公开(公告)号：US08338142B2

公开(公告)日：2012-12-25

申请号：US12449645

申请日：2008-02-18

申请人： Kohei Mori ,  Masutoshi Nojiri ,  Akira Nishiyama ,  Naoaki Taoka

发明人： Kohei Mori ,  Masutoshi Nojiri ,  Akira Nishiyama ,  Naoaki Taoka

IPC分类号： C12P17/12

CPC分类号： C07D211/60 ,  C07B57/00 ,  C07D211/56 ,  C12P17/12 ,  C12P41/006

摘要： The present invention relates to a method for producing an optically active 3-aminopiperidine or salt thereof. In the method, a racemic nipecotamide is stereoselectively hydrolyzed to obtain an optically active nipecotamide and an optically active nipecotic acid in the presence of an enzyme source derived from an organism, and then the optically active nipecotamide is derived into an optically active aminopiperidine or salt thereof by aroylation, Hofmann rearrangement, deprotection of the amino group and further deprotection; or the optically active nipecotamide is derived into an optically active aminopiperidine or salt thereof by selective protection with BOC, Hofmann rearrangement and further deprotection. It is possible by the present invention to produce an optically active 3-aminopiperidine or salt thereof useful as a pharmaceutical intermediate from an inexpensive and easily available starting material by easy method applicable to industrial manufacturing.

摘要翻译： 本发明涉及一种光学活性3-氨基哌啶或其盐的制备方法。 在该方法中，外消旋的丙内酰胺立体选择性地水解，得到光生活性的哌甲酰胺和光学活性的啮齿二甲酸，在衍生自生物体的酶源存在下，然后将光学活性的哌甲酰胺衍生成光学活性的氨基哌啶或其盐 通过酰化，Hofmann重排，氨基脱保护和进一步去保护; 或通过用BOC，霍夫曼重排和进一步去保护的选择性保护将光学活性的哌甲酰胺衍生成光学活性氨基哌啶或其盐。 通过本发明可以通过适用于工业制造的容易的方法从廉价且容易获得的原料中制备用作药物中间体的光学活性3-氨基哌啶或其盐。

公开(公告)号：US20100105917A1

公开(公告)日：2010-04-29

申请号：US12449645

申请日：2008-02-18

申请人： Kohei Mori ,  Masutoshi Nojiri ,  Akira Nishiyama ,  Naoaki Taoka

发明人： Kohei Mori ,  Masutoshi Nojiri ,  Akira Nishiyama ,  Naoaki Taoka

IPC分类号： C07D211/98 ,  C12P17/12 ,  C07D211/60

CPC分类号： C07D211/60 ,  C07B57/00 ,  C07D211/56 ,  C12P17/12 ,  C12P41/006

摘要： The present invention relates to a method for producing an optically active 3-aminopiperidine or salt thereof. In the method, a racemic nipecotamide is stereoselectively hydrolyzed to obtain an optically active nipecotamide and an optically active nipecotic acid in the presence of an enzyme source derived from an organism, and then the optically active nipecotamide is derived into an optically active aminopiperidine or salt thereof by aroylation, Hofmann rearrangement, deprotection of the amino group and further deprotection; or the optically active nipecotamide is derived into an optically active aminopiperidine or salt thereof by selective protection with BOC, Hofmann rearrangement and further deprotection. It is possible by the present invention to produce an optically active 3-aminopiperidine or salt thereof useful as a pharmaceutical intermediate from an inexpensive and easily available starting material by easy method applicable to industrial manufacturing.

