公开(公告)号：US20100142850A1

公开(公告)日：2010-06-10

申请号：US12704350

申请日：2010-02-11

申请人： Nathan K. Weiner ,  Patrick J. Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David A. Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas P. Regan ,  David Bradbury ,  Eric Earl McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel Katz ,  Ksenia Oleink-Ovod

发明人： Nathan K. Weiner ,  Patrick J. Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David A. Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas P. Regan ,  David Bradbury ,  Eric Earl McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel Katz ,  Ksenia Oleink-Ovod

IPC分类号： G06K9/40

CPC分类号： G01N21/6428 ,  G01N21/253 ,  G01N21/6452 ,  G01N2021/6471

摘要： An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.

摘要翻译： 描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和 探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步 基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联 一个或多个位置校正值。

公开(公告)号：US07983467B2

公开(公告)日：2011-07-19

申请号：US12704350

申请日：2010-02-11

申请人： Nathan K. Weiner ,  Patrick J. Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David A. Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas P. Regan ,  David Bradbury ,  Eric Earl McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel M. Katz ,  Ksenia Oleink-Ovod

发明人： Nathan K. Weiner ,  Patrick J. Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David A. Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas P. Regan ,  David Bradbury ,  Eric Earl McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel M. Katz ,  Ksenia Oleink-Ovod

IPC分类号： G06K9/00

CPC分类号： G01N21/6428 ,  G01N21/253 ,  G01N21/6452 ,  G01N2021/6471

摘要： An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.

公开(公告)号：US07871812B2

公开(公告)日：2011-01-18

申请号：US10975788

申请日：2004-10-27

申请人： Nathan K. Weiner ,  Patrick J. Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David A. Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas P. Regan ,  David Bradbury ,  Eric Earl McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel M. Katz ,  Ksenia Oleink-Ovod

发明人： Nathan K. Weiner ,  Patrick J. Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David A. Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas P. Regan ,  David Bradbury ,  Eric Earl McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel M. Katz ,  Ksenia Oleink-Ovod

IPC分类号： C12M1/34 ,  C12M3/00

CPC分类号： G01N21/6428 ,  G01N21/253 ,  G01N21/6452 ,  G01N2021/6471

摘要： An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.

摘要翻译： 描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和 探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步 基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联 一个或多个位置校正值。

公开(公告)号：US07689022B2

公开(公告)日：2010-03-30

申请号：US10389194

申请日：2003-03-14

申请人： Nathan K. Weiner ,  Patrick J. Odoy ,  Erik Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David A. Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas P. Regan ,  David Bradbury ,  Eric Earl McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel Katz ,  Ksenia Oleink-Ovod

发明人： Nathan K. Weiner ,  Patrick J. Odoy ,  Erik Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David A. Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas P. Regan ,  David Bradbury ,  Eric Earl McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel Katz ,  Ksenia Oleink-Ovod

IPC分类号： G06K9/00

CPC分类号： G01N21/6428 ,  G01N21/253 ,  G01N21/6452 ,  G01N2021/6471

摘要： An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.

公开(公告)号：US20110243411A1

公开(公告)日：2011-10-06

申请号：US13156928

申请日：2011-06-09

申请人： Nathan K. Weiner ,  Patrick J. Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman DeWeerd ,  David A. Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas P. Regan ,  David Bradbury ,  Eric Earl McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel M. Katz ,  Ksenia Oleink-Ovod

发明人： Nathan K. Weiner ,  Patrick J. Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman DeWeerd ,  David A. Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas P. Regan ,  David Bradbury ,  Eric Earl McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel M. Katz ,  Ksenia Oleink-Ovod

IPC分类号： G06K9/00

CPC分类号： G01N21/6428 ,  G01N21/253 ,  G01N21/6452 ,  G01N2021/6471

摘要： An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.

公开(公告)号：US20120235016A1

公开(公告)日：2012-09-20

申请号：US13480888

申请日：2012-05-25

申请人： Nathan K. Weiner ,  Patrick J. Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David A. Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas P. Regan ,  David Bradbury ,  Eric Earl McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel Katz ,  Ksenia Oleinik-Ovod

发明人： Nathan K. Weiner ,  Patrick J. Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David A. Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas P. Regan ,  David Bradbury ,  Eric Earl McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel Katz ,  Ksenia Oleinik-Ovod

IPC分类号： H01L27/146

CPC分类号： G01N21/6428 ,  G01N21/253 ,  G01N21/6452 ,  G01N2021/6471

摘要： An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.

