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1.发明申请公开(公告)号：US20200047175A1
公开(公告)日：2020-02-13
申请号：US16516500
申请日：2019-07-19
Applicant: Natrix Separations Inc.
Inventor： Amro Ragheb , Gary Skarja
Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
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2.发明申请公开(公告)号：US20180297023A1
公开(公告)日：2018-10-18
申请号：US15947078
申请日：2018-04-06
Applicant: Natrix Separations Inc.
Inventor： Amro Ragheb , Gary Skarja
CPC classification number: B01J39/19 , B01D15/34 , B01J20/267 , B01J20/28033 , B01J20/291 , B01J39/26 , C07K1/18 , C07K1/22
Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
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Patent Agency Ranking
3.发明申请Chromatography Membranes Formed by Thiol-Ene or Thiol-Yne Click Polymerization Reactions 有权由Thiol-Ene或Thiol-Yne点击聚合反应形成的色谱膜公开(公告)号：US20160243538A1
公开(公告)日：2016-08-25
申请号：US15049625
申请日：2016-02-22
Applicant: Natrix Separations Inc.
Inventor： Amro Ragheb , Gary Skarja
CPC classification number: B01J39/19 , B01D15/34 , B01J20/267 , B01J20/28033 , B01J20/291 , B01J39/26 , C07K1/18 , C07K1/22
Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
Abstract translation: 公开了复合材料及其制备方法。 复合材料包括支撑构件和交联凝胶，其中交联凝胶是由硫醇烯或硫醇 - 聚合和交联合成的聚合物。 交联凝胶可以通过硫醇 - 烯或硫醇 - 接枝反应进行官能化，或者与聚合反应同时进行，或者在两步法中作为第二步。 复合材料可用作色谱分离介质。
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公开(公告)号：US09962691B2
公开(公告)日：2018-05-08
申请号：US15049625
申请日：2016-02-22
Applicant: Natrix Separations Inc.
Inventor： Amro Ragheb , Gary Skarja
CPC classification number: B01J39/19 , B01D15/34 , B01J20/267 , B01J20/28033 , B01J20/291 , B01J39/26 , C07K1/18 , C07K1/22
Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
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5.发明申请Chromatographic Media for Storage and Delivery of Therapeutic Biologics and Small Molecules 审中-公开用于储存和递送治疗性生物制剂和小分子的色谱介质公开(公告)号：US20130189322A1
公开(公告)日：2013-07-25
申请号：US13744583
申请日：2013-01-18
Applicant: Natrix Separations Inc.
Inventor： Charles H. Honeyman , John A. Chickosky , Molly S. McGlaughlin , Amro Ragheb
IPC: A61K47/48
CPC classification number: A61K9/7007 , G01N33/544
Abstract: Described are composite materials and methods of making and using them for the storage and delivery of unstable drugs or biologics. In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; a macroporous cross-linked gel, comprising a plurality of macropores; a therapeutic agent; and a stabilizing agent.
Abstract translation: 描述了制备和使用它们用于储存和递送不稳定药物或生物制剂的复合材料和方法。 在某些实施例中，复合材料包括支撑构件，其包括延伸穿过支撑构件的多个孔; 大孔交联凝胶，其包含多个大孔; 治疗剂; 和稳定剂。
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公开(公告)号：US10357766B2
公开(公告)日：2019-07-23
申请号：US15947078
申请日：2018-04-06
Applicant: Natrix Separations Inc.
Inventor： Amro Ragheb , Gary Skarja
Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
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公开(公告)号：US20140273158A1
公开(公告)日：2014-09-18
申请号：US14200615
申请日：2014-03-07
Applicant: Natrix Separations Inc.
Inventor： Amro Ragheb
IPC: B01J20/291 , B01D15/42
CPC classification number: B01J20/291 , B01D15/42 , B01J20/28033 , B01J20/28085 , B01J20/28097
Abstract: Disclosed are composite materials and methods of using them for chromatography. The composite materials retain their performance characteristics, such as binding capacity, flux, or percent recovery, under caustic conditions (e.g., 1 M NaOH for 24 h). In certain embodiments, the composite materials or membranes comprise a support member, comprising a plurality of pores extending through the support member; and a cross-linked gel. Importantly, the cross-linker and the monomer do not contain backbone ester linkages. The composite materials may be used in the separation or purification of a biological molecule or biological ion.
Abstract translation: 公开了将其用于色谱法的复合材料和方法。 在苛性碱条件下（例如1M NaOH 24小时），复合材料保持其性能特征，例如结合能力，通量或回收百分比。 在某些实施例中，复合材料或膜包括支撑构件，其包括延伸穿过支撑构件的多个孔; 和交联凝胶。 重要的是，交联剂和单体不含骨架酯键。 复合材料可用于分离或纯化生物分子或生物离子。
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