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公开(公告)号:US20060025383A1
公开(公告)日:2006-02-02
申请号:US11050609
申请日:2005-02-03
申请人: Neil Wishart , Michael Friedman , Lee Arnold , Bryant Yang , Shannon Fix-Stenzel , Anna Ericsson , Michael Michaelides , Xiao-Dong Qian , James Holms , Douglas Steinman , Zhengping Tian , Steven Wittenberger
发明人: Neil Wishart , Michael Friedman , Lee Arnold , Bryant Yang , Shannon Fix-Stenzel , Anna Ericsson , Michael Michaelides , Xiao-Dong Qian , James Holms , Douglas Steinman , Zhengping Tian , Steven Wittenberger
IPC分类号: A61K31/5377 , A61K31/519 , A61K31/695 , C07D487/02
CPC分类号: C07D487/04
摘要: A compound of Formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.
摘要翻译: 式(I)的化合物,其中取代基如本文所定义,其可用作激酶抑制剂。
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公开(公告)号:US20060276490A1
公开(公告)日:2006-12-07
申请号:US11464961
申请日:2006-08-16
申请人: Michael Michaelides , Lee Arnold , Michael Curtin , Yujia Dai , Steven Davidsen , Robin Frey , Yan Guo , Zhiqin Ji , Neil Wishart
发明人: Michael Michaelides , Lee Arnold , Michael Curtin , Yujia Dai , Steven Davidsen , Robin Frey , Yan Guo , Zhiqin Ji , Neil Wishart
IPC分类号: A61K31/519 , C07D498/02
CPC分类号: C07D495/04 , C07D513/04
摘要: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译: 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法,含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号:US20060074102A1
公开(公告)日:2006-04-06
申请号:US11129624
申请日:2005-05-13
申请人: Kevin Cusack , Jose-Andres Salmeron-Garcia , Thomas Gordon , Claude Barberis , Hamish Allen , Agniezka Bischoff , Anna Ericsson , Michael Friedman , Dawn George , Gregory Roth , Robert Talanian , Christine Thomas , Grier Wallace , Neil Wishart , Zhengtian Yu
发明人: Kevin Cusack , Jose-Andres Salmeron-Garcia , Thomas Gordon , Claude Barberis , Hamish Allen , Agniezka Bischoff , Anna Ericsson , Michael Friedman , Dawn George , Gregory Roth , Robert Talanian , Christine Thomas , Grier Wallace , Neil Wishart , Zhengtian Yu
IPC分类号: A61K31/4743 , C07D498/02
CPC分类号: C07D471/04 , A61K31/4743 , C07D487/04 , C07D491/04 , C07D495/04 , Y02A50/481
摘要: A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.
摘要翻译: 式(I)的化合物或其药学上可接受的盐,其中取代基如本文所定义,其可用作激酶抑制剂。
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公开(公告)号:US20070282101A1
公开(公告)日:2007-12-06
申请号:US11731950
申请日:2007-04-02
申请人: Anna Ericsson , Andrew Burchat , Kristine Frank , David Calderwood , Lily Abbott , Maria Argiriadi , David Borhani , Kevin Cusack , Richard Dixon , Thomas Gordon , Kelly Mullen , Robert Talanian , Xiaoyun Wu , Xiaolei Zhang , Lu Wang , Biqin Li , Claude Barberis , Neil Wishart
发明人: Anna Ericsson , Andrew Burchat , Kristine Frank , David Calderwood , Lily Abbott , Maria Argiriadi , David Borhani , Kevin Cusack , Richard Dixon , Thomas Gordon , Kelly Mullen , Robert Talanian , Xiaoyun Wu , Xiaolei Zhang , Lu Wang , Biqin Li , Claude Barberis , Neil Wishart
IPC分类号: C07D409/14 , C07D409/04 , C07D413/14
CPC分类号: C07D487/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/14
摘要: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
摘要翻译: 式(I)的新型化合物或其药学上可接受的盐,前体药物和式(I)的生物活性代谢物,其中取代基如本文所定义,其可用作治疗剂。
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公开(公告)号:US08426411B2
公开(公告)日:2013-04-23
申请号:US12958115
申请日:2010-12-01
申请人: Neil Wishart , Kristine E. Frank , Michael Friedman , Dawn M. George , Kent D. Stewart , Grier A. Wallace
