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1.发明授权Apparatus for simulating the deformation of materials, notably of soft body tissues 有权用于模拟材料变形的装置，特别是软体组织的变形公开(公告)号：US07239992B2
公开(公告)日：2007-07-03
申请号：US10061455
申请日：2002-02-04
摘要： The invention relates to the simulation of the deformation of materials, notably of soft body tissues. An apparatus comprises a memory (MEM, NT) storing data as to the position of an object, recorded at the vertices of a grid pattern, and data for force to be exerted on the object. A computer (μP, MT) evaluates new positions of the vertices, as a function of a force exerted globally and mechanical parameters of the material. According to the invention, this computer comprises a module for calculating, for each mesh, a deviation between the current length of an edge and its previous length, and the force data at each vertex of the mesh. Another module calculates, for each vertex, new positional data relating to this vertex as a function of the forces exerted thereon and its previous position.
摘要翻译： 本发明涉及材料变形的模拟，特别是软体组织的变形。 存储器（MEM，NT）存储关于记录在网格图案的顶点的物体的位置的数据，以及用于施加在物体上的力的数据。 计算机（muP，MT）根据全局施加的力和材料的机械参数来评估顶点的新位置。 根据本发明，该计算机包括用于针对每个网格计算边缘的当前长度与其先前长度之间的偏差以及网格的每个顶点处的力数据的模块。 另一个模块针对每个顶点计算与该顶点相关的新位置数据，作为施加于其上的力及其先前位置的函数。
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2.发明申请公开(公告)号：US20140136174A1
公开(公告)日：2014-05-15
申请号：US14071688
申请日：2013-11-05
申请人： Chloe Audigier , Tommaso Mansi , Viorel Mihalef , Ali Kamen , Dorin Comaniciu , Puneet Sharma , Saikiran Rapaka , Herve Delingette , Nicholas Ayache
发明人： Chloe Audigier , Tommaso Mansi , Viorel Mihalef , Ali Kamen , Dorin Comaniciu , Puneet Sharma , Saikiran Rapaka , Herve Delingette , Nicholas Ayache
IPC分类号： G06F19/12
CPC分类号： G16H50/50 , G06F19/00 , G06F19/3481 , G09B23/30
摘要： A method and system for tumor ablation planning and guidance based on a patient-specific model of liver tumor ablation is disclosed. A patient-specific anatomical model of the liver and circulatory system of the liver is estimated from 3D medical image data of a patient. Blood flow in the liver and the circulatory system of the liver is simulated based on the patient-specific anatomical model. Heat diffusion due to ablation is simulated based on a virtual ablation probe position and the simulated blood flow in the liver and the venous system of the liver. Cellular necrosis in the liver is simulated based on the simulated heat diffusion. A visualization of a simulated necrosis region is generated and displayed to the user for decision making and optimal therapy planning and guidance.
摘要翻译： 公开了一种基于肝肿瘤消融的患者特异性模型的肿瘤消融计划和指导的方法和系统。 根据患者的3D医学图像数据估计肝脏和肝脏循环系统的患者特异性解剖模型。 根据患者特异性解剖模型模拟肝脏和肝脏循环系统的血流。 基于虚拟消融探针位置和肝脏和肝脏静脉系统中的模拟血流模拟了消融引起的热扩散。 基于模拟热扩散模拟肝脏细胞坏死。 生成模拟坏死区域的可视化，并向用户显示决策和最佳治疗计划和指导。
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公开(公告)号：US09846765B2
公开(公告)日：2017-12-19
申请号：US14071688
申请日：2013-11-05
申请人： Chloe Audigier , Tommaso Mansi , Viorel Mihalef , Ali Kamen , Dorin Comaniciu , Puneet Sharma , Saikiran Rapaka , Herve Delingette , Nicholas Ayache
发明人： Chloe Audigier , Tommaso Mansi , Viorel Mihalef , Ali Kamen , Dorin Comaniciu , Puneet Sharma , Saikiran Rapaka , Herve Delingette , Nicholas Ayache
CPC分类号： G16H50/50 , G06F19/00 , G06F19/3481 , G09B23/30
摘要： A method and system for tumor ablation planning and guidance based on a patient-specific model of liver tumor ablation is disclosed. A patient-specific anatomical model of the liver and circulatory system of the liver is estimated from 3D medical image data of a patient. Blood flow in the liver and the circulatory system of the liver is simulated based on the patient-specific anatomical model. Heat diffusion due to ablation is simulated based on a virtual ablation probe position and the simulated blood flow in the liver and the venous system of the liver. Cellular necrosis in the liver is simulated based on the simulated heat diffusion. A visualization of a simulated necrosis region is generated and displayed to the user for decision making and optimal therapy planning and guidance.
