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    Focusing of microscopes and reading of microarrays
    5.
    发明申请
    Focusing of microscopes and reading of microarrays 有权
    聚焦显微镜和阅读微阵列

    公开(公告)号：US20050285049A1

    公开(公告)日：2005-12-29

    申请号：US11145529

    申请日：2005-06-03

    Applicant: Jean Montagu ,  James Overbeck

    Inventor： Jean Montagu ,  James Overbeck

    IPC: G01N21/64 ,  G02B21/16

    CPC classification number: G01N21/6458 ,  G01N21/6428 ,  G01N21/6452 ,  G02B21/16

    Abstract: Microscopes, including viewing and other microscopic systems, employ a hinged, tiltable plate to adjust focus on a flat object such as a microscope slide or biochip by motion, achieved by tilting, which is substantially normal to the focus point on the plane of the object. By employing two such tiltable arrangements, relatively long scan lines of e.g., flying objective, single pixel on-axis scanning can be accommodated. The tilting support plate is specifically constructed to provide tailored locations for different objects in series along the Y axis of the plate. The plate can accommodate heaters and cooled plates and/or the flat object being examined. In a fluorescence scanning microscope, locations are specifically adapted to receive microscope slides and biochip cartridges such as Affymetrix's “Gene Chip®”. A scanning microscope under computer control, employing such a focusing action, enables unattended scanning of biochips with a simple and economical instrument. Also shown are flexure-mounting of a support plate to define the hinge axis, techniques for automatically determining position and focus, and a rotatably oscillating flying micro-objective scanner combined with the tilting plane focus system. Construction and control techniques are shown that realize simple and accurate focusing. Methods of examination of biological materials are disclosed. Simple and efficient focused scanning with a flying micro-objective of ordered arrays of nucleotides and nucleic acid fragments carried upon a microscope slide or other substrate is disclosed. Quantified fluorescence imaging is economically achieved by combined use of the described scanning and focusing arrangement and use of simple and accurate calibration modules respectively for example for Affymetrix's “Gene Chip” microarray modules and for microscope slides.

    Abstract translation: 显微镜，包括观察和其他微观系统，采用铰接的可倾斜板，以通过倾斜来调节焦点在诸如显微镜载玻片或生物芯片的平面物体上，该倾斜基本上垂直于物体平面上的焦点 。 通过采用两个这样的可倾斜布置，例如飞行物镜的相对长的扫描线可以容纳单个像素的轴上扫描。 倾斜支撑板被特别地构造成为沿着板的Y轴串联的不同物体提供定制的位置。 该板可容纳加热器和冷却板和/或被检查的平面物体。 在荧光扫描显微镜中，位置特别适用于接收显微镜载片和生物芯片盒，如Affymetrix的“Gene Chip”。 采用这种聚焦作用的计算机控制下的扫描显微镜可以通过简单经济的仪器进行无人值守的生物芯片扫描。 还示出了支撑板的弯曲安装以限定铰链轴线，用于自动确定位置和焦点的技术以及与倾斜平面聚焦系统组合的可旋转摆动的飞行微型物体扫描仪。 显示了实现简单准确聚焦的结构和控制技术。 公开了生物材料的检测方法。 公开了用显微镜载玻片或其它基底上携带的核苷酸和核酸片段的有序阵列的飞行微观目标的简单有效的聚焦扫描。 通过组合使用所述的扫描和聚焦装置以及分别使用简单且精确的校准模块，例如Affymetrix的“Gene Chip”微阵列模块和显微镜幻灯片，经济地实现了定量荧光成像。

    Laser system for vision correction
    6.
    发明申请
    Laser system for vision correction 有权
    用于视力矫正的激光系统

    公开(公告)号：US20050278004A1

    公开(公告)日：2005-12-15

    申请号：US11102985

    申请日：2005-04-11

    Applicant: Roger Steinert ,  James Overbeck

    Inventor： Roger Steinert ,  James Overbeck

    IPC: A61B3/113 ,  A61F9/008 ,  A61F9/01 ,  A61N1/00

    CPC classification number: A61B3/113 ,  A61F9/00802 ,  A61F2009/00846 ,  A61F2009/00872

    Abstract: A laser system for treating an eye having a cornea, the laser system including a laser beam source capable of generating a laser beam, an eye position detector which includes at least a corneal tracker, the corneal tracker being responsive to movement of an anterior portion of the cornea, the corneal tracker constructed to detect movement of the cornea based on a set of spaced apart optical manifestations from the outer surface of the anterior portion of the cornea, and a beam controller, the beam controller being responsive to the eye position detector to direct the laser beam with controlled energy from the laser beam source to a desired location on the eye.

