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1.发明授权公开(公告)号：US12053512B2
公开(公告)日：2024-08-06
申请号：US16465675
申请日：2017-12-05
IPC分类号： G01N33/50 , A61K39/00 , G01N33/569
CPC分类号： A61K39/0011 , G01N33/505 , G01N33/5052 , G01N33/56977 , A61K2039/5158 , A61K2039/605 , A61K2039/6081
摘要： The invention provides a method of validating the therapeutic composition that is prepared for immunotherapy of a tumor or cancer. The method includes, triggering of an immune response to a neoepitope of a subject's tumor by: a) obtaining neoepitope sequence data from the tumor of a subject; b) obtaining immune competent cells; c) using the neoepitope sequence data to generate a neoepitope presentation system; d) triggering an immune response by contacting the immune competent cells with the neoepitope presentation system; and e) quantifying the triggering of the immune response from the contacted immune competent cells.
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2.发明公开公开(公告)号：US20240350603A1
公开(公告)日：2024-10-24
申请号：US18761799
申请日：2024-07-02
IPC分类号： A61K39/00 , G01N33/50 , G01N33/569
CPC分类号： A61K39/0011 , G01N33/505 , G01N33/5052 , G01N33/56977 , A61K2039/5158 , A61K2039/605 , A61K2039/6081
摘要： The invention provides a method of validating the therapeutic composition that is prepared for immunotherapy of a tumor or cancer. The method includes, triggering of an immune response to a neoepitope of a subject's tumor by:
a) obtaining neoepitope sequence data from the tumor of a subject;
b) obtaining immune competent cells;
c) using the neoepitope sequence data to generate a neoepitope presentation system;
d) triggering an immune response by contacting the immune competent cells with the neoepitope presentation system; and
e) quantifying the triggering of the immune response from the contacted immune competent cells.-
公开(公告)号：US20230011700A1
公开(公告)日：2023-01-12
申请号：US17933033
申请日：2022-09-16
IPC分类号： G01N33/574 , G01B9/02 , G01B11/06 , G01N33/50
摘要： Systems and methods for predicting an immune response against a tumor in a patient having the tumor are provided. The relative mass or changes of mass of tumor cells or immune cell in the tumor can be ex vivo observed, and an immune status of the tumor can be determined based on the mass of tumor cells or immune cell. The immune status can provide a guidance to predict the immune response against the tumor in the patient.
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公开(公告)号：US11694122B2
公开(公告)日：2023-07-04
申请号：US17890953
申请日：2022-08-18
CPC分类号： G06N20/00 , G06F21/6254 , G06N20/10 , G16H10/60 , G16H40/20 , G16H50/20 , G16H50/50 , G06F21/6245
摘要： A distributed, online machine learning system is presented. Contemplated systems include many private data servers, each having local private data. Researchers can request that relevant private data servers train implementations of machine learning algorithms on their local private data without requiring de-identification of the private data or without exposing the private data to unauthorized computing systems. The private data servers also generate synthetic or proxy data according to the data distributions of the actual data. The servers then use the proxy data to train proxy models. When the proxy models are sufficiently similar to the trained actual models, the proxy data, proxy model parameters, or other learned knowledge can be transmitted to one or more non-private computing devices. The learned knowledge from many private data servers can then be aggregated into one or more trained global models without exposing private data.
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公开(公告)号：US11461690B2
公开(公告)日：2022-10-04
申请号：US15651345
申请日：2017-07-17
摘要： A distributed, online machine learning system is presented. Contemplated systems include many private data servers, each having local private data. Researchers can request that relevant private data servers train implementations of machine learning algorithms on their local private data without requiring de-identification of the private data or without exposing the private data to unauthorized computing systems. The private data servers also generate synthetic or proxy data according to the data distributions of the actual data. The servers then use the proxy data to train proxy models. When the proxy models are sufficiently similar to the trained actual models, the proxy data, proxy model parameters, or other learned knowledge can be transmitted to one or more non-private computing devices. The learned knowledge from many private data servers can then be aggregated into one or more trained global models without exposing private data.