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4.发明授权Robust mosaicing method, notably with correction of motion distortions and tissue deformations for a vivo fibered microscopy 有权强大的镶嵌方法，特别是对于体内纤维显微镜的运动失真和组织变形的校正公开(公告)号：US08218901B2
公开(公告)日：2012-07-10
申请号：US13178688
申请日：2011-07-08
CPC分类号： G06K9/00134 , G02B21/367 , G06T3/4038 , G06T7/35 , G06T2207/10056
摘要： A method for mosaicing frames from a video sequence is disclosed. Each frame is constituted by a point cloud, and each point in the point cloud is potentially acquired at a different time. The method involves compensating for motion and motion distortion due to acquisition time differences in each frame, applying a global optimization of inter-frame registration to align consistently the frames, and applying a reconstruction algorithm on the registered frames to construct a mosaic.
摘要翻译： 公开了一种从视频序列拼接帧的方法。 每个帧由点云构成，并且点云中的每个点可能在不同的时间被获取。 该方法包括补偿由于每帧中的采集时间差引起的运动和运动失真，应用帧间配准的全局优化以一致地对准帧，并且在注册的帧上应用重建算法来构建马赛克。
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5.发明授权Robust mosaicing method, notably with correction of motion distortions and tissue deformations for in vivo fibered microscopy 有权强大的镶嵌方法，特别是用于体内纤维显微镜的运动失真和组织变形的校正公开(公告)号：US07978932B2
公开(公告)日：2011-07-12
申请号：US11832674
申请日：2007-08-02
CPC分类号： G06K9/00134 , G02B21/367 , G06T3/4038 , G06T7/35 , G06T2207/10056
摘要： A mosaicing method taking into account motion distortions, irregularly sampled frames and non-rigid deformations of the imaged tissue. The method for mosaicing frames from a video sequence acquired from a scanning device such as a scanning microscope, includes the steps of: a) compensating for motion and motion distortion due to the scanning microscope, b) applying a global optimization of inter-frame registration to align consistently the frames c) applying a construction algorithm on the registered frames to construct a mosaic, and d) applying a fine frame-to-mosaic non rigid registration. The method is based on a hierarchical framework that is able to recover a globally consistent alignment of the input frames, to compensate for the motion distortions and to capture the non-rigid deformations.
摘要翻译： 考虑到运动失真，不规则采样帧和成像组织的非刚性变形的镶嵌方法。 从诸如扫描显微镜的扫描装置获取的视频序列拼接帧的方法包括以下步骤：a）补偿由扫描显微镜引起的运动和运动失真，b）应用帧间对准的全局优化 以一致地对准帧c）在注册的帧上应用构造算法以构建马赛克，以及d）应用精细的帧到马赛克非刚性注册。 该方法基于能够恢复输入帧的全局一致对齐的分层框架，以补偿运动失真并捕获非刚性变形。
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6.发明申请ROBUST MOSAICING METHOD. NOTABLY WITH CORRECTION OF MOTION DISTORTIONS AND TISSUE DEFORMATIONS FOR A VIVO FIBERED MICROSCOPY 有权鲁棒的莫斯科方法。 不适用于运动失真校正和组织变形的体细胞纤维化公开(公告)号：US20090041314A1
公开(公告)日：2009-02-12
申请号：US11832674
申请日：2007-08-02
IPC分类号： G06K9/00
CPC分类号： G06K9/00134 , G02B21/367 , G06T3/4038 , G06T7/35 , G06T2207/10056
摘要： The present invention concerns a mosaicing method taking into account motion distortions, irregularly sampled frames and non-rigid deformations of the imaged tissue. The invention relates to a method for mosaicing frames from a video sequence acquired from a scanning device such as a scanning microscope, the method comprising the steps of: a) compensating for motion and motion distortion due to the scanning microscope, b) applying a global optimisation of inter-frame registration to align consistently the frames c) applying a construction algorithm on the registered frames to construct a mosaic, and d) applying a fine frame-to-mosaic non rigid registration. The method is based on a hierarchical framework that is able to recover a globally consistent alignment of the input frames, to compensate for the motion distortions and to capture the non-rigid deformations.
摘要翻译： 本发明涉及考虑到成像组织的运动失真，不规则采样帧和非刚性变形的镶嵌方法。 本发明涉及一种用于从诸如扫描显微镜的扫描装置获取的视频序列拼接帧的方法，所述方法包括以下步骤：a）补偿由扫描显微镜引起的运动和运动失真，b）应用全局 框架间注册的优化以一致地对准帧c）在注册的帧上应用构造算法以构建马赛克，以及d）应用精细的帧到马赛克非刚性注册。 该方法基于能够恢复输入帧的全局一致对齐的分层框架，以补偿运动失真并捕获非刚性变形。
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7.发明授权Electronic device for processing image-data, for simulating the behaviour of a deformable object 有权用于处理图像数据的电子设备，用于模拟可变形对象的行为公开(公告)号：US06714901B1
公开(公告)日：2004-03-30
申请号：US09341651
申请日：1999-07-16
IPC分类号： G06G748
CPC分类号： G06F3/011 , B25J9/1689 , G05B19/4097
摘要： An electronic device for processing image data, particularly image data pertaining to medical procedures, includes a user interface with force feedback (4) corresponding to tool reactions, a “collision” module (18) for estimating a point of intersection between a straight line embodying a displacement derived from the action of the tool and a surface mesh of a given object, and an internal forces module (16) which estimates internal forces exerted on nodes of a first part of at least a volume mesh of the object, on the basis of a displacement applied on nodes pertaining to the surface mesh containing a point of intersection, of boundary conditions, and of node tensors and link tensors, from matrices of rigidity, and a reaction module (20) for determining the reaction force of the object corresponding to its deformation estimated on the basis of the internal forces, such that the force generated by the user interface (4) is balanced by reaction force.
