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24 条记录 (耗时 0.042 秒)

    Compositions and methods for the treatment of cancer
    1.
    发明授权
    Compositions and methods for the treatment of cancer 有权
    用于治疗癌症的组合物和方法

    公开(公告)号：US08513292B2

    公开(公告)日：2013-08-20

    申请号：US12664345

    申请日：2008-06-19

    申请人： Neil Westlund ,  Jason Hill ,  Mark A. Ashwell ,  Nivedita Namdev ,  Jianqiang Wang ,  Syed Ali

    发明人： Neil Westlund ,  Jason Hill ,  Mark A. Ashwell ,  Nivedita Namdev ,  Jianqiang Wang ,  Syed Ali

    IPC分类号： A61K31/437 ,  C07D221/06 ,  C07D471/06

    CPC分类号： C07D487/06 ,  C07D471/06

    摘要： The present invention relates to pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound or pyrrolidine-2,5-dione compound of the present invention. (Ia) (Ib) (IIa) (IIIb) Where U is independently selected from: (I) or (II) where U is independently selected from:

    摘要翻译： 本发明涉及吡咯烷-2,5-二酮化合物及其制备方法。 本发明还涉及包含吡咯烷-2,5-二酮化合物的药物组合物。 本发明提供了通过向有需要的受试者施用治疗有效量的本发明化合物或吡咯烷-2,5-二酮化合物来治疗细胞增殖性疾病如癌症的方法。 （Ia）（Ib）（IIa）（IIIb）其中U独立地选自：（I）或（II）其中U独立地选自：

    Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
    7.
    发明授权
    Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer 有权
    吡咯烷酮，吡咯烷-2,5-二酮，吡咯烷和硫代琥珀酰亚胺衍生物，治疗癌症的组合物和方法

    公开(公告)号：US08304425B2

    公开(公告)日：2012-11-06

    申请号：US12664550

    申请日：2008-06-19

    申请人： Jianqiang Wang ,  Syed M. Ali ,  Eugene Kelleher ,  Yanbin Liu ,  Jason Hill ,  Mark A. Ashwell

    发明人： Jianqiang Wang ,  Syed M. Ali ,  Eugene Kelleher ,  Yanbin Liu ,  Jason Hill ,  Mark A. Ashwell

    IPC分类号： A01N43/42 ,  A61K31/44

    CPC分类号： C07D403/14

    摘要： The present invention relates to pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosucciniroide compounds of formulae (I)-(IV), and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosuccinimide compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound of pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosuccinimide compound of the present invention.

    摘要翻译： 本发明涉及式（I） - （IV）的吡咯烷-2-酮，吡咯烷-2,5-二酮，吡咯烷和硫代半胱氨酰化合物及其制备方法。 本发明还涉及包含吡咯烷-2-酮，吡咯烷-2,5-二酮，吡咯烷和硫代琥珀酰亚胺化合物的药物组合物。 本发明提供了治疗细胞增殖性疾病如癌症的方法，通过向有需要的受试者施用治疗有效量的吡咯烷-2-酮，吡咯烷-2,5-二酮，吡咯烷和硫代琥珀酰亚胺的化合物 本发明化合物。

    Substituted pyrazolo-pyrimidine compounds
    9.
    发明授权
    Substituted pyrazolo-pyrimidine compounds 有权
    取代的吡唑并嘧啶化合物

    公开(公告)号：US08343983B2

    公开(公告)日：2013-01-01

    申请号：US12751404

    申请日：2010-03-31

    申请人： Manish Tandon ,  Jianqiang Wang ,  Nivedita Namdev

    发明人： Manish Tandon ,  Jianqiang Wang ,  Nivedita Namdev

    IPC分类号： A01N43/54 ,  A61K31/505 ,  C07D239/00 ,  C07D471/00

    CPC分类号： C07D471/16 ,  C07D487/16

    摘要： The present invention relates to substituted pyrazolo-pyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted pyrazolo-pyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.

    摘要翻译： 本发明涉及取代的吡唑并嘧啶化合物及其合成方法。 本发明还涉及含有取代的吡唑并嘧啶化合物的药物组合物和通过将这些化合物或药物组合物施用于有需要的受试者来治疗细胞增殖性疾病如癌症的方法。