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    Microfluidic flow control device with floating element
    1.
    发明申请
    Microfluidic flow control device with floating element 有权
    具有浮动元件的微流量控制装置

    公开(公告)号：US20030116738A1

    公开(公告)日：2003-06-26

    申请号：US10026380

    申请日：2001-12-20

    申请人： Nanostream, Inc.

    发明人： Stephen D. O'Connor ,  Eugene Dantsker ,  Adrian Hightower

    IPC分类号： F16K031/02

    CPC分类号： F15C5/00 ,  F16K99/0001 ,  F16K99/0011 ,  F16K99/0023 ,  F16K99/0046 ,  F16K99/0057 ,  F16K2099/0076 ,  F16K2099/008 ,  H01H2029/008 ,  Y10T137/2191

    摘要： A microfluidic flow control device includes a fluidic chamber, a first and a second microfluidic channel, at least one sealing surface between the first and the second channels, and a floating element disposed within the chamber. The floating element is capable of intermittently engaging the sealing surface, and movement of the floating element affects fluid flow between the first channel and the second channel. The floating element may be moved by fluid pressure, gravity, or an applied force such as a magnetic field. Multiple flow control regions may be integrated into a flow control system.

    摘要翻译： 微流体流量控制装置包括流体室，第一和第二微流体通道，第一和第二通道之间的至少一个密封表面，以及设置在室内的浮动元件。 浮动元件能够间歇地接合密封表面，并且浮动元件的移动影响第一通道和第二通道之间的流体流动。 浮动元件可以通过流体压力，重力或施加的力（例如磁场）移动。 多个流量控制区域可以集成到流量控制系统中。

    Parallel detection chromatography systems
    6.
    发明申请
    Parallel detection chromatography systems 有权
    并行检测色谱系统

    公开(公告)号：US20040089057A1

    公开(公告)日：2004-05-13

    申请号：US10699533

    申请日：2003-10-30

    申请人： Nanostream, Inc.

    发明人： Steven E. Hobbs ,  Hau H. Duong

    IPC分类号： G01N030/74

    CPC分类号： G01N30/466 ,  G01N30/6026 ,  G01N30/6047 ,  G01N30/6091 ,  G01N30/6095 ,  G01N30/74 ,  G01N2030/746 ,  G01N2030/8881

    摘要： High throughput liquid chromatography systems include multiple separation columns and multiple flow-through detection regions in sensory communication with a common radiation source and a multi-channel detector. Preferred detector types include a multi-anode photomultiplier tube, a charge-coupled device detector, a diode array, and a photodiode array. In certain embodiments, separation columns are microfluidic and integrated into a unitary microfluidic device. The optical path through a detection region is preferably coaxial with the path of eluate flow along a flow axis through a detection region. On-board or off-board detection regions may be provided.

    摘要翻译： 高通量液相色谱系统包括多个分离柱和与普通辐射源和多通道检测器的感觉通信中的多个流通检测区域。 优选的检测器类型包括多阳极光电倍增管，电荷耦合器件检测器，二极管阵列和光电二极管阵列。 在某些实施方案中，分离柱是微流体并且整合成单一微流体装置。 通过检测区域的光路优选地与通过检测区域的流动轴的洗脱液流的路径同轴。 可以提供车载或车外检测区域。

    Fault tolerant detection regions in microfluidic systems
    7.
    发明申请
    Fault tolerant detection regions in microfluidic systems 审中-公开
    微流体系统中的容错检测区域

    公开(公告)号：US20040018115A1

    公开(公告)日：2004-01-29

    申请号：US10207496

    申请日：2002-07-29

    申请人： Nanostream, Inc.

    发明人： Christoph D. Karp

    IPC分类号： G01N021/00

    CPC分类号： B01L3/5027 ,  B01L2200/025 ,  B01L2200/14 ,  B01L2300/0654 ,  B01L2300/0861 ,  B01L2300/0887

    摘要： Microfluidic devices including detection channel geometries that facilitate alignment such detection channels with multiple external sensors are provided. The detection channels include fault tolerant detection channels segments that have a span proportional and parallel to any anticipated positional or dimensional variation of the detection channels with respect to the positions of the multiple external sensors. The detection channels have a substantially constant channel width to minimize pressure-driven channel distortion and dead volumes.

    摘要翻译： 提供了包括检测通道几何形状的微流体装置，其便于对准具有多个外部传感器的检测通道。 检测通道包括容错检测通道段，其具有与多个外部传感器的位置成比例并且平行于检测通道的任何预期位置或尺寸变化的跨度。 检测通道具有基本恒定的通道宽度，以最小化压力驱动的通道失真和死体积。

    Pressurized microfluidic devices with optical detection regions
    9.
    发明申请
    Pressurized microfluidic devices with optical detection regions 失效
    具有光学检测区域的加压微流体装置

    公开(公告)号：US20040118189A1

    公开(公告)日：2004-06-24

    申请号：US10697923

    申请日：2003-10-29

    申请人： Nanostream, Inc.

    发明人： Christoph D. Karp ,  Paren P. Patel

    IPC分类号： G01N030/00

    CPC分类号： G01N30/6095 ,  G01N30/6082 ,  G01N30/74 ,  G01N30/466 ,  G01N30/32

    摘要： Microfluidic analytical devices and systems have at least one porous element disposed downstream of one or more optical detection regions in a pressure-based separation system. A porous element elevates the backpressure within an optical detection region, thus suppressing bubble formation and enhancing optical detection. Various types of porous elements include porous membranes, packed particulate material, and polymerized monoliths. Preferred devices may be fabricated with substantially planar device layers, including stencil layers, that are directly bonded without adhesives to form a substantially sealed microstructure suitable for performing pressure-based chromatographic separations at elevated operating pressures and with organic solvents.

    摘要翻译： 微流体分析装置和系统在基于压力的分离系统中具有至少一个多孔元件，其设置在一个或多个光学检测区域的下游。 多孔元件提高光学检测区域内的背压，从而抑制气泡形成和增强光学检测。 各种类型的多孔元件包括多孔膜，填充颗粒材料和聚合的整料。 优选的器件可以被制造成具有基本上平面的器件层，包括蜡纸层，其直接粘合而没有粘合剂以形成适合于在升高的操作压力下和与有机溶剂进行基于压力的色谱分离的基本上密封的微结构。