    Abstract translation: 一种用于治疗具有角膜的眼睛的激光系统，所述激光系统包括能够产生激光束的激光束源，至少包括角膜跟踪器的眼睛位置检测器，所述角膜跟踪器响应于所述角膜跟踪器的前部的运动， 所述角膜，所述角膜跟踪器被构造成基于从所述角膜的前部的外表面的一组间隔开的光学表现来检测所述角膜的运动，以及光束控制器，所述光束控制器响应于所述眼睛位置检测器 将具有受控能量的激光束从激光束源引导到眼睛上的期望位置。

    Optical measurement device and related process
    7.
    发明申请
    Optical measurement device and related process 有权
    光学测量装置及相关工艺

    公开(公告)号：US20050122518A1

    公开(公告)日：2005-06-09

    申请号：US10991453

    申请日：2004-11-18

    Applicant: James Overbeck ,  Michael Galen ,  Richard Van Andel ,  Christian Boes

    Inventor： James Overbeck ,  Michael Galen ,  Richard Van Andel ,  Christian Boes

    IPC: G01J3/51 ,  A61B1/00 ,  A61B1/04 ,  A61B1/24 ,  A61B5/00 ,  G01N21/27 ,  G01N21/57 ,  G01N21/25

    CPC classification number: A61B1/24 ,  A61B1/00052 ,  A61B1/00186 ,  A61B1/0669 ,  A61B5/0088 ,  G01J3/0208 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0278 ,  G01J3/465 ,  G01J3/508 ,  G01J3/51

    Abstract: An instrument and related process for measuring color, shade, gloss, shape and/or translucence of a tooth. First, the instrument uses searchlight illumination to illuminate a tooth with constant irradiance. Second, the instrument uses colorimetric imaging to collect time-separated frames of different wavelengths of light reflected from a tooth and to combine those frames into a color image. Third, the instrument includes a sanitary shield to establish a reference color and a predetermined distance to a target tooth. Fourth, the instrument provides line-of-sight viewing so an operator may simultaneously view a display of the image on the instrument and the object being measured. Fifth, the instrument is impervious to pollutants because it incorporates a sealed measurement window. Sixth, optical measurements of a tooth taken by a dentist are compared to optical measurements of a prosthetic restoration for that tooth to confirm satisfactory matching of optical characteristics of the tooth and restoration.

    Abstract translation: 用于测量牙齿的颜色，阴影，光泽，形状和/或半透明度的仪器和相关过程。 首先，仪器使用探照灯照明照射具有恒定辐照度的牙齿。 其次，仪器使用比色成像来收集从牙齿反射的不同波长的光的时间分隔的帧，并将这些帧组合成彩色图像。 第三，仪器包括卫生护罩以建立参考颜色并且与目标牙齿具有预定距离。 第四，仪器提供视线观看，因此操作者可以同时观察仪器上的图像显示和正被测量的物体。 第五，仪器不含污染物，因为它包含一个密封的测量窗口。 第六，将由牙医取得的牙齿的光学测量值与该牙齿的假体修复体的光学测量值进行比较，以确认牙齿和修复体的光学特性的令人满意的匹配。

    Adjustable base structure
    8.
    发明授权
    Adjustable base structure 失效

    公开(公告)号：US06572061B2

    公开(公告)日：2003-06-03

    申请号：US09888018

    申请日：2001-06-25

    Applicant: James Overbeck

    Inventor： James Overbeck

    IPC: F16M1136

    CPC classification number: A47C7/008 ,  A47C4/20 ,  A47C9/105 ,  F16M11/245 ,  F16M13/00

    Abstract: An adjustable base structure supports a person in an upright attitude on uneven terrain and comprises a plate and multiple legs independently pivotally connected to the plate. When in an operative mode, the legs diverge from each other and from the plate and rest on the terrain to orient the plate horizontally. A cable connects the legs and maintains them in the operative mode. A bushing on the plate receives a post of a carrier that is attached to a seat. When the carrier post is in the bushing, the person can sit upright regardless of the contour of the terrain. A dome-shaped pad is joined to each leg for swiveling in a manner that accommodates the terrain and that supports the adjustable base structure in soft soil. Different lengths of the cable are storable inside one of the legs to adjustably limit the amount of pivoting of the legs.

    Systems and methods for monitoring a process output with a highly abridged spectrophotometer
    10.
    发明申请
    Systems and methods for monitoring a process output with a highly abridged spectrophotometer 有权
    用高度缓冲分光光度计监测过程输出的系统和方法

    公开(公告)号：US20060244960A1

    公开(公告)日：2006-11-02

    申请号：US11397547

    申请日：2006-04-04

    Applicant: James Overbeck ,  Thomas Richardson

    Inventor： James Overbeck ,  Thomas Richardson

    IPC: G01J3/00

    CPC classification number: G01J3/50 ,  G01J3/027 ,  G01J3/28 ,  G01J3/462 ,  G01N21/31

    Abstract: A method for monitoring a process output with a highly abridged spectrophotometer. The method includes securing spectral data for each spectral primary used in a process, measuring spectral data with a highly abridged spectrophotometer for a sample produced by the process, determining an estimated weight for each spectral primary in the sample, and computing spectral data representative of the sample based on the secured spectral data and the determined estimated weight for each spectral primary in the sample.

    Abstract translation: 用高度缓冲分光光度计监测过程输出的方法。 该方法包括确保在过程中使用的每个光谱原色的光谱数据，用用于由该过程产生的样品的高度缓冲的分光光度计测量光谱数据，确定样品中每个光谱原始的估计权重，以及计算代表 基于安全光谱数据的样本和样本中每个光谱初级的确定的估计权重。

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