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公开(公告)号：US20080049994A1
公开(公告)日：2008-02-28
申请号：US11659887
申请日：2005-08-05
IPC分类号： G06K9/00
CPC分类号： G06T7/35 , G06T2207/30048
摘要： An image registration method for use in medical imaging is proposed. The method includes the steps of: providing a sequence of images each one including a digital representation of a body-part under analysis, selecting a reference image within the sequence, the remaining images of the sequence defining moving images, and re-aligning at least one portion of a moving image with respect to the reference image. The step of re-aligning includes: defining a delimitation mask identifying a region on the reference image with which the at least one portion of the moving image has to be re-aligned, and a feature mask identifying a further region on the reference image within which the re-alignment is calculated, determining an optimized transformation for compensating a displacement of the moving image with respect to the reference image by optimizing a similarity measure, and transforming the at least one portion of the moving image according to the optimized transformation. The similarity measure is calculated alternatively between: a) a first computation region identified on the reference image by a computation mask and a second computation region identified by the computation mask on the moving image transformed according to a proposed transformation, the computation mask being determined by the intersection between the feature mask and the delimitation mask transformed according to the proposed transformation, or b) a first computation region identified by a computation mask on the reference image transformed according to a proposed transformation and a second computation region identified by the computation mask on the moving image, the computation mask being determined by the intersection between the feature mask transformed according to the proposed transformation and the delimitation mask, or c) a first computation region identified on the reference image by a computation mask transformed according to the reverse of a proposed transformation and a second computation region identified by the computation mask on the moving image, the computation mask being determined by the intersection between the feature mask transformed according to the proposed transformation and the delimitation mask.
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2.发明授权Image registration method and apparatus for medical imaging based on multiple masks 有权基于多个掩模的医学成像的图像配准方法和装置公开(公告)号：US07912259B2
公开(公告)日：2011-03-22
申请号：US11659887
申请日：2005-08-05
IPC分类号： G06K9/00
CPC分类号： G06T7/35 , G06T2207/30048
摘要： An image registration method for use in medical imaging includes the steps of: providing a sequence of images each one including a digital representation of a body-part under analysis, selecting a reference image within the sequence, the remaining images of the sequence defining moving images, and re-aligning at least one portion of a moving image with respect to the reference image. The step of re-aligning may include: defining a delimitation mask identifying a region on the reference image with which the at least one portion of the moving image has to be re-aligned, and a feature mask identifying a further region on the reference image within which the re-alignment is calculated, determining an optimized transformation for compensating a displacement of the moving image with respect to the reference image by optimizing a similarity measure, and transforming the at least one portion of the moving image according to the optimized transformation.
摘要翻译： 用于医学成像的图像配准方法包括以下步骤：提供每个图像序列，每个图像序列包括正在分析的身体部位的数字表示，选择序列内的参考图像，定义运动图像的序列的剩余图像 并且相对于参考图像重新对准运动图像的至少一部分。 重新对准的步骤可以包括：定义标识在参考图像上必须重新对齐运动图像的至少一部分的参考图像上的区域的定界掩模，以及标识参考图像上的另外区域的特征掩模 在其中计算重新对准，通过优化相似性度量来确定用于补偿运动图像相对于参考图像的位移的优化变换，以及根据优化的变换来变换运动图像的至少一部分。
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3.发明申请公开(公告)号：US20090304593A1
公开(公告)日：2009-12-10
申请号：US12520839
申请日：2007-12-21
CPC分类号： G01S7/52041 , A61B8/481 , G01S7/52026 , G01S7/52038 , G01S7/52071 , G01S7/52074
摘要： An embodiment of a solution is proposed for imaging a body-part that is perfused with a contrast agent. A corresponding method includes the step of providing a sequence of input images (for example, acquired with an ultrasound scanner); the input images offer a digital representation over time of the body-part. Each input image includes a plurality of input values (i.e., pixel or voxel values); each input value is indicative of a response to an interrogation signal (such as an echo signal for ultrasound waves) of a corresponding location of the body-part, which possibly includes the contrast agent. The method further includes the step of generating at least one filtered image from a plurality of selected ones of the input images (such as all of them or a subset thereof). Each filtered image includes a filtered value for each of a plurality of selected ones of the locations (for example, in a region of interest, or ROI). The filtered value of each selected location is indicative of the contrast agent that leaves the selected location after being substantially stationary at the selected location for a period of time, which is comprised between a first non-zero threshold and a second threshold higher than the first threshold (such as because the contrast agent detaches from the location after having been immobilized thereon, or because it was moving very slowly). The filtered value is obtained by reducing, where present, a contribution of the contrast agent that is substantially stationary at the selected location along the selected input images for a period of time equal to or shorter than the first threshold, and by reducing a contribution of the contrast agent that is substantially stationary at the selected location along the selected input images for a period of time equal to or longer than the second threshold.
