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    COMPOSITIONS AND METHODS FOR PRESERVING CELLS OF THE EYE
    4.
    发明申请
    COMPOSITIONS AND METHODS FOR PRESERVING CELLS OF THE EYE 审中-公开
    用于保护眼睛细胞的组合物和方法

    公开(公告)号：US20100034808A1

    公开(公告)日：2010-02-11

    申请号：US12515319

    申请日：2007-11-20

    申请人： Toru Nakazawa

    发明人： Toru Nakazawa

    IPC分类号： A61K39/395 ,  A61K31/7088

    CPC分类号： C07K16/2866 ,  A61K38/217 ,  A61K2039/505 ,  C07K16/241 ,  C07K2317/76 ,  C12N15/1138 ,  C12N2310/14

    摘要： The invention provides a method of preserving ocular cells in a patient having or at risk of developing glaucoma. In particular, microglial cell activation can be decreased, oligodendrocyte loss can be reduced, and/or the viability of retinal ganglion cells can be preserved by administering a selective TNFR2 antagonist to an individual having or at risk of developing glaucoma.

    摘要翻译： 本发明提供一种在患有或有发生青光眼风险的患者中保存眼细胞的方法。 特别地，可以降低小神经胶质细胞的活化，通过向具有发生青光眼或有发展青光眼的个体的个体施用选择性TNFR2拮抗剂，可以降低视网膜神经节细胞的存活力和/或视网膜神经节细胞的存活力。

    Methods and Compositions for Preserving the Viability of Photoreceptor Cells
    5.
    发明申请
    Methods and Compositions for Preserving the Viability of Photoreceptor Cells 有权
    保护感光细胞活力的方法和组合物

    公开(公告)号：US20070287756A1

    公开(公告)日：2007-12-13

    申请号：US11587022

    申请日：2005-04-22

    申请人： Toru Nakazawa

    发明人： Toru Nakazawa

    IPC分类号： A61K47/00 ,  A61P27/02

    CPC分类号： A61K9/0048 ,  A61K9/0051 ,  A61K38/06 ,  A61K38/1793 ,  A61K38/1825 ,  A61K38/19 ,  A61K38/2006 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/241

    摘要： Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering a neuroprotective agent, for example, a substance capable of suppressing endogenous MCP-1, a MCP-1 antagonist, a substance capable of suppressing endogenous TNF-alpha, a TNF-alpha antagonist, a substance capable of suppressing endogenous IL-1 beta, an IL-1 beta antagonist, a substance capable of inducing endogenous bFGF, exogenous bFGF, a bFGF mimetic, and combinations thereof, to a mammal having an eye with retinal detachment. The neuroprotective agent maintains the viability of the photoreceptor cells until such time that the retina becomes reattached to the underlying retinal pigment epithelium and choroid. The treatment minimizes the loss of vision, which otherwise may occur as a result of retinal detachment.

    摘要翻译： 提供了用于维持视网膜脱离后感光细胞活力的方法和组合物。 可以通过给予神经保护剂，例如能够抑制内源性MCP-1的物质，MCP-1拮抗剂，能够抑制内源性TNF-α的物质，TNF-α拮抗剂， 能够抑制内源性IL-1β的物质，能够诱导内源性bFGF的物质，外源性bFGF，bFGF模拟物及其组合的物质，其具有视网膜脱离的眼睛的哺乳动物。 神经保护剂维持光感受器细胞的活力，直到视网膜再次附着于下面的视网膜色素上皮和脉络膜。 治疗可以最大限度地减少由于视网膜脱离而导致的视力丧失。

    Image forming apparatus having a projection provided on a bottom face of an upper casing
    6.
    发明授权
    Image forming apparatus having a projection provided on a bottom face of an upper casing 有权
    图像形成装置具有设置在上壳体的底面上的突起

    公开(公告)号：US07272338B2

    公开(公告)日：2007-09-18

    申请号：US11177786

    申请日：2005-07-08

    申请人： Takashi Karasawa ,  Toru Nakazawa ,  Tsuyoshi Miyawaki

    发明人： Takashi Karasawa ,  Toru Nakazawa ,  Tsuyoshi Miyawaki

    IPC分类号： G03G15/00 ,  G03G21/16

    CPC分类号： G03G15/60

    摘要： A prop is extending from the printer unit upwards. A rear end portion of an upper casing is coupled with an upper portion of the prop pivotably in a vertical direction. A transparent platen is provided on a top face of the upper casing. An image capturer is provided in the upper casing and operable to capture an image on an original disposed on the platen and to output image data. A projection is provided on a bottom face of the upper casing and is extending in a front-rear direction of the upper casing. The projection has a rear end face adapted to be supported by the prop when the upper casing is placed in a first position causing the platen to extend horizontally. The rear end face extends obliquely in a forward-downward direction.

    摘要翻译： 支架从打印机单元向上延伸。 上壳体的后端部分在垂直方向可枢转地与支架的上部联接。 透明压板设置在上壳体的顶面上。 图像捕获器设置在上壳体中并且可操作以捕获设置在压板上的原稿上的图像并输出图像数据。 在上壳体的底面设置突起，并且在上壳体的前后方向上延伸。 突起具有后端面，其适于在上壳体处于第一位置时被支撑件支撑，从而使压板水平延伸。 后端面向前下方向倾斜地延伸。

    Electrophotographic process including controlling applied current values
    8.
    发明授权
    Electrophotographic process including controlling applied current values 失效
    电子照相过程包括控制施加的电流值

    公开(公告)号：US4629674A

    公开(公告)日：1986-12-16

    申请号：US625536

    申请日：1984-06-28

    申请人： Toru Nakazawa

    发明人： Toru Nakazawa

    IPC分类号： G03G15/02 ,  G03G13/02 ,  G03G13/22 ,  G03G13/16

    CPC分类号： G03G13/22 ,  Y10S430/102

    摘要： An electrophotographic process includes performing removal of electricity or pre-charging by direct current corona discharge and main charging by direct current corona discharge of a polarity reverse to the polarity for removal of electric charge or pre-charging on an organic photoconductive photosensitive layer chargeable at both the positive and negative polarities. Then is performed imagewise exposure, development with a toner and transfer of the toner image. Such operations are repeated to form plural images. Main charging is carried out with an applied current such that the photosensitive layer surface potential is saturated at 500 to 700 volts (absolute value) and removal of electric charge or pre-charging is carried out with at an applied current lower than the saturation injected current value and corresponding to 40 to 90% thereof.

    摘要翻译： 电子照相方法包括通过直流电晕放电进行电除电或预充电，并通过直流电晕放电，其极性与极性相反，以消除电荷或预充电在有两层可带电的感光层上 正负极性。 然后进行图像曝光，用调色剂显影和转印调色剂图像。 重复这样的操作以形成多个图像。 以施加的电流进行主充电，使得感光层表面电位在500至700伏特（绝对值）下饱和，并且以低于饱和注入电流的施加电流进行电荷或预充电的去除 值，相当于其40〜90％。