摘要翻译： 本发明涉及一种光学活性3-氨基哌啶或其盐的制备方法。 在该方法中，外消旋的丙内酰胺立体选择性地水解，得到光生活性的哌甲酰胺和光学活性的啮齿二甲酸，在衍生自生物体的酶源存在下，然后将光学活性的哌甲酰胺衍生成光学活性的氨基哌啶或其盐 通过酰化，Hofmann重排，氨基脱保护和进一步去保护; 或通过用BOC，霍夫曼重排和进一步去保护的选择性保护将光学活性的哌甲酰胺衍生成光学活性氨基哌啶或其盐。 通过本发明可以通过适用于工业制造的容易的方法从廉价且容易获得的原料中制备用作药物中间体的光学活性3-氨基哌啶或其盐。

公开(公告)号：US20100016627A1

公开(公告)日：2010-01-21

申请号：US12565532

申请日：2009-09-23

申请人： Naoaki TAOKA ,  Daisuke MORIYAMA ,  Kohei MORI ,  Takahiro OISHI

发明人： Naoaki TAOKA ,  Daisuke MORIYAMA ,  Kohei MORI ,  Takahiro OISHI

IPC分类号： C07C69/66

CPC分类号： C12P7/62 ,  C07C67/313 ,  C07D317/60 ,  C12P17/04 ,  C12P41/002 ,  C07C69/716

摘要： A 2-formylacetic ester derivative represented by the general formula (5) is provided: where R4 represents an alkyl group having 2 to 6 carbon atoms; R5 represents an alkyl group having 1 to 10 carbon atoms; and X represents H, Li, Na or K.

摘要翻译： 提供由通式（5）表示的2-甲酰基乙酸酯衍生物：其中R 4表示具有2至6个碳原子的烷基; R5表示碳原子数1〜10的烷基。 X表示H，Li，Na或K.

公开(公告)号：US20060105435A1

公开(公告)日：2006-05-18

申请号：US10515658

申请日：2003-06-05

申请人： Takahiro Ohishi ,  Hirokazu Nanba ,  Masanobu Sugawara ,  Masashi Izumida ,  Tatsuya Honda ,  Kohei Mori ,  Satohiro Yanagisawa ,  Nobuo Nagashima ,  Kenji Inoue

发明人： Takahiro Ohishi ,  Hirokazu Nanba ,  Masanobu Sugawara ,  Masashi Izumida ,  Tatsuya Honda ,  Kohei Mori ,  Satohiro Yanagisawa ,  Nobuo Nagashima ,  Kenji Inoue

IPC分类号： C12P13/12 ,  C12P17/00

CPC分类号： C12P13/12 ,  C07C319/06 ,  C07D233/76 ,  C12P17/04 ,  C12P17/10 ,  C12P41/009 ,  C07C323/58

摘要： The present invention provides a simple industrial process for producing an L- or D-optically active α-methylcysteine derivative or its salt, which is a useful pharmaceutical intermediate, from readily available, inexpensive raw materials. In a process for producing an L- or D-optically active α-methylcysteine derivative or its salt, a racemic N-carbamoyl-α-methylcysteine derivative or its salt is D-selectively cyclized with hydantoinase to produce a D-5-methyl-5-thiomethylhydantoin derivative or its salt and an N-carbamoyl-α-methyl-L-cysteine derivative or its salt, which are then subjected to deprotection of the amino group and the sulfur atom, and hydrolysis.

摘要翻译： 本发明提供了一种用于从容易得到的廉价原料生产L-或D-光学活性α-甲基半胱氨酸衍生物或其盐的简单工业方法，其是有用的药物中间体。 在制备L-或D-光学活性α-甲基半胱氨酸衍生物或其盐的方法中，外消旋的N-氨基甲酰基-α-甲基半胱氨酸衍生物或其盐与乙内酰脲酶D选择性环化以产生D-5-甲基 - 5-硫代甲基乙内酰脲衍生物或其盐和N-氨基甲酰基-α-甲基-L-半胱氨酸衍生物或其盐，然后对氨基和硫原子进行脱保护和水解。

公开(公告)号：US20060044200A1

公开(公告)日：2006-03-02

申请号：US11201424

申请日：2005-08-11

申请人： Kohei Mori

发明人： Kohei Mori

IPC分类号： H01Q13/10

CPC分类号： H01Q13/10 ,  H01Q19/30

摘要： The present invention has been made to reduce the size and thickness of a multibeam antenna capable of switching the directivity in multi directions. The present invention provides a multibeam antenna including an antenna element array including one or more feed element and N (N: natural number) parasitic elements, wherein the electrical length of one or more parasitic elements are made variable.