摘要翻译： 提出了一种解决方案的实施例，用于对用造影剂灌注的身体部位进行成像。 相应的方法包括提供输入图像序列（例如，用超声波扫描器获取）的步骤; 输入图像随着身体部位的时间而提供数字表示。 每个输入图像包括多个输入值（即像素或体素值）; 每个输入值表示对可能包括造影剂的身体部位的对应位置的询问信号（例如超声波的回波信号）的响应。 该方法还包括从输入图像中的多个所选择的图像生成至少一个滤波图像（例如它们全部或其子集）的步骤。 每个滤波图像包括针对多个选择的位置（例如，在感兴趣区域或ROI中）中的每一个的滤波值。 每个所选择的位置的经滤波的值指示造影剂，其在被选择的位置基本上静止一段时间之后离开所选择的位置，该时间段包括在高于第一个的第一非零阈值和第二阈值之间 阈值（例如因为造影剂在被固定在其上之后从该位置分离，或者由于其移动非常缓慢）。 通过在现有的情况下，通过在等于或小于第一阈值的时间段内减少在所选择的位置处基本上静止在所选择的位置处的造影剂的贡献，并且通过减少 所述造影剂在所选择的输入图像的选定位置基本上静止等于或长于所述第二阈值的时间段。
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4.发明授权公开(公告)号：US08512249B2
公开(公告)日：2013-08-20
申请号：US12520839
申请日：2007-12-21
CPC分类号： G01S7/52041 , A61B8/481 , G01S7/52026 , G01S7/52038 , G01S7/52071 , G01S7/52074
摘要： An input image includes a plurality of input values (i.e., pixel or voxel values), each input value indicative of a response to an interrogation signal of a corresponding location of a body-part, which possibly includes a contrast agent. At least one filtered image is generated from a plurality of selected input images and includes a filtered value for each of a plurality of selected ones of the locations. Each filtered value is indicative of the contrast agent leaving the selected location and is obtained by reducing a contribution of the contrast agent that is substantially stationary at the selected location along the selected input images for a period of time equal to or shorter than a first threshold and by reducing a contribution of the contrast agent that is substantially stationary for a period of time equal to or longer than a second higher threshold.
摘要翻译： 输入图像包括多个输入值（即，像素或体元值），每个输入值指示对身体部位的相应位置的询问信号的响应，其可能包括造影剂。 从多个选择的输入图像生成至少一个滤波图像，并且包括针对多个选定位置中的每一个的滤波值。 每个滤波值表示离开所选择的位置的造影剂，并且是通过在所选择的输入图像的等于或小于第一阈值的时间段内减少基本上静止在选定位置的造影剂的贡献而获得的 并且通过减少在等于或长于第二较高阈值的时间段内基本静止的造影剂的贡献。
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公开(公告)号：US08496591B2
公开(公告)日：2013-07-30
申请号：US11794182
申请日：2005-12-21
申请人： Marcel Arditi , Peter Frinking , Nicolas Rognin
发明人： Marcel Arditi , Peter Frinking , Nicolas Rognin
摘要： A perfusion assessment system is proposed. The system includes means for providing an echo-power signal indicative of a perfusion of a contrast agent in a body-part under analysis, the contrast agent being administered as a bolus and undergoing a significant destruction during a passage of the contrast agent in the body-part, means for associating the echo-power signal to a model function including the product between a bolus function indicative of the passage of the contrast agent without said destruction and a reperfusion function indicative of a reperfusion of the contrast agent in the body part following the destruction corresponding to a substantially constant inflow of the contrast agent, and means for estimating at least one perfusion indicator from the bolus function and/or the reperfusion function.
