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    Reference control composition containing a nucleated red blood cell component made of non-nucleated blood cells
    1.
    发明授权
    Reference control composition containing a nucleated red blood cell component made of non-nucleated blood cells 有权
    含有由无核血细胞制成的有核红细胞成分的参照对照组合物

    公开(公告)号：US07354767B2

    公开(公告)日：2008-04-08

    申请号：US11377171

    申请日：2006-03-16

    申请人： Nery Ortiz ,  Theodore J. Gerula ,  Sandra Socarras

    发明人： Nery Ortiz ,  Theodore J. Gerula ,  Sandra Socarras

    IPC分类号： G01N33/48 ,  G01N31/00

    CPC分类号： G01N33/96 ,  G01N15/1012 ,  G01N15/12 ,  G01N15/147 ,  G01N2015/1037 ,  G01N2496/05 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/107497 ,  Y10T436/25 ,  Y10T436/2525

    摘要： A reference control composition containing a nucleated red blood cell component and the method of making are disclosed. The reference control composition includes a nucleated red blood cell component made of fixed non-nucleated blood cells and a suspension medium. The non-nucleated blood cell has a natural cell size substantially similar to a size of nucleus of said nucleated red blood cell of said blood sample. The nucleated red blood cell component can be made of equine, ovine, bovine, feline, canine, or porcine red blood cells; and it is substantially free of nucleic acid. The reference control composition can further include a white blood cell component, a red blood cell component, a platelet component, a reticulocyte component, or combinations thereof. Further disclosed are the methods of using the reference control composition for measurement of nucleated red blood cells on a blood analyzer.

    摘要翻译： 公开了含有有核红细胞成分的参照对照组合物及其制造方法。 参考对照组合物包含由固定的无核血细胞和悬浮介质制成的有核红细胞成分。 非成核血细胞具有与所述血液样品的所述有核红细胞的核的大小基本相似的天然细胞大小。 有核红细胞成分可以由马，羊，牛，猫，犬或猪红细胞组成; 并且其基本上不含核酸。 参考对照组合物还可包含白细胞成分，红细胞成分，血小板成分，网状细胞成分或其组合。 还公开了使用参考对照组合物测量血液分析仪上的有核红细胞的方法。

    Hematology linearity control composition, system and method of use
    2.
    发明授权
    Hematology linearity control composition, system and method of use 有权
    血液学线性控制组成，系统和使用方法

    公开(公告)号：US07754487B2

    公开(公告)日：2010-07-13

    申请号：US11938853

    申请日：2007-11-13

    申请人： Nery Ortiz ,  Theodore J. Gerula

    发明人： Nery Ortiz ,  Theodore J. Gerula

    IPC分类号： G01N33/48

    CPC分类号： G01N33/96 ,  G01N15/12 ,  G01N2015/1006 ,  G01N2496/10 ,  Y10T436/10 ,  Y10T436/101666

    摘要： A linearity control system includes a series of linearity control compositions, each thereof includes white blood cell analogs and stabilized red blood cells in a suspension medium. The concentration of the white blood cell analogs in the series of control compositions increases from 0.2×103 to 800×103 analogs per microliter, and the concentration of the white blood cell analogs in at least one control composition is greater than 120×103 analogs per microliter. The stabilized red blood cells facilitate mono-dispersion of the white blood cell analogs in the suspension medium by gently mixing. The control compositions further include platelet analogs, or additionally include reticulocyte and/or nucleated red blood cell analogs. The linearity control system allows the verification of the reportable measurement range and linearity of the measurements of hematology analyzers for white blood cells, red blood cells and platelets in extended concentration ranges.