摘要翻译： 本发明是为了减小能够切换多方向性的多波束天线的尺寸和厚度。 本发明提供一种多波束天线，其包括天线元件阵列，其包括一个或多个馈电元件和N（N：自然数）寄生元件，其中一个或多个寄生元件的电长度可变。

公开(公告)号：US5187934A

公开(公告)日：1993-02-23

申请号：US758882

申请日：1991-09-11

申请人： Kohei Mori

发明人： Kohei Mori

IPC分类号： B60T11/20 ,  B60T11/236 ,  F16J15/18

CPC分类号： F16J15/183 ,  B60T11/20 ,  B60T11/236

摘要： A tandem type master cylinder is disclosed having a housing with a through-bore defining an intermediate portion and opposed end portions. The diameter of each end portion is larger than the diameter of the intermediate portion, and the junctures between the end portions and the intermediate portion define step parts within the housing. Seal assemblies are positioned within the housing at the step junctures formed by the intermediate portion and the end portions and are retained in position by a plug secured within each end portion. Primary and Secondary pistons are disposed for guided movement along the intermediate portion of the housing, and return springs are provided within the housing for urging each piston to its initial rest position.

摘要翻译： 公开了一种串联式主缸，具有具有限定中间部分和相对端部的通孔的壳体。 每个端部的直径大于中间部分的直径，并且端部和中间部分之间的接合部限定了壳体内的台阶部分。 密封组件在由中间部分和端部形成的台阶接合处定位在壳体内，并且通过固定在每个端部内的插塞保持就位。 主活塞和次级活塞设置成沿着壳体的中间部分引导运动，并且复位弹簧设置在壳体内，用于将每个活塞推到其初始静止位置。

公开(公告)号：US4989498A

公开(公告)日：1991-02-05

申请号：US374971

申请日：1989-07-03

申请人： Kohei Mori ,  Noboru Sekiguchi

发明人： Kohei Mori ,  Noboru Sekiguchi

IPC分类号： F15B15/14 ,  B60T11/20 ,  B60T11/22 ,  B60T11/236 ,  F16J15/32

CPC分类号： F16J15/3236 ,  B60T11/20 ,  B60T11/22 ,  B60T11/236 ,  F16J15/3248

摘要： Improvement in an annular seal for use in a hydraulic actuator is obtained in accordance with the present invention, which annular seal is of the type including fitting holes to be inserted by projections formed in a piston guide and is adapted to be mounted between a piston guide sleeve and the piston guide, by the provision of annular projections extending in an annular shape and in the axial direction of the seal in the inner and outer circumferential portions with respect to the location of the fitting holes or in the circumferential area of the piston guide corresponding to that circumferential portions.

摘要翻译： 根据本发明获得了用于液压致动器的环形密封件的改进，该环形密封件是包括形成在活塞导向件中的突起插入的装配孔，并且适于安装在活塞导向件 套筒和活塞引导件，通过设置环形突起，其相对于装配孔的位置或活塞导向件的周向区域在内周和外周部分沿环形形状和轴向方向延伸 对应于该周向部分。

公开(公告)号：US4619185A

公开(公告)日：1986-10-28

申请号：US684450

申请日：1984-12-21

申请人： Kohei Mori ,  Haruo Suzuki

发明人： Kohei Mori ,  Haruo Suzuki

IPC分类号： B60T13/563 ,  B60T13/57 ,  F15B9/10

CPC分类号： B60T13/57

摘要： A brake booster includes a plunger which defines a valve mechanism. A stop member is provided to prevent the withdrawal of the plunger, and structure is provided to prevent the disengagement of the stop member from a valve body. Specifically, the valve body is formed with a detent, and a retainer which supports the stop member is formed with a detent which is engageable with the detent on the valve body. The retainer is disposed externally of the stop member, and the detents on both the valve body and the retainer are effective, when engaged, to prevent the disengagement of the stop member from the valve body.