摘要翻译： 描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和 探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步 基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联 一个或多个位置校正值。

公开(公告)号：US20050057676A1

公开(公告)日：2005-03-17

申请号：US10975788

申请日：2004-10-27

申请人： Nathan Weiner ,  Patrick Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas Regan ,  David Bradbury ,  Eric McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel Katz ,  Ksenia Oleink-Ovod

发明人： Nathan Weiner ,  Patrick Odoy ,  Eric Schultz ,  Mark Jones ,  James Overbeck ,  Herman Deweerd ,  David Stura ,  Albert Bukys ,  Tim Woolaver ,  Thomas Regan ,  David Bradbury ,  Eric McKenzie ,  Roger DiPaolo ,  Christopher Miles ,  Joel Katz ,  Ksenia Oleink-Ovod

IPC分类号： G01N21/64 ,  G01N21/25 ,  G01N33/483 ,  G01N33/53 ,  G01N37/00 ,  G01J3/30

CPC分类号： G01N21/6428 ,  G01N21/253 ,  G01N21/6452 ,  G01N2021/6471

摘要： An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.

摘要翻译： 描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和 探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步 基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联 一个或多个位置校正值。

公开(公告)号：US20050030601A1

公开(公告)日：2005-02-10

申请号：US10868590

申请日：2004-06-14

申请人： David Smith ,  Gregory Loney ,  Nathan Weiner ,  Christopher Miles ,  Albert Bukys ,  Akim Lennhoff ,  Robert Kuimelis

发明人： David Smith ,  Gregory Loney ,  Nathan Weiner ,  Christopher Miles ,  Albert Bukys ,  Akim Lennhoff ,  Robert Kuimelis

IPC分类号： G01N21/27 ,  G01N21/64 ,  G06F15/00

CPC分类号： G01N21/6452 ,  G01N21/278

摘要： In one embodiment a method for reducing variation in a plurality of scanners is described. The method comprises directing an excitation beam at a calibration standard in each of the plurality of scanners, where one of the plurality of scanners is a designated scanner; detecting emission data for each of the plurality of scanners from a plurality of fluorescent molecules disposed on the calibration standard, where the emission data is responsive to the excitation beam; determining variation in the emission data of one or more of the plurality of scanners based, at least in part, upon the emission data of the designated scanner; and adjusting one or more parameters in one or more of the plurality of scanners based, at least in part, upon the determined variation.

摘要翻译： 在一个实施例中，描述了用于减少多个扫描器中的变化的方法。 该方法包括以多个扫描仪中的每一个的校准标准来引导激励光束，其中多个扫描仪中的一个是指定的扫描器; 从布置在校准标准上的多个荧光分子检测多个扫描器中的每一个的发射数据，其中发射数据响应于激发光束; 至少部分地基于所指定的扫描仪的发射数据来确定所述多个扫描仪中的一个或多个的发射数据的变化; 以及至少部分地基于所确定的变化来调整所述多个扫描器中的一个或多个中的一个或多个参数。

公开(公告)号：US08679262B2

公开(公告)日：2014-03-25

申请号：US13589671

申请日：2012-08-20

申请人： Peter Honkanen ,  Albert Bukys ,  Dave Bradbury

发明人： Peter Honkanen ,  Albert Bukys ,  Dave Bradbury

IPC分类号： B08B3/04 ,  B08B5/04

CPC分类号： B08B3/04 ,  B01L3/0244 ,  B01L99/00 ,  B41J29/17 ,  G01N35/1004 ,  G01N2035/1037

摘要： A multi-chambered deposition pin wash station is provided. The wash station includes a lower chamber and an upper drain basin connected by a plurality of wash tubes. Cleaning fluid is provided to the lower chamber and passes through the cleaning tubes into the upper drain basin. The cleaning tubes are adapted to clean a single deposition pin with a single tube per wash cycle.

摘要翻译： 提供了多腔沉积针清洗台。 洗涤站包括通过多个洗涤管连接的下室和上排水槽。 清洗液被提供到下室，并通过清洗管进入上排水槽。 清洗管适用于每个洗涤周期用单个管清洁单个沉积销。

公开(公告)号：US08246760B2

公开(公告)日：2012-08-21

申请号：US13232593

申请日：2011-09-14

申请人： Peter Honkanen ,  Albert Bukys ,  Dave Bradbury

发明人： Peter Honkanen ,  Albert Bukys ,  Dave Bradbury

IPC分类号： B08B3/00

CPC分类号： B08B3/04 ,  B01L3/0244 ,  B01L99/00 ,  B41J29/17 ,  G01N35/1004 ,  G01N2035/1037

摘要： A multi-chambered deposition pin wash station is provided. The wash station includes a lower chamber and an upper drain basin connected by a plurality of wash tubes. Cleaning fluid is provided to the lower chamber and passes through the cleaning tubes into the upper drain basin. The cleaning tubes are adapted to clean a single deposition pin with a single tube per wash cycle.

摘要翻译： 提供了多腔沉积针清洗台。 洗涤站包括通过多个洗涤管连接的下室和上排水槽。 清洗液被提供到下室，并通过清洗管进入上排水槽。 清洗管适用于每个洗涤周期用单个管清洁单个沉积销。