    摘要翻译： 线性控制系统包括一系列线性控制组合物，其中每一个包括悬浮介质中的白细胞类似物和稳定的红细胞。 一系列对照组合物中白细胞类似物的浓度从0.2×103增加到800×103类似物/微升，并且至少一种对照组合物中白细胞类似物的浓度大于每个对照组合物的120×103个类似物 微升。 稳定的红细胞促进白细胞类似物在悬浮介质中的单分散，通过轻轻混合。 对照组合物还包括血小板类似物，或另外包括网织红细胞和/或有核红细胞类似物。 线性控制系统允许验证可扩展浓度范围内白细胞，红细胞和血小板的血液分析仪的可报告测量范围和线性度。

    Hematology Linearity Control Composition, System and Method of Use
    3.
    发明申请
    Hematology Linearity Control Composition, System and Method of Use 有权
    血液学线性控制组成，系统和使用方法

    公开(公告)号：US20080113438A1

    公开(公告)日：2008-05-15

    申请号：US11938853

    申请日：2007-11-13

    申请人： Nery Ortiz ,  Theodore J. Gerula

    发明人： Nery Ortiz ,  Theodore J. Gerula

    IPC分类号： G01N33/48 ,  G01N37/00

    CPC分类号： G01N33/96 ,  G01N15/12 ,  G01N2015/1006 ,  G01N2496/10 ,  Y10T436/10 ,  Y10T436/101666

    摘要： A linearity control system includes a series of linearity control compositions, each thereof includes white blood cell analogs and stabilized red blood cells in a suspension medium. The concentration of the white blood cell analogs in the series of control compositions increases from 0.2×103 to 800×103 analogs per microliter, and the concentration of the white blood cell analogs in at least one control composition is greater than 120×103 analogs per microliter. The stabilized red blood cells facilitate mono-dispersion of the white blood cell analogs in the suspension medium by gently mixing. The control compositions further include platelet analogs, or additionally include reticulocyte and/or nucleated red blood cell analogs. The linearity control system allows the verification of the reportable measurement range and linearity of the measurements of hematology analyzers for white blood cells, red blood cells and platelets in extended concentration ranges.

    摘要翻译： 线性控制系统包括一系列线性控制组合物，其中每一个包括悬浮介质中的白细胞类似物和稳定的红细胞。 一系列对照组合物中白细胞类似物的浓度从每微升升至0.2×10 3至800×10 3个类似物，并且白细胞类似物的浓度在 至少一种对照组合物每微升大于120×10 3个类似物。 稳定的红细胞促进白细胞类似物在悬浮介质中的单分散，通过轻轻混合。 对照组合物还包括血小板类似物，或另外包括网织红细胞和/或有核红细胞类似物。 线性控制系统允许验证可扩展浓度范围内白细胞，红细胞和血小板的血液分析仪的可报告测量范围和线性度。

    Method of using a hematology reference control for measurement of immature granulocytes
    4.
    发明授权
    Method of using a hematology reference control for measurement of immature granulocytes 有权
    使用血液学参考对照测量未成熟粒细胞的方法

    公开(公告)号：US07393688B2

    公开(公告)日：2008-07-01

    申请号：US11495056

    申请日：2006-07-28

    申请人： Nery Ortiz ,  Theodore J. Gerula ,  Yi Li

    发明人： Nery Ortiz ,  Theodore J. Gerula ,  Yi Li

    IPC分类号： G01N31/00

    CPC分类号： G01N33/96 ,  G01N15/12 ,  G01N2015/1006 ,  Y10S435/967 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/106664

    摘要： A method of using a reference control for measurement of immature granulocytes on a blood analyzer is disclosed. The method includes analyzing a reference control that contains an immature granulocyte component made of processed red blood cells for simulating immature granulocytes and a mature white blood cell component for simulating white blood cells of a blood sample on a blood analyzer adapted for measurement of immature granulocytes, and reporting the immature granulocyte component and the mature white blood cell component of the reference control.

    摘要翻译： 公开了一种在血液分析仪上使用参考对照测量未成熟粒细胞的方法。 该方法包括分析包含由用于模拟未成熟粒细胞的加工红细胞制成的未成熟粒细胞成分的参照对照和用于模拟适于测量未成熟粒细胞的血液分析仪上的血液样品的白细胞的成熟白细胞成分， 并报告参考对照的未成熟粒细胞成分和成熟白细胞成分。

    Hematology reference control containing an immature granulocyte component
    6.
    发明授权
    Hematology reference control containing an immature granulocyte component 有权
    包含未成熟粒细胞成分的血液学参考对照