发明人: Neil Wishart , Kristine E. Frank , Michael Friedman , Dawn M. George , Kent D. Stewart , Grier A. Wallace
IPC分类号: A61K31/50
CPC分类号: C07D487/14 , A61K31/437 , A61K31/4985 , A61K45/06 , C07D471/14 , C07D498/14 , C07D513/14
摘要: The invention provides compounds of Formula (I) and Formula (II) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译: 本发明提供式(I)和式(II)化合物的药学上可接受的盐,前药,生物活性代谢物,立体异构体和异构体,其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号:US20110190489A1
公开(公告)日:2011-08-04
申请号:US12958291
申请日:2010-12-01
申请人: Neil Wishart , Maria A. Argiriadi , David J. Calderwood , Anna M. Ericsson , Bryan R. Fiamengo , Kristine E. Frank , Michael Friedman , Dawn M. George , Eric R. Goedken , Nathan S. Josephsohn , Biqin C. Li , Michael J. Morytko , Kent D. Stewart , Jeffrey W. Voss , Grier A. Wallace , Lu Wang , Kevin R. Woller , Eric C. Breinlinger , Kelly D. Mullen , Gagandeep Somal
发明人: Neil Wishart , Maria A. Argiriadi , David J. Calderwood , Anna M. Ericsson , Bryan R. Fiamengo , Kristine E. Frank , Michael Friedman , Dawn M. George , Eric R. Goedken , Nathan S. Josephsohn , Biqin C. Li , Michael J. Morytko , Kent D. Stewart , Jeffrey W. Voss , Grier A. Wallace , Lu Wang , Kevin R. Woller , Eric C. Breinlinger , Kelly D. Mullen , Gagandeep Somal
IPC分类号: C07D413/14 , C07D471/14 , C07D487/14 , C07F9/06
CPC分类号: C07F9/06 , C07D471/14 , C07D487/14 , C07D498/14 , C07D513/14
摘要: The invention provides a compound of Formula (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ii), (Ij), (Ik), or (Il) as defined herein, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译: 本发明提供了式(Ia),(Ib),(Ic),(Id),(Ie),(If),(Ig),(Ih),(Ii),(Ij),(Ik) ,或(II),其药学上可接受的盐,前药,生物活性代谢物,立体异构体和异构体,其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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7.Substituted dihydropyrazolo[3,4-D]pyrrolo[2,3-B]pyridines and methods of use thereof 有权
标题翻译: 取代的二氢吡唑并[3,4-D]吡咯并[2,3-b]吡啶及其使用方法公开(公告)号:US08785639B2
公开(公告)日:2014-07-22
申请号:US12958291
申请日:2010-12-01
申请人: Neil Wishart , Maria A. Argiriadi , David J. Calderwood , Anna M. Ericsson , Kristine E. Frank , Dawn M. George , Eric R. Goedken , Michael Friedman , Nathan S. Josephsohn , Biqin C. Li , Michael J. Morytko , Jeffrey W. Voss , Lu Wang , Eric C. Breinlinger , Kelly D. Mullen , Gagandeep Somal , Michael Z Hoemann
发明人: Neil Wishart , Maria A. Argiriadi , David J. Calderwood , Anna M. Ericsson , Kristine E. Frank , Dawn M. George , Eric R. Goedken , Michael Friedman , Nathan S. Josephsohn , Biqin C. Li , Michael J. Morytko , Jeffrey W. Voss , Lu Wang , Eric C. Breinlinger , Kelly D. Mullen , Gagandeep Somal , Michael Z Hoemann
IPC分类号: C07D471/00
CPC分类号: C07F9/06 , C07D471/14 , C07D487/14 , C07D498/14 , C07D513/14
摘要: The invention provides a compound of Formula (Ie), pharmaceutically acceptable salts, or stereoisomers thereof wherein the variables are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译: 本发明提供式(Ie)的化合物,其药学上可接受的盐或立体异构体,其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号:US08754107B2
公开(公告)日:2014-06-17
申请号:US11985724
申请日:2007-11-16
申请人: Dawn M. George , Richard W. Dixon , Michael Friedman , Adrian D. Hobson , Biqin Li , Lu Wang , Xiaoyun Wu , Neil Wishart
发明人: Dawn M. George , Richard W. Dixon , Michael Friedman , Adrian D. Hobson , Biqin Li , Lu Wang , Xiaoyun Wu , Neil Wishart
