更换。