摘要翻译： 一种用于处理图像数据的电子设备，特别是与医疗程序有关的图像数据，包括具有对应于工具反应的力反馈（4）的用户接口，“冲突”模块（18），用于估计体现 根据工具的作用和给定物体的表面网格产生的位移，以及内力部件（16），其基于对象的至少一个体积网格的第一部分的节点上的内力来估计内力 在与包含交点，边界条件以及节点张量和连接张量的表面网格相关联的节点上的位移应用于刚度矩阵，以及用于确定对象的反作用力的反应模块（20） 基于内力估计其变形，使得由用户界面（4）产生的力由反作用力平衡。
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公开(公告)号：US06539127B1
公开(公告)日：2003-03-25
申请号：US09361313
申请日：1999-07-27
IPC分类号： G06K932
CPC分类号： G06T3/4061
摘要： An electronic data processing device receives first and second data sets representing first and second comparable digital images. It comprises registration means comprising a first module which calculates a main function representative of the correlation ratios between the data of the first and second sets, and a second module which determines a registration transformation between one of the images and the other from the main function.
摘要翻译： 电子数据处理装置接收表示第一和第二可比数字图像的第一和第二数据集。 它包括注册装置，包括第一模块，其计算表示第一和第二组数据之间的相关比的主要功能;以及第二模块，其从主要功能确定一个图像与另一个之间的配准转换。
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9.发明申请ROBUST MOSAICING METHOD, NOTABLY WITH CORRECTION OF MOTION DISTORTIONS AND TISSUE DEFORMATIONS FOR A VIVO FIBERED MICROSCOPY 有权稳定的MOSAICING方法，可以修正运动失真和VIVO FIBERED MICROSCOPY的组织变形公开(公告)号：US20110261262A1
公开(公告)日：2011-10-27
申请号：US13178688
申请日：2011-07-08
IPC分类号： H04N5/00
CPC分类号： G06K9/00134 , G02B21/367 , G06T3/4038 , G06T7/35 , G06T2207/10056
摘要： The present invention concerns a mosaicing method taking into account motion distortions, irregularly sampled frames and non-rigid deformations of the imaged tissue. The invention relates to a method for mosaicing frames from a video sequence acquired from a scanning device such as a scanning microscope, the method comprising the steps of: a) compensating for motion and motion distortion due to the scanning microscope, b) applying a global optimisation of inter-frame registration to align consistently the frames c) applying a construction algorithm on the registered frames to construct a mosaic, and d) applying a fine frame-to-mosaic non rigid registration. The method is based on a hierarchical framework that is able to recover a globally consistent alignment of the input frames, to compensate for the motion distortions and to capture the non-rigid deformations.
摘要翻译： 本发明涉及考虑到成像组织的运动失真，不规则采样帧和非刚性变形的镶嵌方法。 本发明涉及一种用于从诸如扫描显微镜的扫描装置获取的视频序列拼接帧的方法，所述方法包括以下步骤：a）补偿由扫描显微镜引起的运动和运动失真，b）应用全局 框架间注册的优化以一致地对准帧c）在注册的帧上应用构造算法以构建马赛克，以及d）应用精细的帧到马赛克非刚性注册。 该方法基于能够恢复输入帧的全局一致对齐的分层框架，以补偿运动失真并捕获非刚性变形。
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公开(公告)号：US07822240B2
公开(公告)日：2010-10-26
申请号：US10492015
申请日：2002-10-04
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/30 , G06T2207/10072 , G06T2207/30016
摘要： The invention concerns an image processing device, including an input for receiving a time series of data sets representing comparable volume digital images, each data having a position component and an intensity component, pre-processing means for modifying the data sets so as to obtain images updated in position and intensity, and comparative processing means for examining sets of time series of image elements and to detect therein signs of variations. The processing means include a modeling function for adjusting a parametric model separately on some of the sets of time series of image elements, to obtain pairs of data (image element, time) and a function for statistical analysis of said pairs of data to isolate the pairs of data representing a significant variation.
摘要翻译： 本发明涉及一种图像处理装置，其包括用于接收表示可比较的体数字图像的数据集的时间序列的输入，每个数据具有位置分量和强度分量，用于修改数据集以获得图像的预处理装置 更新的位置和强度，以及比较处理装置，用于检查图像元素的时间序列集合并在其中检测变化的迹象。 处理装置包括用于在一些时间序列的图像元素的一些集合上单独调整参数模型的建模功能，以获得数据对（图像元素，时间）和用于所述数据对的统计分析的功能，以隔离 成对的数据表示显着的变化。
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