公开(公告)号：US20100016627A1

公开(公告)日：2010-01-21

申请号：US12565532

申请日：2009-09-23

申请人： Naoaki TAOKA ,  Daisuke MORIYAMA ,  Kohei MORI ,  Takahiro OISHI

发明人： Naoaki TAOKA ,  Daisuke MORIYAMA ,  Kohei MORI ,  Takahiro OISHI

IPC分类号： C07C69/66

CPC分类号： C12P7/62 ,  C07C67/313 ,  C07D317/60 ,  C12P17/04 ,  C12P41/002 ,  C07C69/716

摘要： A 2-formylacetic ester derivative represented by the general formula (5) is provided: where R4 represents an alkyl group having 2 to 6 carbon atoms; R5 represents an alkyl group having 1 to 10 carbon atoms; and X represents H, Li, Na or K.

摘要翻译： 提供由通式（5）表示的2-甲酰基乙酸酯衍生物：其中R 4表示具有2至6个碳原子的烷基; R5表示碳原子数1〜10的烷基。 X表示H，Li，Na或K.

公开(公告)号：US20150166481A1

公开(公告)日：2015-06-18

申请号：US14633622

申请日：2015-02-27

申请人： Kohei MORI ,  Masutoshi NOJIRI ,  Akira NISHIYAMA ,  Naoaki TAOKA

发明人： Kohei MORI ,  Masutoshi NOJIRI ,  Akira NISHIYAMA ,  Naoaki TAOKA

IPC分类号： C07D211/60 ,  C07D211/56

CPC分类号： C07D211/60 ,  C07B57/00 ,  C07D211/56 ,  C12P17/12 ,  C12P41/006

摘要： The present invention relates to a method for producing an optically active 3-aminopiperidine or salt thereof. In the method, a racemic nipecotamide is stereoselectively hydrolyzed to obtain an optically active nipecotamide and an optically active nipecotic acid in the presence of an enzyme source derived from an organism, and then the optically active nipecotamide is derived into an optically active aminopiperidine or salt thereof by aroylation, Hofmann rearrangement, deprotection of the amino group and further deprotection; or the optically active nipecotamide is derived into an optically active aminopiperidine or salt thereof by selective protection with BOC, Hofmann rearrangement and further deprotection. It is possible by the present invention to produce an optically active 3-aminopiperidine or salt thereof useful as a pharmaceutical intermediate from an inexpensive and easily available starting material by easy method applicable to industrial manufacturing.

摘要翻译： 本发明涉及一种光学活性3-氨基哌啶或其盐的制备方法。 在该方法中，外消旋的丙内酰胺立体选择性地水解，得到光生活性的哌甲酰胺和光学活性的啮齿二甲酸，在衍生自生物体的酶源存在下，然后将光学活性的哌甲酰胺衍生成光学活性的氨基哌啶或其盐 通过酰化，Hofmann重排，氨基脱保护和进一步去保护; 或通过用BOC，霍夫曼重排和进一步去保护的选择性保护将光学活性的哌甲酰胺衍生成光学活性氨基哌啶或其盐。 通过本发明可以通过适用于工业制造的容易的方法从廉价且容易获得的原料中制备用作药物中间体的光学活性3-氨基哌啶或其盐。

公开(公告)号：US20120074777A1

公开(公告)日：2012-03-29

申请号：US13168469

申请日：2011-06-24

申请人： Akinobu SUGIYAMA ,  Hiroshi FUJIOKA ,  Takanori MATSUNAGA ,  Kohei MORI ,  Toshihide SATAKE

发明人： Akinobu SUGIYAMA ,  Hiroshi FUJIOKA ,  Takanori MATSUNAGA ,  Kohei MORI ,  Toshihide SATAKE

IPC分类号： H02J3/34

CPC分类号： B60L11/1816 ,  B60L8/003 ,  B60L8/006 ,  B60L11/1803 ,  B60L11/1814 ,  B60L2210/12 ,  B60L2220/54 ,  Y02T10/641 ,  Y02T10/7005 ,  Y02T10/7072 ,  Y02T10/7083 ,  Y02T10/7233 ,  Y02T90/127 ,  Y02T90/14 ,  Y10T307/336

摘要： An electric power converting apparatus mainly includes a first power supply circuit, a second power supply circuit, a selection circuit, a control circuit, a bi-directional inverter circuit, and a charge/discharge circuit. The control circuit composed of a microcomputer or a microprocessor such as a DSP controls an operation of the electric power converting apparatus. The first power supply circuit or the second power supply circuit supplies a operation voltage for the control circuit. The first power supply circuit generates the operation voltage for the control circuit based on an AC voltage supplied from the electric power supply system. The second power supply circuit generates the operation voltage for the control circuit based on a DC voltage supplied from a DC power supply in an electric vehicle EV.

摘要翻译： 电力转换装置主要包括第一电源电路，第二电源电路，选择电路，控制电路，双向逆变器电路和充电/放电电路。 由微计算机或DSP等微处理器构成的控制电路控制电力转换装置的动作。 第一电源电路或第二电源电路为控制电路提供工作电压。 第一电源电路基于从电力供应系统提供的AC电压产生用于控制电路的操作电压。 第二电源电路基于从电动车辆EV中的直流电源供给的直流电压来生成控制电路的动作电压。