IPC分类号: A61K31/553 , A61K31/55 , A61K31/5377 , A61K31/506 , A61K31/517 , A61K31/4709 , A61K31/4545 , A61K31/454 , A61K31/4747 , A61K31/438 , A61K31/437 , C07D487/04 , C07D487/10 , C07D487/14 , C07D471/10 , C07D471/04 , C07D417/14 , C07D413/14 , C07D401/14 , C07D401/04
CPC分类号: A61K31/454 , A61K31/437 , A61K31/438 , A61K31/4545 , A61K31/4709 , A61K31/4747 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/55 , A61K31/553 , C07D207/14 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D487/14
摘要: The present invention is directed to novel aminopyrrolidines of formula I pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, stereoisomers thereof or pro-drugs thereof, wherein the variables are as defined herein. The compounds of formula (I) are useful as chemokine receptor antagonists and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
摘要翻译: 本发明涉及式I的药学上可接受的盐的新型氨基吡咯烷,其代谢物,其异构体,其立体异构体或其前体药物,其中变量如本文所定义。 式(I)化合物可用作趋化因子受体拮抗剂,因此可用于治疗某些病症和疾病,特别是炎性病症和疾病以及增殖性疾病和病症,例如癌症。
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公开(公告)号:US20140349970A1
公开(公告)日:2014-11-27
申请号:US14299652
申请日:2014-06-09
申请人: Neil Wishart , Maria A. Argiriadi , Eric C. Breinlinger , David J. Calderwood , Anna M. Ericsson , Bryan A. Fiamengo , Kristine E. Frank , Michael Friedman , Dawn M. George , Eric R. Goedken , Michael Z. Hoemann , Nathan S. Josephsohn , Biqin C. Li , Michael J. Morytko , Kelly D. Mullen , Gagandeep Somal , Kent D. Stewart , Jeffrey W. Voss , Grier A. Wallace , Lu Wang , Kevin R. Woller
发明人: Neil Wishart , Maria A. Argiriadi , Eric C. Breinlinger , David J. Calderwood , Anna M. Ericsson , Bryan A. Fiamengo , Kristine E. Frank , Michael Friedman , Dawn M. George , Eric R. Goedken , Michael Z. Hoemann , Nathan S. Josephsohn , Biqin C. Li , Michael J. Morytko , Kelly D. Mullen , Gagandeep Somal , Kent D. Stewart , Jeffrey W. Voss , Grier A. Wallace , Lu Wang , Kevin R. Woller
IPC分类号: C07F9/06 , C07D487/14 , C07D471/14
CPC分类号: C07F9/06 , C07D471/14 , C07D487/14 , C07D498/14 , C07D513/14
摘要: The invention provides a compound of Formula (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ii), (Ij), (Ik), or (Il) as defined herein, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译: 本发明提供了式(Ia),(Ib),(Ic),(Id),(Ie),(If),(Ig),(Ih),(Ii),(Ij),(Ik) ,或(II),其药学上可接受的盐,前药,生物活性代谢物,立体异构体和异构体,其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号:US20130216497A1
公开(公告)日:2013-08-22
申请号:US13761501
申请日:2013-02-07
申请人: Neil Wishart , Maria A. Argiriadi , David J. Calderwood , Anna M. Ericsson , Bryan A. Fiamengo , Kristine E. Frank , Michael Friedman , Dawn M. George , Eric R. Goedken , Nathan S. Josephsohn , Biqin C. Li , Michael J. Morytko , Kent D. Stewart , Jeffrey W. Voss , Grier A. Wallace , Lu Wang , Kevin R. Woller
发明人: Neil Wishart , Maria A. Argiriadi , David J. Calderwood , Anna M. Ericsson , Bryan A. Fiamengo , Kristine E. Frank , Michael Friedman , Dawn M. George , Eric R. Goedken , Nathan S. Josephsohn , Biqin C. Li , Michael J. Morytko , Kent D. Stewart , Jeffrey W. Voss , Grier A. Wallace , Lu Wang , Kevin R. Woller
IPC分类号: C07D487/14 , A61K45/06 , A61K31/437 , A61K31/4985 , C07D471/14
CPC分类号: C07D487/14 , A61K31/437 , A61K31/4985 , A61K45/06 , C07D471/14 , C07D498/14 , C07D513/14
摘要: The invention provides compounds of Formula (I) and Formula (II) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译: 本发明提供式(I)和式(II)化合物的药学上可接受的盐,前药,生物活性代谢物,立体异构体和异构体,其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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