摘要翻译： 提出了灌注评估系统。 该系统包括用于提供指示在分析的身体部位中的造影剂的灌注的回波功率信号的装置，所述造影剂作为推注施用并在造影剂在体内通过期间经历显着的破坏 - 将所述回波功率信号与模型功能相关联的模块功能，所述模型功能包括所述产品在指示所述造影剂通过之前没有所述破坏的推注功能和指示所述造影剂在体内部分再灌注的再灌注功能 对应于造影剂的基本上恒定的流入的破坏，以及用于从推注功能和/或再灌注功能估计至少一个灌注指示符的装置。
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公开(公告)号：US08929634B2
公开(公告)日：2015-01-06
申请号：US13393633
申请日：2010-09-01
申请人： Nicolas Rognin , Marcel Arditi , Laurent Mercier , Peter Frinking
发明人： Nicolas Rognin , Marcel Arditi , Laurent Mercier , Peter Frinking
CPC分类号： G06T7/0016 , G06T2207/10132 , G06T2207/30104
摘要： An embodiment for analyzing a body-part of a patient is proposed. A corresponding data-processing method includes the steps of providing a sequence of input images representing the body-part over an analysis period, each input image including a set of input values each one being indicative of a response to an interrogation signal of a corresponding location of the body-part at a corresponding acquisition instant included in the analysis period, associating an analysis function of time with each one of a set of selected locations, the analysis function modeling a trend of the input values of the selected location in the sequence of input images, and providing a reference function of time for the analysis functions; in an embodiment, the data-processing method further includes comparing the analysis function of each selected location with the reference function to determine a polarity trend representing a trend over the analysis period of a polarity of a divergence between the analysis function of the selected location and the reference function, and creating a parametric image including a parametric value for each selected location, the parametric value being indicative of the polarity trend of the selected location.
摘要翻译： 提出了一种用于分析患者身体部位的实施例。 相应的数据处理方法包括以下步骤：在分析周期内提供表示身体部分的输入图像序列，每个输入图像包括一组输入值，每个输入值指示对相应位置的询问信号的响应 在分析周期中包括的相应采集时刻的身体部分相关联，将时间分析功能与一组选定位置中的每一个相关联，分析功能模拟所选位置的输入值的趋势， 输入图像，并提供分析功能的时间参考功能; 在一个实施例中，数据处理方法还包括将每个所选择的位置的分析功能与参考功能进行比较，以确定代表所选位置的分析功能的极性的分析周期的趋势的极性趋势和 参考功能，以及创建包括每个选定位置的参数值的参数图像，参数值表示所选位置的极性趋势。
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7.发明授权公开(公告)号：US08021303B2
公开(公告)日：2011-09-20
申请号：US11823098
申请日：2007-06-25
申请人： Peter Frinking , Marcel Arditi , Nicolas Rognin
发明人： Peter Frinking , Marcel Arditi , Nicolas Rognin
摘要： A perfusion assessment system is proposed. The system includes means for providing an echo-power signal indicative of a reperfusion of a contrast agent in a body-part of a living subject following destruction of a significant portion of the contrast agent in the body-part, means for associating the echo-power signal to a perfusion function with an S-shape based on a plurality of elementary perfusion functions with said S-shape each one for a corresponding value of at least one perfusion parameter, the elementary perfusion functions being weighted according to a probability density distribution of the at least one perfusion parameter, wherein the S-shape includes an initial portion with substantially zero first derivatives, a final portion with substantially zero first derivatives, and a central portion between the initial portion and the final portion changing monotonically from a value of the initial portion to a value of the final portion, means for determining at least one shape indicator of the probability density distribution, and means for comparing the at least one shape indicator with at least one predetermined further shape indicator to identify morphological characteristics of the body-part according to a result of the comparison.
