公开(公告)号：US20180353939A1

公开(公告)日：2018-12-13

申请号：US16055786

申请日：2018-08-06

Applicant: Natrix Separations Inc.

Inventor： Elena N. Komkova ,  Charles H. Honeyman

IPC: B01J20/32 ,  B01J20/291 ,  B01J43/00 ,  B01D15/36 ,  C07K1/16 ,  B01J20/286 ,  B01D15/32 ,  B01J47/12 ,  B01J41/20 ,  B01J39/26 ,  B01D15/38 ,  B01J20/28

CPC classification number: B01J20/3285 ,  B01D15/327 ,  B01D15/36 ,  B01D15/362 ,  B01D15/363 ,  B01D15/3847 ,  B01J20/28033 ,  B01J20/286 ,  B01J20/291 ,  B01J39/26 ,  B01J41/20 ,  B01J43/00 ,  B01J47/12 ,  C07K1/165

Abstract: Described are composite materials and methods of using them for mixed-mode chromatography. In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; and a multi-functional cross-linked gel. The multi-functional cross-linked gel possesses at least two of the following functions or characteristics: cationic, anionic, hydrophobic, hydrophilic, thiophilic, hydrogen bond donating, hydrogen bond accepting, pi-pi bond donating, pi-pi bond accepting, or metal chelating. The composite materials may be used in the separation or purification of a biological molecule or biological ion.

公开(公告)号：US20140238935A1

公开(公告)日：2014-08-28

申请号：US14190650

申请日：2014-02-26

Applicant: Natrix Separations Inc.

Inventor： Elena N. Komkova ,  Charles H. Honeyman

IPC: B01J20/32 ,  B01J43/00 ,  B01J20/291 ,  B01D15/36

CPC classification number: B01J20/3285 ,  B01D15/327 ,  B01D15/36 ,  B01D15/362 ,  B01D15/363 ,  B01D15/3847 ,  B01J20/28033 ,  B01J20/286 ,  B01J20/291 ,  B01J39/26 ,  B01J41/20 ,  B01J43/00 ,  B01J47/12 ,  C07K1/165

Abstract: Described are composite materials and methods of using them for mixed-mode chromatography. In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; and a multi-functional cross-linked gel. The multi-functional cross-linked gel possesses at least two of the following functions or characteristics: cationic, anionic, hydrophobic, hydrophilic, thiophilic, hydrogen bond donating, hydrogen bond accepting, pi-pi bond donating, pi-pi bond accepting, or metal chelating. The composite materials may be used in the separation or purification of a biological molecule or biological ion.

Abstract translation: 描述了将其用于混合模式层析的复合材料和方法。 在某些实施例中，复合材料包括支撑构件，其包括延伸穿过支撑构件的多个孔; 和多功能交联凝胶。 多功能交联凝胶具有以下功能或特性中的至少两个：阳离子，阴离子，疏水，亲水，亲硫化，给氢氢键，接受氢键，π-π键，π-π键接受或 金属螯合。 复合材料可用于分离或纯化生物分子或生物离子。