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公开(公告)号：US08597906B2
公开(公告)日：2013-12-03
申请号：US13094606
申请日：2011-04-26
申请人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
发明人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
CPC分类号： C12N9/2488 , A61K38/00 , C07K14/00 , C12N9/1051 , C12N9/24 , C12N9/2402 , C12N9/2465 , C12P21/005 , C12P21/06 , C12Y204/01232 , C12Y302/01024 , C12Y302/01045 , C12Y302/01046 , C12Y302/01084 , C12Y302/01113 , Y02P20/52
摘要： Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
摘要翻译： 本文描述了可用于产生改变的N-糖基化形式的靶分子的方法和遗传工程改造的细胞。 还描述了具有改变的N-糖基化的方法和分子，其可用于治疗各种疾病如代谢紊乱。
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公开(公告)号：US10023854B2
公开(公告)日：2018-07-17
申请号：US13620259
申请日：2012-09-14
申请人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
发明人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
摘要： Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
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公开(公告)号：US09206408B2
公开(公告)日：2015-12-08
申请号：US13620306
申请日：2012-09-14
申请人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
发明人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
IPC分类号： A61K38/16 , C12N9/24 , C12N9/10 , C12P21/00 , C07K14/00 , C12N9/40 , C12P21/06 , C07K14/39 , A61K38/00
CPC分类号： C12N9/2488 , A61K38/00 , C07K14/00 , C12N9/1051 , C12N9/24 , C12N9/2402 , C12N9/2465 , C12P21/005 , C12P21/06 , C12Y204/01232 , C12Y302/01024 , C12Y302/01045 , C12Y302/01046 , C12Y302/01084 , C12Y302/01113 , Y02P20/52
摘要： Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
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公开(公告)号：US20130195835A1
公开(公告)日：2013-08-01
申请号：US13620259
申请日：2012-09-14
申请人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
发明人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
CPC分类号： C12N9/2488 , A61K38/00 , C07K14/00 , C12N9/1051 , C12N9/24 , C12N9/2402 , C12N9/2465 , C12P21/005 , C12P21/06 , C12Y204/01232 , C12Y302/01024 , C12Y302/01045 , C12Y302/01046 , C12Y302/01084 , C12Y302/01113 , Y02P20/52
摘要： Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
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公开(公告)号：US20130190253A1
公开(公告)日：2013-07-25
申请号：US13620306
申请日：2012-09-14
申请人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
发明人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
IPC分类号： C07K14/00
CPC分类号： C12N9/2488 , A61K38/00 , C07K14/00 , C12N9/1051 , C12N9/24 , C12N9/2402 , C12N9/2465 , C12P21/005 , C12P21/06 , C12Y204/01232 , C12Y302/01024 , C12Y302/01045 , C12Y302/01046 , C12Y302/01084 , C12Y302/01113 , Y02P20/52
摘要： Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
摘要翻译： 本文描述了可用于产生改变的N-糖基化形式的靶分子的方法和遗传工程改造的细胞。 还描述了具有改变的N-糖基化的方法和分子，其可用于治疗各种疾病如代谢紊乱。
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6.发明授权Microorganisms genetically engineered to have modified N-glycosylation activity 有权遗传工程改造为具有修饰的N-糖基化活性的微生物公开(公告)号：US09222083B2
公开(公告)日：2015-12-29
申请号：US13095532
申请日：2011-04-27
申请人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
发明人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
IPC分类号： A61K38/16 , C12N9/24 , C12N9/10 , C12P21/00 , C07K14/00 , C12N9/40 , C12P21/06 , C07K14/39 , A61K38/00
CPC分类号： C12N9/2488 , A61K38/00 , C07K14/00 , C12N9/1051 , C12N9/24 , C12N9/2402 , C12N9/2465 , C12P21/005 , C12P21/06 , C12Y204/01232 , C12Y302/01024 , C12Y302/01045 , C12Y302/01046 , C12Y302/01084 , C12Y302/01113 , Y02P20/52
摘要： Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
摘要翻译： 本文描述了可用于产生改变的N-糖基化形式的靶分子的方法和遗传工程改造的细胞。 还描述了具有改变的N-糖基化的方法和分子，其可用于治疗各种疾病如代谢紊乱。
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公开(公告)号：US08026083B2
公开(公告)日：2011-09-27
申请号：US12062469
申请日：2008-04-03
申请人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
发明人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
CPC分类号： C12N9/2488 , A61K38/00 , C07K14/00 , C12N9/1051 , C12N9/24 , C12N9/2402 , C12N9/2465 , C12P21/005 , C12P21/06 , C12Y204/01232 , C12Y302/01024 , C12Y302/01045 , C12Y302/01046 , C12Y302/01084 , C12Y302/01113 , Y02P20/52
摘要： Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
摘要翻译： 本文描述了可用于产生改变的N-糖基化形式的靶分子的方法和遗传工程改造的细胞。 还描述了具有改变的N-糖基化的方法和分子，其可用于治疗各种疾病如代谢紊乱。
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公开(公告)号：US20110207676A1
公开(公告)日：2011-08-25
申请号：US13095532
申请日：2011-04-27
申请人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
发明人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
IPC分类号： A61K38/16 , C12P21/00 , C12N9/24 , C12N9/38 , C12N9/40 , C12N9/26 , C12N9/10 , C12N9/12 , C12N9/20 , C12N9/16 , C12N9/96 , C12N1/19 , C07K14/00 , A61P35/00
CPC分类号： C12N9/2488 , A61K38/00 , C07K14/00 , C12N9/1051 , C12N9/24 , C12N9/2402 , C12N9/2465 , C12P21/005 , C12P21/06 , C12Y204/01232 , C12Y302/01024 , C12Y302/01045 , C12Y302/01046 , C12Y302/01084 , C12Y302/01113 , Y02P20/52
摘要： Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
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公开(公告)号：US20110201540A1
公开(公告)日：2011-08-18
申请号：US13094606
申请日：2011-04-26
申请人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
发明人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
CPC分类号： C12N9/2488 , A61K38/00 , C07K14/00 , C12N9/1051 , C12N9/24 , C12N9/2402 , C12N9/2465 , C12P21/005 , C12P21/06 , C12Y204/01232 , C12Y302/01024 , C12Y302/01045 , C12Y302/01046 , C12Y302/01084 , C12Y302/01113 , Y02P20/52
摘要： Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
摘要翻译： 本文描述了可用于产生改变的N-糖基化形式的靶分子的方法和遗传工程改造的细胞。 还描述了具有改变的N-糖基化的方法和分子，其可用于治疗各种疾病如代谢紊乱。
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公开(公告)号：US20090069232A1
公开(公告)日：2009-03-12
申请号：US12062469
申请日：2008-04-03
申请人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
发明人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
CPC分类号： C12N9/2488 , A61K38/00 , C07K14/00 , C12N9/1051 , C12N9/24 , C12N9/2402 , C12N9/2465 , C12P21/005 , C12P21/06 , C12Y204/01232 , C12Y302/01024 , C12Y302/01045 , C12Y302/01046 , C12Y302/01084 , C12Y302/01113 , Y02P20/52
摘要： Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
摘要翻译： 本文描述了可用于产生改变的N-糖基化形式的靶分子的方法和遗传工程改造的细胞。 还描述了具有改变的N-糖基化的方法和分子，其可用于治疗各种疾病如代谢紊乱。
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