摘要翻译： 提出了灌注评估系统。 该系统包括用于在毁坏身体部位中的大部分造影剂之后提供指示生物体的身体部分中的造影剂再灌注的回波功率信号的装置， 根据具有所述S形的多个基本灌注函数的具有S形的灌注功能的功能信号，每个具有至少一个灌注参数的对应值，所述基本灌注函数根据概率密度分布进行加权 所述至少一个灌注参数，其中所述S形包括具有基本为零的一阶导数的初始部分，具有基本为零的一阶导数的最终部分，以及初始部分与最终部分之间的中心部分从 初始部分到最终部分的值，用于确定概率密度分布的至少一个形状指示符的装置 离子，以及用于将所述至少一个形状指示器与至少一个预定的另外的形状指示器进行比较的装置，以根据比较的结果来识别身体部位的形态特征。
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公开(公告)号：US20080139942A1
公开(公告)日：2008-06-12
申请号：US11885723
申请日：2006-03-03
申请人： Emmanuel Gaud , Peter Frinking , Nicolas Rognin , Sibylle Pochon , Nathalie Biolluz , Marcel Arditi
发明人： Emmanuel Gaud , Peter Frinking , Nicolas Rognin , Sibylle Pochon , Nathalie Biolluz , Marcel Arditi
IPC分类号： A61B8/00
CPC分类号： A61K49/223 , Y10S128/916
摘要： A medical imaging system is proposed. The system includes means for providing a plurality of echo signals indicative of a response of a body part to a plurality of ultrasound pulsed waves having different acoustic pressures, the body part including a tissue being perfused with a contrast agent, and means for discriminating in the echo signals a contribution of a first type of contrast agent from a contribution of a second type of contrast agent and/or of the tissue, at least one harmonic component of the contribution of the first type of contrast agent having an acoustic power changing according to a first dependency law on the acoustic pressure and the at least one harmonic component of the contribution of the second type of contrast agent and/or of the tissue having an acoustic power changing according to at least one second dependency law on the acoustic pressure, wherein the means for discriminating includes means for significantly reducing the at least one harmonic component of the contribution of the second type of contrast agent and/or of the tissue with respect to the at least one harmonic component of the contribution of the first type of contrast agent according to the corresponding dependency laws.
摘要翻译： 提出了一种医学成像系统。 该系统包括用于提供指示体部分对具有不同声压的多个超声脉冲波的响应的多个回波信号的装置，身体部分包括用造影剂灌注的组织，以及用于在 回波信号是来自第二类型的造影剂和/或组织的贡献的第一类型的造影剂的贡献，第一类型的造影剂的贡献的至少一个谐波分量具有根据 第二类造影剂和/或组织的声压和至少一个谐波分量的第一依赖规律具有根据至少一个第二依赖规律改变的声功率对声压，其中 用于鉴别的装置包括用于显着减少第二类型c的贡献的至少一个谐波分量的装置 根据相应的依赖规律相对于第一类型造影剂的贡献的至少一个谐波分量的组织和/或组织。
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公开(公告)号：US20120237098A1
公开(公告)日：2012-09-20
申请号：US13393633
申请日：2010-09-01
申请人： Nicolas Rognin , Marcel Arditi , Laurent Mercier , Peter Frinking
发明人： Nicolas Rognin , Marcel Arditi , Laurent Mercier , Peter Frinking
IPC分类号： G06K9/00
CPC分类号： G06T7/0016 , G06T2207/10132 , G06T2207/30104
摘要： An embodiment for analyzing a body-part of a patient is proposed. A corresponding data-processing method includes the steps of providing a sequence of input images representing the body-part over an analysis period, each input image including a set of input values each one being indicative of a response to an interrogation signal of a corresponding location of the body-part at a corresponding acquisition instant included in the analysis period, associating an analysis function of time with each one of a set of selected locations, the analysis function modeling a trend of the input values of the selected location in the sequence of input images, and providing a reference function of time for the analysis functions; in an embodiment, the data-processing method further includes comparing the analysis function of each selected location with the reference function to determine a polarity trend representing a trend over the analysis period of a polarity of a divergence between the analysis function of the selected location and the reference function, and creating a parametric image including a parametric value for each selected location, the parametric value being indicative of the polarity trend of the selected location.