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公开(公告)号：US20200011868A1
公开(公告)日：2020-01-09
申请号：US16470072
申请日：2017-12-17
IPC分类号： G01N33/574 , G01N33/50 , G01B9/02 , G01B11/06
摘要： Systems and methods for predicting an immune response against a tumor in a patient having the tumor are provided. The relative mass or changes of mass of tumor cells or immune cell in the tumor can be ex vivo observed, and an immune status of the tumor can be determined based on the mass of tumor cells or immune cell. The immune status can provide a guidance to predict the immune response against the tumor in the patient.
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公开(公告)号：US11480572B2
公开(公告)日：2022-10-25
申请号：US16470072
申请日：2017-12-17
IPC分类号： G01N33/574 , G01B9/02 , G01B11/06 , G01N33/50
摘要： Systems and methods for predicting an immune response against a tumor in a patient having the tumor are provided. The relative mass or changes of mass of tumor cells or immune cell in the tumor can be ex vivo observed, and an immune status of the tumor can be determined based on the mass of tumor cells or immune cell. The immune status can provide a guidance to predict the immune response against the tumor in the patient.
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公开(公告)号：US20240321416A1
公开(公告)日：2024-09-26
申请号：US18677737
申请日：2024-05-29
发明人： Nicholas J. Witchey
CPC分类号： G16H10/60 , G06F21/00 , G06F21/645 , G06Q10/10 , G06Q30/018 , H04W12/02 , G06Q2250/30
摘要： Healthcare transaction validation systems and methods are presented. Healthcare transactions associated with a stakeholder are compiled into a chain of healthcare transaction blocks. The chain can be considered a chronicle of person's healthcare path through life. When a transaction is conducted, the corresponding healthcare parameters (e.g., inputs, outputs, clinical evidence, outcomes, etc.) are sent to one or more validation devices. The devices establish a validity of the transaction and generate a new block via a proof-of-work principle. Once the new block has been calculated it can be appended to the stakeholder's health care blockchain.
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公开(公告)号：US12040419B2
公开(公告)日：2024-07-16
申请号：US18076302
申请日：2022-12-06
IPC分类号： H01L31/052 , H01L31/042 , H01L31/054 , H02S20/32
CPC分类号： H01L31/052 , H01L31/0547 , H02S20/32 , H01L31/042
摘要： Described are optical devices, such as photovoltaic modules that include features such as solar tracking, solar concentration, tandem cell arrangements, and thermal management to achieve high photovoltaic efficiency. The photovoltaic modules can be constructed using a variety of different materials and configurations or as a monoblock functionally graded structure to limit manufacturing, operational, and maintenance complexities while achieving high performance. The use of thermal management structures directly integrated into a photovoltaic cell can maintain such cells at desirable temperatures, which can be beneficial in optical concentrating configurations.
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公开(公告)号：US11951391B2
公开(公告)日：2024-04-09
申请号：US18471727
申请日：2023-09-21
IPC分类号： A63F13/358 , A63F13/216 , A63F13/65 , H04L7/00 , H04L43/08 , H04L43/16 , H04L67/131 , H04L69/28
CPC分类号： A63F13/358 , A63F13/216 , A63F13/65 , H04L7/0041 , H04L43/08 , H04L43/16 , H04L67/131 , H04L69/28
摘要： One exemplary aspect relates to normalizing latency in a networking environment to reduce the chances of creating an unfair advantage. While an exemplary aspect will be discussed in relation to a gaming environment, it is to be appreciated that the techniques disclosed herein can be applied to other environments where latency normalization or the ability to maintain latency between various endpoints is desired. For example, other environments include eSporting, on-line betting, fantasy esports, streaming services, etc. Some more specific examples include World of Warcraft®, Overwatch®, H1Z1®, PUBG®, Fortnite®, Realm Royale®, Planet Side 2®, real-time strategy games, slot machines, electronic poker tournaments, etc.
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