摘要翻译： 制动助力器包括限定阀机构的柱塞。 提供止动构件以防止柱塞的抽出，并且提供结构以防止止动构件从阀体脱离。 具体地，阀体形成有止动件，并且支撑止动构件的保持器形成有可与阀体上的止动件接合的制动器。 保持器设置在止动构件的外部，并且当接合时，阀体和保持器上的棘爪是有效的，以防止止动构件从阀体脱离。

公开(公告)号：US20130082663A1

公开(公告)日：2013-04-04

申请号：US13704120

申请日：2011-09-15

申请人： Kohei Mori ,  Toshihide Satake ,  Akinobu Sugiyama ,  Hiroshi Fujioka ,  Takanori Matsunaga

发明人： Kohei Mori ,  Toshihide Satake ,  Akinobu Sugiyama ,  Hiroshi Fujioka ,  Takanori Matsunaga

IPC分类号： H02J7/00

CPC分类号： H02J7/00 ,  B60L11/1842 ,  H01M10/425 ,  H02J7/0068 ,  Y02E60/721 ,  Y02T10/7005 ,  Y02T10/7072 ,  Y02T90/121 ,  Y02T90/128 ,  Y02T90/14 ,  Y02T90/163 ,  Y04S10/126

摘要： In a discharge system that outputs DC power from a vehicle battery to the outside, improved safety is obtained during discharge of the battery. A discharge system includes an electric car having a battery unit mounted thereon, and a discharge device that discharges the battery unit. The electric car includes a connector to which the discharge device is connected, and a power line that connects the connector and the battery unit to each other. In the power line, switches and switching elements are provided. The switches render the power line conducting upon permission from the discharge device and a battery management unit. The switching elements adjust a current flowing in the power line when the battery unit is discharged.

摘要翻译： 在从车辆电池输出直流电力到外部的放电系统中，在电池放电期间获得改善的安全性。 排气系统包括安装有电池单元的电动汽车以及对蓄电池单元进行放电的放电装置。 电动汽车包括连接有放电装置的连接器和将连接器和电池单元彼此连接的电力线。 在电源线中，提供开关和开关元件。 这些开关使得电源线在放电装置和电池管理单元允许的情况下导通。 当电池单元放电时，开关元件调节在电力线中流动的电流。

公开(公告)号：US08260497B2

公开(公告)日：2012-09-04

申请号：US12498823

申请日：2009-07-07

申请人： Toshihide Satake ,  Hiroshi Fujioka ,  Kohei Mori

发明人： Toshihide Satake ,  Hiroshi Fujioka ,  Kohei Mori

IPC分类号： F16H61/00 ,  B62D5/04 ,  G06F19/00

CPC分类号： F16H59/58

摘要： In the conventional vehicle control device, since a detection timing of turn is late, at the time of making the change of gear ratio based the detection timing, a sense of discomfort is brought to a driver. Moreover, steering wheel angle sensor, yaw rate sensor or lateral acceleration sensor is very expensive, resulting in the cost increase of the vehicle control devices. From information regarding a steering force that can be obtained from an electric power steering device, a turn intention of a driver is detected, and based the turning intention, the change of gear ratio is conducted.

摘要翻译： 在传统的车辆控制装置中，由于回转的检测时刻迟到，所以在根据检测时刻进行变速比的变更时，对驾驶员产生不适感。 此外，方向盘角度传感器，偏航率传感器或横向加速度传感器非常昂贵，导致车辆控制装置的成本增加。 从关于从电动助力转向装置获得的转向力的信息，检测到驾驶员的转弯意图，并且基于转弯意图进行变速比的变化。