    公开(公告)号：US07109036B2

    公开(公告)日：2006-09-19

    申请号：US10845557

    申请日：2004-05-13

    申请人： Nery Ortiz ,  Theodore J. Gerula ,  Yi Li

    发明人： Nery Ortiz ,  Theodore J. Gerula ,  Yi Li

    IPC分类号： G01N31/00

    CPC分类号： G01N33/96 ,  G01N15/12 ,  G01N2015/1006 ,  Y10S435/967 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/106664

    摘要： A hematology reference control containing an immature granulocyte component and the method of making are disclosed. The reference control includes an immature granulocyte component made of processed blood cells for simulating human immature granulocytes, and a suspension medium suitable for delivering the component to a blood analyzer for measurement of immature granulocytes. The immature granulocyte component can be made of processed avian, reptile or fish red blood cells, or human immature granulocytes produced in vitro. The reference control further includes a white blood cell component which includes white blood cell sub-components for simulating white blood subpopulations. Further disclosed is the method of using the reference control for measurement of immature granulocytes on a blood analyzer.

    摘要翻译： 公开了含有未成熟粒细胞成分的血液学参考对照和制备方法。 参考对照包括由用于模拟人类未成熟粒细胞的加工血细胞制成的未成熟粒细胞组分和适于将组分输送到用于测量未成熟粒细胞的血液分析仪的悬浮培养基。 未成熟的粒细胞组分可以由加工的禽，爬行动物或鱼红细胞或体外产生的人类未成熟粒细胞制成。 参考对照还包括白血球成分，其包括用于模拟白血球亚群的白细胞亚组分。 进一步公开了使用参考对照在血液分析仪上测量未成熟粒细胞的方法。

    Hematology control compositions for three populations of leukocytes; and methods for their preparation and use in whole blood control systems
    9.
    发明授权
    Hematology control compositions for three populations of leukocytes; and methods for their preparation and use in whole blood control systems 失效
    三个白细胞群的血液学控制组合物; 及其在全血控制系统中的制备和使用方法

    公开(公告)号：US4704364A

    公开(公告)日：1987-11-03

    申请号：US612091

    申请日：1984-05-18

    申请人： Franklin J. Carver ,  Theodore J. Gerula

    发明人： Franklin J. Carver ,  Theodore J. Gerula

    IPC分类号： G01N33/48 ,  G01N33/96 ,  G01N31/00

    CPC分类号： G01N33/96 ,  G01N2496/05 ,  Y10T436/101666 ,  Y10T436/105831 ,  Y10T436/106664 ,  Y10T436/107497 ,  Y10T436/108331

    摘要： This invention primarily is directed to a hematology reference control solution, the three separate white cell control portions thereof consisting of three types of fixed red cells of determined size distribution for checking the operation of a particle analyzing instrument, including its predetermined lower and upper threshold settings for each class or subclass of leukocytes.For preparing a human granulocyte analogue, nurse shark erythrocytes are altered and fixed in a chilled solution to simulate in number, size and distribution the granulocytes in human whole blood.Such a granulocyte analogue is useful as a free-standing reference control, for determination of human granulocytes only, or can be comingled with reference controls for lymphocytes and mononuclear cells for use with multi-parameter instruments to give a trimodal leukocyte reference control, which itself can be included in a multiple-analysis hematology reference control, having components for also determining red blood cell and platelet parameters.

    摘要翻译： 本发明主要针对血液学参考对照溶液，其三个单独的白细胞控制部分由三种类型的具有确定尺寸分布的固定红细胞组成，用于检查颗粒分析仪器的操作，包括其预定的下限和上限阈值设置 对于白细胞的每一类或亚类。 为了制备人粒细胞类似物，将护士鲨鱼红细胞改变并固定在冷冻溶液中以模拟人全血中的粒细胞的数量，大小和分布。 这样的粒细胞类似物可用作独立的参考对照，仅用于测定人粒细胞，或可以用淋巴细胞和单核细胞的参照对照随机使用多参数仪器，以得到三体白细胞参照对照，其本身 可以包括在多分析血液学参考对照中，其具有用于还测定红细胞和血小板参数的成分。