摘要翻译： 提出了一种用于分析患者身体部位的实施例。 相应的数据处理方法包括以下步骤：在分析周期内提供表示身体部分的输入图像序列，每个输入图像包括一组输入值，每个输入值指示对相应位置的询问信号的响应 在分析周期中包括的相应采集时刻的身体部分相关联，将时间分析功能与一组选定位置中的每一个相关联，分析功能模拟所选位置的输入值的趋势， 输入图像，并提供分析功能的时间参考功能; 在一个实施例中，数据处理方法还包括将每个所选择的位置的分析功能与参考功能进行比较，以确定代表所选位置的分析功能的极性的分析周期的趋势的极性趋势和 参考功能，以及创建包括每个选定位置的参数值的参数图像，参数值表示所选位置的极性趋势。
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公开(公告)号：US20120082359A1
公开(公告)日：2012-04-05
申请号：US13377143
申请日：2010-06-08
IPC分类号： G06K9/00
CPC分类号： A61B8/5215 , A61B5/72 , A61B6/5211 , A61B8/06 , A61B8/481 , G06T5/009 , G06T5/40 , G06T2207/10132
摘要： An embodiment is proposed for analyzing a body-part. A corresponding embodiment of a data-processing method includes the steps of providing a parametric map including a plurality of parameter values each one characterizing a corresponding location of the body-part, and determining at least one statistical indicator of at least one distribution of a plurality of analysis parameter values corresponding to selected analysis locations, each statistical indicator being indicative of a condition of an analysis region of the body-part defined by the analysis locations. In an embodiment, the step of determining at least one statistical indicator includes, for each distribution of the analysis parameter values, determining a saturation value partitioning an ordered sequence of processing parameter values, corresponding to selected processing locations at least including the analysis locations, into a first subset and a second subset consisting of a number of the processing parameter values being determined according to a predefined auto-scaling percentage, generating an auto-scaled map including, for each processing location, an auto-scaled value being equal to the corresponding processing parameter value if included in the second subset, or the saturation value if the corresponding processing parameter value is included in the first subset, and determining the at least one statistical indicator from the auto-scaled values corresponding to the analysis locations.
摘要翻译： 提出了用于分析身体部位的实施例。 数据处理方法的相应实施例包括以下步骤：提供包括表征身体部位的对应位置的多个参数值的参数图，以及确定至少一个多个分布的分布的统计指标 对应于所选分析位置的分析参数值，每个统计指标指示由分析位置定义的身体部分的分析区域的状况。 在一个实施例中，确定至少一个统计指示符的步骤包括对于分析参数值的每个分布，确定将对应于至少包括分析位置的所选处理位置的处理参数值的有序序列划分为饱和值， 由根据预定义的自动缩放百分比确定的多个处理参数值组成的第一子集和第二子集，生成自动缩放图，包括对于每个处理位置，自动缩放值等于相应的 如果包括在第二子集中则处理参数值，或者如果相应的处理参数值包括在第一子集中则为饱和值，以及根据与分析位置对应的自动缩放值确定至少一个统计指标。
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